Human Case of<i>Bartonella alsatica</i>Lymphadenitis

Angelakis, Emmanouil; Lépidi, Hubert; Canel, Atbir; Rispal, P; Perraudeau, Françoise; Barre, Isabelle; Rolain, Jean‐Marc; Raoult, Didier

doi:10.3201/eid1412.080757

Cited by 46 publications

(31 citation statements)

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“…For example, B. henselae is commonly found in domestic and wild felids worldwide, including in Africa (Pretorius et al 2004b, Chomel et al 2006, Chomel and Kasten 2010, and B. alsatica is associated with rabbits (Angelakis et al 2008). Other animal hosts of Bartonella species include dogs, coyotes, foxes, cattle, deer, elk, and multiple species of rodents (Breitschwerdt and Kordick 2000, Minnick and Anderson 2006, Chomel and Kasten 2010.…”

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confidence: 99%

Identification ofBartonellaein the Soft Tick SpeciesOrnithodoros sonraiin Senegal

Mediannikov

Diatta

Kasongo

et al. 2014

Vector-Borne and Zoonotic Diseases

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Ticks, belonging to the soft ticks species Ornithodorus sonrai, have been collected from six sites in Senegal and were tested for the presence of Bartonella spp. Initial screening by PCR revealed the presence of these bacteria in ticks from two villages, Soulkhou Thissé (5/8, 62.5%) and Maka Gouye (1/24, 4.2%). Three bacterial strains were isolated from live ticks, and the genetic characterization of these strains suggests that they belong to two previously unknown species. The pathogenicity of these two new species of Bartonella is not yet known. The new isolates described here are the first strains of Bartonella spp. from soft ticks and the first isolates from any arthropod species in Africa.

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confidence: 99%

Identification ofBartonellaein the Soft Tick SpeciesOrnithodoros sonraiin Senegal

Mediannikov

Diatta

Kasongo

et al. 2014

Vector-Borne and Zoonotic Diseases

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“…By qPCR, we found 340 lymph nodes (53%) infected with B. henselae. One lymph node was ITS positive and pap31 negative and was identified as B. alsatica (19). M. tuberculosis was detected in 42 (6%) patients, M. avium in 27 (4%) patients, Mycobacterium genavense in 2 (0.3%) patients, and Mycobacterium bolletti in 2 (0.3%) patients.…”

Section: Resultsmentioning

confidence: 99%

Bacterial Lymphadenitis at a Major Referral Hospital in France from 2008 to 2012

et al. 2014

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Lymph node enlargement is a common medical problem, and in a large number of patients, the causes of lymphadenopathy remain undiagnosed. We report a thorough microbiological analysis of 1,688 lymph node biopsy specimens collected in our bartonellosis reference center. We studied lymph node biopsy samples from patients with suspected regional infectious lymph node enlargement from January 2008 to December 2012. To evaluate a useful strategy for the diagnosis of infectious lymphadenitis, specimens were cultured and subjected to molecular assays. Histologic analysis was done when possible. A total of 642 (38%) biopsy specimens were infected with a bacterial agent, and quantitative PCR (qPCR) was significantly better than 16S rRNA gene PCR (rrs) for the detection of Bartonella henselae (P ‫؍‬ 0.05), Mycobacterium tuberculosis (P ‫؍‬ 0.05), and Mycobacterium avium (P ‫؍‬ 0.007). Molecular assays were significantly better than bacterial cultures for the diagnosis of Francisella tularensis (P ‫؍‬ 0.017) but were less effective for detecting M. tuberculosis (P ‫؍‬ 0.004) and M. avium (P ‫؍‬ 0.001). Histologic analysis was done for 412 lymph nodes, and 20% of these were compatible with an infectious lymphadenitis, whereas a neoplasm was found in 29% of these lymph nodes. M. tuberculosis was detected significantly more in female than in male patients (P ‫؍‬ 0.01), and patients with cat scratch disease (CSD) were younger than patients with M. tuberculosis, Tropheryma whipplei, and F. tularensis. Negative rrs PCR does not exclude the diagnosis of infectious lymphadenitis. Histologic analysis of lymph node biopsy specimens is critical, as a diagnosis of infectious lymphadenitis does not preclude other concurrent diseases.

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“…Bartonella alsatica is a human pathogen that was formerly isolated from the blood of European rabbit in Alsace Department, France (Heller et al 1999), and identified as a causative agent of endocarditis and lymphadenitis in humans (Raoult et al 2006, Angelakis et al 2008, Jeanclaude et al 2009). European rabbit (Oryctolagus cuniculus) has been indicated as the natural host of this Bartonella species, but the vector has not yet been determined (Vayssier-Taussat et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection of Bartonella alsatica in European Wild Rabbits (Oryctolagus cuniculus) in Andalusia (Spain)

Márquez

2010

Vector-Borne and Zoonotic Diseases

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A sample of 279 European wild rabbits, Oryctolagus cuniculus (141 males, 138 females), captured alive in Andalusia (Spain) and belonging to the two haplotype classes previously described for this species (230 and 49 corresponding with haplotypes A and B, respectively), were tested for the presence of Bartonella alsatica DNA. Two species-specific nested polymerase chain reaction assays targeting for 16S-23S rRNA intergenic spacer region and RNA polymerase β subunit genes have been developed. Forty-eight (17.20%) rabbits were infected with B. alsatica. Two-way contingency table analyses and the calculation of Cramer's V statistic showed no differences in infection rate, considering haplotype lineage or sex. The risk of infection of human population, especially for hunters in close contact with this demonstrated human pathogen, should be considered.

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Human Case ofBartonella alsaticaLymphadenitis

Cited by 46 publications

References 10 publications

Identification ofBartonellaein the Soft Tick SpeciesOrnithodoros sonraiin Senegal

Identification ofBartonellaein the Soft Tick SpeciesOrnithodoros sonraiin Senegal

Bacterial Lymphadenitis at a Major Referral Hospital in France from 2008 to 2012

Molecular Detection of Bartonella alsatica in European Wild Rabbits (Oryctolagus cuniculus) in Andalusia (Spain)

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