Human Breast Lesions: Characterization with Contrast-enhanced in Vivo Proton MR Spectroscopy—Initial Results

Yeung, D.; Cheung, H. T. Andrew; Tse, Gary

doi:10.1148/radiology.220.1.r01jl0240

Cited by 175 publications

(169 citation statements)

References 25 publications

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“…Compared to 15 N choline, 11 C choline has a half-life of B20 min and the dose injected in rats is B0.2 ml (0.3-0.4 GBq). 22 However, recent studies have shown that 15 N in deuterated choline 40 has a lifetime of only 3 times less than that of 11 C-choline.…”

Section: This Journal Is C the Owner Societies 2010mentioning

confidence: 99%

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Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Cudalbu

Comment

Kurdzesau

et al. 2010

Phys. Chem. Chem. Phys.

120

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The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo 13 C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized 15 N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 AE 16 s) and in vivo (126 AE 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized 15 N labeled choline in live animals.

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Section: This Journal Is C the Owner Societies 2010mentioning

confidence: 99%

“…[9][10][11][12][13] The increase of tCho in tumors has become a potentially important biomarker in cancer diagnosis. [14][15][16] Recent results have shown a significant decrease of tCho concentration in breast cancers responding to chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Cudalbu

Comment

Kurdzesau

et al. 2010

Phys. Chem. Chem. Phys.

120

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“…Initially, a simple dichotomous approach based on the presence or absence of the choline peak was shown in some reports (5,6). Furthermore, choline quantification has been proposed using either an internal or an external reference (9,10).…”

Section: Discussionmentioning

confidence: 99%

¹H‐magnetic resonance spectroscopy of the breast at 3.0‐T: Comparison of results obtained before and after administration of gadolinium‐based contrast agent

Kawai

Naganawa

Satake

et al. 2011

Magnetic Resonance Imaging

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Purpose: To assess the effects of gadolinium-based contrast agent (GBCA) on 1 H-magnetic resonance spectroscopy (MRS) of the breast at 3.0-T. Materials and Methods:Patients (n ¼ 98) with breast cancer (98 lesions) underwent MRS (point-resolved spectroscopy sequence [PRESS]; TR/TE, 2000/100 msec; voxel size, 15 Â 15 Â 15 mm) before the administration of GBCA. In 52 of those patients, MRS was also performed after the administration of GBCA. The voxel-of-interest (VOI) was placed by referring to the noncontrastenhanced MRI (diffusion-weighted images combined with fat-suppressed T2-weighted images). We reviewed and graded the appropriateness of VOI location compared to the correlating enhancement lesions. Integral values of the choline peak at a frequency of 3.2 ppm on MRS were compared before and after the administration of GBCA. Results:The VOI was placed correctly in 64 lesions (65%), although the VOI was placed outside the targeted lesion in 34 lesions (35%). The integral value of the choline peak on MRS decreased significantly after the administration of GBCA (P < 0.001).Conclusion: Accumulation of GBCA in breast cancer could affect the choline peak on MRS. MRS of breast cancer at 3.0-T can be recommended to be acquired before contrast-enhanced study; however, some problems remain in VOI placement with reference to the noncontrast-enhanced study.

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“…Breast cancer can be distinguished from benign lesions and from normal breast tissues by a dramatic increase (from undetectable to clearly visible at 1.5 T) of the choline (Cho) signal in 1 H MRS [18][19][20][21][22][23][24][25][26][27][28][29]. Cho, consisting of free, phospho-, glycerophospho-and phospholipidcholine, is a classic in vivo biomarker for cellular proliferation.…”

Section: Introductionmentioning

confidence: 99%

A high spatial resolution 1H magnetic resonance spectroscopic imaging technique for breast cancer with a short echo time

Kou

et al. 2008

Magnetic Resonance Imaging

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The high sensitivity but low specificity of breast MRI has prompted exploration of breast 1 H MRS for breast cancer detection. However, several obstacles still prevent the routine application of in vivo breast 1 H MRS, including poor spatial resolution, long acquisition time associated with conventional multi-voxel MRS imaging (MRSI) techniques, and the difficulty of "extra" lipid suppression in a magnetic field with relatively poor achievable homogeneity compared to the brain. Using a combination of a recently developed echo-filter (EF) suppression technique and an elliptical sampling scheme, we demonstrate the feasibility of overcoming these difficulties. It is robust (the suppression technique is insensitive to magnetic field inhomogeneity), fast (acquisition time of about 12 min) and offers high spatial resolution (up to 0.6 cm 3 per voxel at 1.5 T with a TE of only 60 ms). This approach should be even better at 3 T with higher resolution and/or shorter TE.

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Human Breast Lesions: Characterization with Contrast-enhanced in Vivo Proton MR Spectroscopy—Initial Results

Cited by 175 publications

References 25 publications

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

¹H‐magnetic resonance spectroscopy of the breast at 3.0‐T: Comparison of results obtained before and after administration of gadolinium‐based contrast agent

A high spatial resolution 1H magnetic resonance spectroscopic imaging technique for breast cancer with a short echo time

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Human Breast Lesions: Characterization with Contrast-enhanced in Vivo Proton MR Spectroscopy—Initial Results

Cited by 175 publications

References 25 publications

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

1H‐magnetic resonance spectroscopy of the breast at 3.0‐T: Comparison of results obtained before and after administration of gadolinium‐based contrast agent

A high spatial resolution 1H magnetic resonance spectroscopic imaging technique for breast cancer with a short echo time

Contact Info

Product

Resources

About

¹H‐magnetic resonance spectroscopy of the breast at 3.0‐T: Comparison of results obtained before and after administration of gadolinium‐based contrast agent