2020
DOI: 10.3389/fnins.2020.00404
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Human Breast Cancer Cells Demonstrate Electrical Excitability

Abstract: Breast cancer is one of the most prevalent types of cancers worldwide and yet, its pathophysiology is poorly understood. Single-cell electrophysiological studies have provided evidence that membrane depolarization is implicated in the proliferation and metastasis of breast cancer. However, metastatic breast cancer cells are highly dynamic microscopic systems with complexities beyond a single-cell level. There is an urgent need for electrophysiological studies and technologies capable of decoding the intercellu… Show more

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Cited by 40 publications
(49 citation statements)
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“…as expected due to the low concentration of ions; values are reasonable as the dH2O resistance is rated at 18.2 MΩ.cm and there is a 1 mm gap between electrodes. PBS impedance is in the order of kΩ, also reasonable for this concentration (Ribeiro et al, 2020). The results presented…”
Section: Nano Bpe Systemssupporting
confidence: 73%
“…as expected due to the low concentration of ions; values are reasonable as the dH2O resistance is rated at 18.2 MΩ.cm and there is a 1 mm gap between electrodes. PBS impedance is in the order of kΩ, also reasonable for this concentration (Ribeiro et al, 2020). The results presented…”
Section: Nano Bpe Systemssupporting
confidence: 73%
“…For instance, multi‐electrode arrays detected a higher electrical activity of metastatic versus non‐metastatic breast cancer cells associated with a higher activity of VGSCs. [ 102 ] Fluorescence reporters have also been suggested for bioelectricity measurements due to their inherent advantage of high resolution, simplistic in vivo analysis, and ability to track bioelectric gradients over long periods even with ongoing cellular activities. [ 103 ] A vibrating probe made up of an insulated, sharpened metal wire with a small platinum‐black tip has been used to non‐invasively measure the bioelectric current (μA cm −2 range) near cells and tissues in physiological media.…”
Section: Strategies To Hijack Endogenous Bioelectricity Of Cancer Cellsmentioning
confidence: 99%
“…Also very relevant are the community effects associated with cell electrical communication, leading to both short and long range influence and patterns 42 , and their importance in cancer, as the link between the cells’ bioelectric state and invasiveness 49 or the role signaling by calcium permeable channels play in tumor progress 50 . The manipulation of the tissue bioelectric state, profiting from the long range impact and propagation of the polarization state, can be an effective and efficient approach for cancer prevention and therapy.…”
Section: Discussionmentioning
confidence: 99%