Human breastmilk-derived
            <i>Bifidobacterium longum</i>
            subsp.
            <i>infantis</i>
            CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway

Ding, Mengfan; Li, Bowen; Chen, Haiqin; Liang, Dong; Ross, R. Paul; Stanton, Catherine; Zhao, Jianxin; Chen, Wei; Yang, Bo

doi:10.1080/19490976.2023.2290344

Cited by 3 publications

(5 citation statements)

References 55 publications

(62 reference statements)

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“…infantis in vitro (data not shown). B6MNI affected the content of tryptophan metabolites through a mouse model [ 44 ] , which may be the reason for its different effects compared to the other seven strains B. longum subsp. infantis .…”

Section: Discussionmentioning

confidence: 99%

“…Supplementing specific Bifidobacterium or Lactobacillus in the early stages of life to prevent the occurrence and development of allergic diseases in infants and young children can contribute to their healthy development. For example, Lactobacillus rhamnosus HN001 supplementation can reduce the incidence of eczema in infants by 50% [43] . Additionally, taking HN001 from birth to 2 years old can prolong the preventive or relieving effect on eczema to 4 years old [43] .…”

Section: Discussionmentioning

confidence: 99%

“…For example, Lactobacillus rhamnosus HN001 supplementation can reduce the incidence of eczema in infants by 50% [43] . Additionally, taking HN001 from birth to 2 years old can prolong the preventive or relieving effect on eczema to 4 years old [43] . This study found that 8 strains of B. longum subsp.…”

Section: Discussionmentioning

confidence: 99%

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Bifidobacterium longum subsp. infantis regulates Th1/Th2 balance through the JAK-STAT pathway in growing mice

Ding,

Li,

Chen

et al. 2024

Microbiome Res Rep

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Objectives: Bifidobacterium longum subsp. infantis is a dominant bacterium in infant gut, which plays a critical role in maintaining the health and development of infants. This study investigated the abilities of eight different strains of B. longum subsp. infantis to regulate the T helper (Th)1/Th2 balance. Methods: Eight B . longum subsp. infantis strains, including I2MI (FJSWXI2MIM1), I4MI [FJSWXI4MI (CCFM1270)], I4MNI (FJSWXI4MNIM1), I5TI (FJSWXI5TIM1), I6TI (FJSWXI6TIM1), I8TI [FJSWXI8TI (CCFM1271)], I10TI [FJSWXI10TI (CCFM1272)], and B6MNI [BJSWXB6MNIM1 (CCFM1269)], were gavaged to BALB/C pups in both female (n = 8) and male (n = 8) mice starting from 1 to 3 weeks old (1 × 109 CFU/day/mice). Selected immune cells were assessed by immunofluorescence and flow cytometry. Cytokines and immunoglobulins were determined by ELISA. Bacterial and bifidobacterial communities were determined by 16S rRNA gene sequencing and bifidobacterial groEL sequencing. Results: B . longum subsp. infantis I4MI and I8TI were shown to increase the ration of colonic IgG2a/IgE in male mice (P < 0.05). B6MNI was demonstrated to significantly increase the levels of colonic IFN-γ and IgG2a, as well as the ratio of IgG2a/IgE in female mice (P < 0.05). It was also shown to significantly increase the ratio of colonic IgG2a/IgE (P < 0.05) and reduce the level of colonic IL-4 in male mice (P < 0.05). Furthermore, B6MNI was demonstrated to regulate colonic JAK/STAT pathway in both male and female mice. I4MI, I5TI, and B6MNI were shown to increase the relative abundance of Bifidobacterium and B. longum subsp. infantis in both male and female mice, whereas I8TI was only shown to increase the relative abundance of Bifidobacterium and B. longum subsp. infantis in male mice (P < 0.05). Conclusion: These results indicated supplementation with B. longum subsp. infantis in early infancy may regulate the Th1/Th2 immune balance, which may prevent the development of related diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bifidobacterium longum subsp. infantis regulates Th1/Th2 balance through the JAK-STAT pathway in growing mice

Ding,

Li,

Chen

et al. 2024

Microbiome Res Rep

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“…B. infantis is an important colonizer of the neonatal gut, with multiple physiological functions including modulating the immune system, influencing the overall nutrition status of infants and most recently, promoting bone formation and brain injury recovery [57][58][59][60].…”

Section: The Role Of B Infantis In Early-life Developmentmentioning

confidence: 99%

“…Emerging preclinical studies suggest that B. infantis are important for the skeletal system through the gut-bone axis and the neural system through the gut-brain axis [58,59]. Supplementation of B. infantis positively impacted the overall bone length and the activity of bone-remodeling cells by stimulating the PI3K/AKT pathway through the GH/IGF-1 axis in growing mice.…”

Section: The Role Of B Infantis In Early-life Developmentmentioning

confidence: 99%

Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of Bifidobacterium longum subsp. infantis M-63 on Infant Health

Wong,

Huang,

Ning

et al. 2024

Microorganisms

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A healthy gut microbiome is crucial for the immune system and overall development of infants. Bifidobacterium has been known to be a predominant species in the infant gut; however, an emerging concern is the apparent loss of this genus, in particular, Bifidobacterium longum subsp. infantis (B. infantis) in the gut microbiome of infants in industrialized nations, underscoring the importance of restoring this beneficial bacterium. With the growing understanding of the gut microbiome, probiotics, especially infant-type human-residential bifidobacteria (HRB) strains like B. infantis, are gaining prominence for their unique ability to utilize HMOs and positively influence infant health. This article delves into the physiology of a probiotic strain, B. infantis M-63, its symbiotic relationship with HMOs, and its potential in improving gastrointestinal and allergic conditions in infants and children. Moreover, this article critically assesses the role of HMOs and the emerging trend of supplementing infant formulas with the prebiotic HMOs, which serve as fuel for beneficial gut bacteria, thereby emulating the protective effects of breastfeeding. The review highlights the potential of combining B. infantis M-63 with HMOs as a feasible strategy to improve health outcomes in infants and children, acknowledging the complexities and requirements for further research in this area.

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Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies

Pan,

Yin,

et al. 2024

Food Frontiers

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Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence of bone‐related diseases, significantly compromising individuals’ quality of life. The gut microbiota actively participates in the regulation of bone metabolism, and perturbations in the gut microbiota can exacerbate bone diseases by compromising gut barrier integrity. Determining the microbial taxa involved in bone loss could offer valuable insights into the development of alternative therapies and nutritional interventions for disease management. Therefore, based on metagenomic and 16S ribosomal RNA data, this study analyzed the gut microbiota structure of 488 individuals with different bone masses (NC, normal; ON, osteopenia; OP, osteoporosis) to identify significant associations between the gut microbiota and bone loss. The results showed that at the genus and species levels, the microbiota diversity of the ON population increased, whereas that of the OP population decreased. Bacteroides were significantly enriched in the OP population, whereas the beneficial bacteria Bifidobacterium, Akkermansia, and lactobacilli decreased. Subsequent analyses revealed no significant variation in different bone populations in terms of Bifidobacterium levels, whereas lactobacilli exhibited diverse responses across distinct bone populations. The administration of lactobacilli effectively enhanced lumbar spine bone mineral density and modulated the gut microbiota structure in a population with unhealthy bone mass. This study contributes to the validation of the association between the gut microbiota and bone mass, enhances our understanding of the potential impact of probiotics (lactobacilli) on bone mass, and establishes a robust scientific basis for the application of probiotics in the regulation of bone mass.

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Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway

Cited by 3 publications

References 55 publications

Bifidobacterium longum subsp. infantis regulates Th1/Th2 balance through the JAK-STAT pathway in growing mice

Bifidobacterium longum subsp. infantis regulates Th1/Th2 balance through the JAK-STAT pathway in growing mice

Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of Bifidobacterium longum subsp. infantis M-63 on Infant Health

Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies

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