Human Cathelicidin CAP18/LL-37 Changes Mast Cell Function toward Innate Immunity

Yoshioka, Mino; Fukuishi, Nobuyuki; Kubo, Y.; Yamanobe, Hiroyuki; Ohsaki, Kanae; Kawasoe, Y.; Murata, M; Ishizumi, Aya; Nishii, Yumiko; Matsui, Nobuaki; Akagi, Masaaki

doi:10.1248/bpb.31.212

Cited by 59 publications

(60 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, we have recently shown that mast cells can be made to secrete non-Th2 cytokines selectively, by stimulation with bacterial cell wall products (94). Also, lipopolysaccharide (LPS) combined with LL-37 has been found to diminish Th2 cytokine production in mast cells (95). Collectively, we postulate that skewing the Th2 cytokine profile of mast cells towards Th1 may overall improve innate immune functions in allergic patients.…”

Section: Mast Cells -A Switch Board Of Innate Immunity and Allergic Rmentioning

confidence: 88%

Does allergy impair innate immunity? Leads and lessons from atopic dermatitis

Mrabet-Dahbi

Maurer

2010

Allergy

View full text Add to dashboard Cite

To cite this article: Mrabet‐Dahbi S, Maurer M. Does allergy impair innate immunity? Leads and lessons from atopic dermatitis. Allergy 2010; 65: 1351–1356.AbstractHost defence responses against invading pathogens are well‐balanced, inflammatory processes of the innate and adaptive immune system. Impaired development or abnormal function of either system can result in failure to control pathogens and to clear infections. Infections have been claimed to modulate the onset and course of allergic diseases. This so‐called hygiene hypothesis is still an active area of research. In contrast, the effects of allergies on infections and pathogen‐directed immune responses are less well understood. Here, we have reviewed the existing evidence that allergies result in impaired innate immunity and we discuss recent observations that may explain why and how innate immunity is dysfunctional in allergic patients. With a focus on atopic dermatitis as a model of allergic disease, we speculate that one of the key features of allergic conditions, namely Th2 polarization, leads to several independent inhibitory effects on host defence and consequently to a higher risk of infections in allergic patients. A better understanding of impaired host defence and its mechanisms in allergic subjects will help to improve the management of these diseases.

show abstract

Section: Mast Cells -A Switch Board Of Innate Immunity and Allergic Rmentioning

confidence: 88%

Does allergy impair innate immunity? Leads and lessons from atopic dermatitis

Mrabet-Dahbi

Maurer

2010

Allergy

View full text Add to dashboard Cite

show abstract

“…(3,9). Although mast cells express transcript for FPR2, the effects of LL-37 do not appear to be mediated via this receptor (17,40). It is noteworthy that mast cells are the only known cells outside the dorsal ganglia that express MrgX2 (28).…”

Section: Ll-37 Induces Degranulation In Human Mast Cells Via Pertussimentioning

confidence: 99%

Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells

Subramanian

Gupta

Guo

et al. 2011

Journal of Biological Chemistry

196

241

View full text Add to dashboard Cite

Background: Antimicrobial peptide LL-37 activates leukocytes, mast cells, and endothelial cells. Results: LL-37 causes chemotaxis, degranulation, and chemokine production in human mast cells expressing MrgX2, but it does not induce receptor desensitization. Conclusion: MrgX2 is a novel receptor for LL-37 in human mast cells, and this receptor is resistant to regulation. Significance: This study has important implications for innate immunity and inflammation.

show abstract

“…LL-37 is an amphipathic ␣-helical peptide, composed of 37 amino acids (14). In addition to its antimicrobial activity, LL-37 has been shown to bind to lipopolysaccharide (24) and to possess immunomodulatory functions such as chemotactic signaling, induction of dendritic cell differentiation, and modulation of mast cell function (2,6,7,42). Additionally, LL-37 and its mouse homolog have been shown to promote wound healing (18,30) and angiogenesis (23).…”

mentioning

confidence: 99%