“…Transcripts emanating from centromeres have been observed in a myriad of systems, including budding yeast (Hedouin et al, 2022; Ohkuni and Kitagawa, 2011), human cells (Bury et al, 2020; Hoyt et al, 2022; McNulty et al, 2017; Quenet and Dalal, 2014), frog egg extracts (Blower, 2016; Grenfell et al, 2016), maize (Topp et al, 2004) and marsupials (Carone et al, 2013). Transcription at centromeres has been shown to be coupled to de novo centromere formation (Chen et al, 2015) and neocentromere formation in humans (Chueh et al, 2009; Murillo-Pineda et al, 2021; Naughton et al, 2022). In addition, centromeric transcription is critical for programmed histone exchange in S. pombe (Wu et al, 2022), for the stabilization of newly formed CENP-A nucleosomes in Drosophila cells (Bobkov et al, 2018), and for HAC formation (Cardinale et al, 2009).…”