Human breast milk sugars and polyols over the first 10 puerperium days

Jóźwik, Maciej; Jóźwik, Marcin; Teng, Cecilia; Battaglia, Frederick C.

doi:10.1002/ajhb.22352

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…The other significant carbohydrates found in HM are oligosaccharides, the concentrations of most of which, not all, have been shown to decline during the course of lactation although HM concentrations of 3-FL either increased throughout lactation or remained at relatively constant concentrations starting at 1 month onwards ( 199 , 200 ). The colostrum to milk transition was also associated with significant changes in concentrations of free sugars and polyols (increased in concentrations of lactose and glucose, decreased in concentrations of Myo-inositol and glycerol) over the first 3 days after birth and thereafter reaching a steady state ( 201 ).…”

Section: Resultsmentioning

confidence: 99%

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

et al. 2020

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Human milk (HM) is dynamic and shows a high inter- and intra-individual variability. To characterize HM with precision, it is necessary to understand the factors that modulate its composition. The objective of this narrative review is to summarize the maternal, infant and methodological factors that affect HM composition. We searched SCOPUS and PubMed databases for articles related to factors that are known to or could potentially influence HM composition and volume across lactation periods. Our comprehensive review encompasses various maternal-, infant-related, and methodological factors that modulate aspects of HM composition including macro- and micronutrients, vitamins and minerals, as well as volume. The most profound changes were observed in HM lipids and lipophiles. Evidence exists for many of the infant-related factors known to affect the nutritive and non-nutritive components of HM (e.g., birth weight, gestational age, infant age/stage of lactation). In contrast, less is known with respect to maternal factors; where there is either limited research or conflicting evidence (e.g., maternal lifestyle, obstetric history, medical conditions), except for the mother's diet, for which there is a relatively well-established understanding. Equally, although many of the methodological factors (e.g., HM sampling, handling and analytics) are known to impact HM composition, few studies have investigated this as a primary outcome, making it an important area of future research in HM. Here we propose a systematic capture of numerous maternal- and infant-related characteristics to facilitate associative comparisons of HM data within and across studies. Additionally, it would be prudent to standardize the methodological aspects known to affect HM composition in analytics, not only for HM lipids and lipophiles, but also for those nutrients whose variability is yet less well-understood. Defining the factors determining HM composition with accuracy will open perspectives for maternal intervention to optimize milk composition for specific needs of infants.

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Section: Resultsmentioning

confidence: 99%

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

et al. 2020

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“…The transition from colostrum to mature breast milk during early puerperium is associated with significant concentration changes of numerous compounds, including concentrations of free sugars and polyols. It has been repeatedly observed that, after the first days of a term postpartum, the concentrations of lactose and glucose increase significantly (Neville et al, 1984;van Beusekom et al, 1993, Coppa et al, 1993Cavalli et al, 2006;Gabrielli et al, 2011;Jóźwik et al, 2013).…”

Section: Discussionmentioning

confidence: 98%

Bacteriological, Biochemical, and Immunological Properties of Colostrum and Mature Milk From Mothers of Extremely Preterm Infants

Moles¹,

Manzano²,

Fernández³

et al. 2015

J. pediatr. gastroenterol. nutr.

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“…While galactosemia morbidity and mortality is amenable to management by galactose-restricted diet, the chronic morbidity in classic galactosemia in not amenable to management by diet. The earlier the institution of galactose-restricted diet the better the prognosis, as children with galactosemia are challenged in their early days by life-threatening amounts of galactose, given that breast milk is rich in lactose that is a disaccharide composed of galactose and glucose [16] .…”

Section: Discussionmentioning

confidence: 99%

Pilot study of classic galactosemia: Neurodevelopmental impact and other complications urge neonatal screening in Egypt

Kotb

Mansour

Basanti

et al. 2018

Journal of Advanced Research

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Human breast milk sugars and polyols over the first 10 puerperium days

Abstract: The colostrum-to-milk transition is associated with significant changes in concentrations of free sugars and polyols, changes which are completed by the fourth postpartum day. Parity influences the concentrations of some compounds in the breast milk.

Cited by 11 publications

References 39 publications

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

Bacteriological, Biochemical, and Immunological Properties of Colostrum and Mature Milk From Mothers of Extremely Preterm Infants

Pilot study of classic galactosemia: Neurodevelopmental impact and other complications urge neonatal screening in Egypt

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