Human CD1a molecule expressed on monocytes plays an accessory role in the superantigen-induced activation of T lymphocytes

Gregory, Stéphane; Zilber, Marie-Thérèse; Charron, Dominique; Gélin, Catherine

doi:10.1016/s0198-8859(99)00129-9

Cited by 13 publications

(11 citation statements)

References 39 publications

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“…This dissociated expression of the CD1 molecules on monocytes from SCA patients is clearly different from their expression on normal, activated monocytes that systemically coexpress CD1a, b, and c as previously described [13].…”

Section: Atypical Expression Pattern Of Cd1 Group I Isoforms On Monocmentioning

confidence: 42%

“…This particular CD1-positive phenotype of SCA monocytes is to compare with the classical phenotype encounter in the general population in which only 15% of the individuals express the CD1 molecules at the surface of their monocytes, expression that is related with a activated status of their lymphocytes [13].…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that the CD1 expression on monocytes of some healthy subjects is associated with an activation status of their lymphocytes [13]. Because the monocyte population of SCA patients is supposed to be activated, the monocyte CD1 phenotype from SCA patients has been explored.…”

Section: The Majority Of Sca Patients Express the Cd1 Molecules On Thmentioning

confidence: 99%

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Upregulation and atypical expression of the CD1 molecules on monocytes in sickle cell disease

et al. 2004

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Section: Atypical Expression Pattern Of Cd1 Group I Isoforms On Monocmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Section: The Majority Of Sca Patients Express the Cd1 Molecules On Thmentioning

confidence: 99%

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Upregulation and atypical expression of the CD1 molecules on monocytes in sickle cell disease

et al. 2004

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“…Resembling that of MHC class II molecules, CD1 molecules could participate in antigen presentation, especially presenting lipids or glycolipids from mycobacterium (33). Moreover, it is reported that the human CD1a molecule expressed on monocytes plays an accessory role in the superantigen-induced activation of T cells (34). GM-CSF can increase CD1 molecule expression on human monocytes (35).…”

Section: Cd4mentioning

confidence: 99%

Changes of CD14 and CD1a Expression in Response to IL-4 and Granulocyte-Macrophage Colony-Stimulating Factor Are Different in Cord Blood and Adult Blood Monocytes

Liu

Law

et al. 2001

Pediatr Res

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Neonates are relatively immature in their immune response; thus, to further clarify the differences of monocyte function and differentiation between neonates and adults, we investigated their CD14 ϩ CD4 ϩ and CD14 ϩ CD16 ϩ monocyte subpopulations, production of IL-1␤ and tumor necrosis factor-␣ induced by lipopolysaccharide, and their CD14 and CD1a phenotypic changes in response to IL-4 and granulocyte-macrophage colony-stimulating factor. Our results showed that 1) the expression of CD14 in cord blood monocytes was significantly lower than that in adult peripheral blood monocytes; 2) both the percentages of CD14 ϩ CD4 ϩ cells and CD14 ϩ CD16 ϩ cells among CD14 ϩ monocytes were also significantly lower in cord blood; 3) after stimulation by lipopolysaccharide for 72 h, production of both IL-1␤ and tumor necrosis factor-␣ was lower in cord blood than that in adult peripheral blood; and 4) in response to IL-4 or GM-CSF, the phenotype development of CD14 and CD1a in cord blood and adult peripheral blood was different. Downregulation of CD14 expression in response to IL-4 and GM-CSF was slower in cord blood monocytes than that in adult peripheral blood monocytes. After 9 d of culture in the presence of IL-4 and GM-CSF, the percentage of CD1a ϩ monocytes was significantly more increased in cord blood than that in adult peripheral blood. The reduced expression of CD14 and other mature phenotype markers such as CD16 and CD4 as well as the reduced IL-1␤ and tumor necrosis factor-␣ production may contribute to the impaired immune response of neonates. Slower down-regulation of CD14 by IL-4 and GM-CSF suggests that differential properties of cord blood monocytes in response to cellular stress signals take a longer time than those of adult peripheral blood monocytes. The monocyte plays an important role in host immunity. CD14, a glycoprotein of 55 kD present on most monocytes and tissue macrophages, is regarded as the most important myeloid differentiation antigen (1, 2). Functionally, CD14 acts as a receptor for the complex of LPS and LPS-binding protein (3), and mediates the response to LPS, such as the LPS-induced production of the cytokines TNF-␣, 4). The apoptosis of monocytes is associated with the down-regulation of CD14 expression (5), and CD14 is also a major receptor on phagocytes, which are involved in uptake of apoptotic cells (6). The expression of CD14 on PBMC is increased by LPS (7, 8) and decreased by IL-4 and GM-CSF (9 -11). In vitro, with CD14 down-regulation in response to IL-4 and GM-CSF, CD14ϩ monocytes can differentiate into cells displaying features of immature DC, which express CD1a (12).The heterogeneity of human PBMC in terms of size, function, and antigen expression has been reported (13,14). About 10% of the CD14 ϩ monocytes in peripheral blood express CD16, which is an Fc␥3 receptor (14, 15). The CD14 ϩ CD16 ϩ population represents more-mature monocytes and has higher antigen-presenting ability but lower phagocytic activity (16). Another antigen, CD4, is also expressed on a subpopulation of mon...

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“…Our data address that CD1a may be a novel biomarker for BM and that its expression may help to predict the prognosis of this pathology. CD1a is a surface glycoprotein of 43 -49 kDa that has been shown to be expressed by dendritic cells (DCs), cortical thymocytes and Langerhans cells of the skin (Dezutter-Dambuyant et al, 1990;Krenacs et al, 1993;Gregory et al, 2000). Moreover, the research of CD1a is commonly used to differentiate various cutaneous T-cell lymphomas from B-cell lymphomasand pseudolymphomas (Arai et al, 1999;Schmuth et al, 2001).…”

mentioning

confidence: 99%

CD1a expression by Barrett's metaplasia of gastric type may help to predict its evolution towards cancer

et al. 2005

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As emerging in the recent literature, CD1a has been regarded as a molecule whose expression may reflect tumour evolution. The aim of the present work was to investigate the expression of CD1a in a series of Barrett's metaplasia (BM), gastric type (GTBM), with and without follow-up, in order to analyse whether its expression may help to diagnose this disease and to address the outcome. Indeed, GTBM may be confused sometimes with islets of ectopic gastric mucosa and its evolution towards dysplasia (Dy) or carcinoma (Ca) could not be foreseen. We showed a significant higher expression of CD1a in GTBM than in both Dy and Ca; nevertheless, the number of positive GTBM was significantly lower in the group of cases that at follow-up underwent Dy or Ca. Our data address that CD1a may be a novel biomarker for BM and that its expression may help to predict the prognosis of this pathology. CD1a is a surface glycoprotein of 43 -49 kDa that has been shown to be expressed by dendritic cells (DCs), cortical thymocytes and Langerhans cells of the skin (Dezutter-Dambuyant et al, 1990;Krenacs et al, 1993;Gregory et al, 2000). Moreover, the research of CD1a is commonly used to differentiate various cutaneous T-cell lymphomas from B-cell lymphomasand pseudolymphomas (Arai et al, 1999;Schmuth et al, 2001).The antitumoral role of CD1a was recently proposed (Coventry and Morton, 2003a;Coventry and Heinzel, 2004;La Rocca et al, 2004). We also recently described that CD1a could be expressed in metaplastic epithelium of Barrett's oesophagus, both gastric and intestinal types, while normal gastric and colonic mucosa were negative to this marker (Cappello et al, 2003). In particular, we postulated that this marker may be useful in diagnosing Barrett's metaplasia (BM) and we hypothesised that its expression could predict a favourable outcome of this disease (Cappello, 2004).Indeed, BM may evolve towards dysplasia (Dy) or carcinoma (Ca) (Cameron and Carpenter, 1997; Malhi-Chowla et al, 2000;Moreto, 2003). Nevertheless, to date, we do not have any marker that could help to predict BM evolution.The aim of the present work was to detect CD1a expression in a large series of BM, Dy and Ca at the time of diagnosis and at follow-up. We would verify the diagnostic role of CD1a for BM and confirm our hypothesis concerning its prognostic role. MATERIALS AND METHODS Sample collectionWe selected retrospectively from our files, 222 cases as follows: 166 specimens were BM of gastric type (GTBM) that underwent follow up; moreover, we selected 37 specimens of Dy and 19 of Ca that did not undergo follow-up. Finally, as control group, we selected 10 specimens from normal gastric mucosa. Sample collection was performed according to ethical standards. In addition, we collected, from the 166 cases of GTBM, the specimens that underwent follow-up, commonly between 12 and 36 months from first diagnosis; in 134 cases, the diagnosis of BM was confirmed (FU-GTBM), while in 23 cases, GTBM evolved towards dysplasia (FU-Dy) and in nine cases towards carcinoma (FU-Ca). Imm...

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Human CD1a molecule expressed on monocytes plays an accessory role in the superantigen-induced activation of T lymphocytes

Cited by 13 publications

References 39 publications

Upregulation and atypical expression of the CD1 molecules on monocytes in sickle cell disease

Upregulation and atypical expression of the CD1 molecules on monocytes in sickle cell disease

Changes of CD14 and CD1a Expression in Response to IL-4 and Granulocyte-Macrophage Colony-Stimulating Factor Are Different in Cord Blood and Adult Blood Monocytes

CD1a expression by Barrett's metaplasia of gastric type may help to predict its evolution towards cancer

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