Human bronchial-pulmonary proteomics in coronavirus disease 2019 (COVID-19) pandemic: applications and implications

Tan, Heng Wee; Xu, Yan‐Ming; Lau, Andy T. Y.

doi:10.1080/14789450.2021.2010549

Cited by 3 publications

(3 citation statements)

References 148 publications

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“…The paired analyses empowered the study's ability to comprehensively reveal potential mechanisms and regulatory networks that respond to SARS‐CoV‐2 infection. More recently, novel single‐cell multi‐omics have been used to investigate to better understand SARS‐CoV‐2‐induced immune responses 222–226 . For instance, scRNA‐seq, CITE‐seq (cellular indexing of transcriptomes and epitopes sequencing), TCR‐seq (T cell receptor sequencing) and BCR‐seq (B cell receptor sequencing) have been utilized to illustrate the dynamic responses of the innate and adaptive immune systems to SARS‐CoV‐2 227 .…”

Section: Challenges and Future Considerationsmentioning

confidence: 99%

“…More recently, novel single‐cell multi‐omics have been used to investigate to better understand SARS‐CoV‐2‐induced immune responses. 222 , 223 , 224 , 225 , 226 For instance, scRNA‐seq, CITE‐seq (cellular indexing of transcriptomes and epitopes sequencing), TCR‐seq (T cell receptor sequencing) and BCR‐seq (B cell receptor sequencing) have been utilized to illustrate the dynamic responses of the innate and adaptive immune systems to SARS‐CoV‐2. 227 The high‐throughput immune profiling revealed progressive COVID‐19 was associated with dyssynchrony of the innate and adaptive immune responses.…”

Section: Challenges and Future Considerationsmentioning

confidence: 99%

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Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

Yuan

Zou

et al. 2023

Cell Proliferation

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Coronavirus disease 2019 (COVID‐19), a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has posed a catastrophic threat to human health worldwide. Human stem cell‐derived organoids serve as a promising platform for exploring SARS‐CoV‐2 infection. Several review articles have summarized the application of human organoids in COVID‐19, but the research status and development trend of this field have seldom been systematically and comprehensively studied. In this review, we use bibliometric analysis method to identify the characteristics of organoid‐based COVID‐19 research. First, an annual trend of publications and citations, the most contributing countries or regions and organizations, co‐citation analysis of references and sources and research hotspots are determined. Next, systematical summaries of organoid applications in investigating the pathology of SARS‐CoV‐2 infection, vaccine development and drug discovery, are provided. Lastly, the current challenges and future considerations of this field are discussed. The present study will provide an objective angle to identify the current trend and give novel insights for directing the future development of human organoid applications in SARS‐CoV‐2 infection.

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Section: Challenges and Future Considerationsmentioning

confidence: 99%

Section: Challenges and Future Considerationsmentioning

confidence: 99%

Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

Yuan

Zou

et al. 2023

Cell Proliferation

View full text Add to dashboard Cite

show abstract

“…Additionally, severe COVID-19associated hyperinflammatory syndromes have been reported that they originate from a host innate immune response (37). Studies of transcriptome, proteomic, and epigenomics have revealed a wide range of functional impairments, including marked neutrophil hyperactivation symptoms in severe COVID-19 (38)(39)(40)(41). Collectively, COVID-19 caused by SARS-CoV-2 is associated with a failure of innate and adaptive immune system regulation due to changes in other immune cells associated with a decrease in adaptive T cells.…”

Section: Dysregulated Immune Response In Covid-19mentioning

confidence: 99%

New Discovery of Myeloid-Derived Suppressor Cell’s Tale on Viral Infection and COVID-19

et al. 2022

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Myeloid-derived suppressor cells (MDSCs) are generated under biological stress such as cancer, inflammatory tissue damage, and viral infection. In recent years, with occurrence of global infectious diseases, new discovery on MDSCs functions has been significantly expanded during viral infection and COVID-19. For a successful viral infection, pathogens viruses develop immune evasion strategies to avoid immune recognition. Numerous viruses induce the differentiation and expansion of MDSCs in order to suppress host immune responses including natural killer cells, antigen presenting cells, and T-cells. Moreover, MDSCs play an important role in regulation of immunopathogenesis by balancing viral infection and tissue damage. In this review article, we describe the overview of immunomodulation and genetic regulation of MDSCs during viral infection in the animal model and human studies. In addition, we include up-to-date review of role of MDSCs in SARS-CoV-2 infection and COVID-19. Finally, we discuss potential therapeutics targeting MDSCs.

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Bioinformatics and molecular biology tools for diagnosis, prevention, treatment and prognosis of COVID-19

Meira,

Zetum,

Casotti

et al. 2024

Heliyon

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Human bronchial-pulmonary proteomics in coronavirus disease 2019 (COVID-19) pandemic: applications and implications

Cited by 3 publications

References 148 publications

Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

New Discovery of Myeloid-Derived Suppressor Cell’s Tale on Viral Infection and COVID-19

Bioinformatics and molecular biology tools for diagnosis, prevention, treatment and prognosis of COVID-19

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