Human brain activity associated with painful mechanical stimulation to muscle and bone

Maeda, Lynn; Ono, Mayu; Koyama, Tetsuo; Oshiro, Yasuo; Sumitani, Masahiko; Mashimo, Takashi; Shibata, Masahiko

doi:10.1007/s00540-011-1173-9

Cited by 18 publications

(19 citation statements)

References 22 publications

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“…The pgACC showed increased activation specifically for FM patients, in agreement with previous findings showing that chronic pain patients do not deactivate pgACC/medial PFC and/or surrounding regions of the ‘default mode’ network as strongly as controls do (and sometimes show activation)[2; 5; 6; 12; 27; 63; 72]. Conversely, the PCC/precuneus may activate in response to pressure-evoked pain in both healthy[4; 16; 43; 65] and patient populations[27; 48; 59; 65]. The value of ‘default mode’ network regions as predictors of pain may therefore vary across pain modalities and pain patient groups.…”

Section: Discussionsupporting

confidence: 89%

Towards a neurophysiological signature for fibromyalgia

López‐Solà

Woo

Pujol

et al. 2016

Pain

205

194

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Fibromyalgia (FM) patients show characteristically enhanced unpleasantness to painful and non-painful sensations accompanied by altered neural responses. The diagnostic potential of such neural alterations, including their sensitivity and specificity to FM (vs. healthy controls) is unknown. We identify a brain signature that characterizes FM central pathophysiology at the neural systems level. We included 37 FM patients and 35 matched healthy controls, and analyzed fMRI responses to (i) painful pressure and (ii) non-painful multisensory (visual-auditory-tactile) stimulation. We used machine-learning techniques to identify a brain-based FM signature. When exposed to the same painful stimuli, FM patients showed greater Neurologic Pain Signature (NPS, Wager 2013) responses. In addition, a new pain-related classifier (‘FM-pain’) revealed augmented responses in sensory integration (insula/operculum) and self-referential (e.g., medial prefrontal) regions in FM, and reduced responses in the lateral frontal cortex. A ‘Multisensory’ classifier trained on non-painful sensory stimulation revealed augmented responses in insula/operculum, posterior cingulate, and medial prefrontal regions, and reduced responses in primary/secondary sensory cortices, basal ganglia and cerebellum. Combined activity in the NPS, FM-pain, and Multisensory patterns classified patients vs. controls with 92% sensitivity and 94% specificity in out-of-sample individuals. Enhanced NPS responses partly mediated mechanical hypersensitivity, and correlated with depression and disability(puncorrected<0.05); FM-pain and Multisensory responses correlated with clinical pain(puncorrected<0.05). The study provides initial characterization of individual FM-patients based on pathophysiological, symptom-related brain features. If replicated, these brain features may constitute objective neural targets for therapeutic interventions. The results establish a framework for assessing therapeutic mechanisms and predicting treatment response at the individual level.

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Section: Discussionsupporting

confidence: 89%

Towards a neurophysiological signature for fibromyalgia

López‐Solà

Woo

Pujol

et al. 2016

Pain

205

194

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“…Neuroimaging studies using functional MRI in healthy volunteers or in patients with pain syndrome under various nociceptive stimulus provided image evidences for the involvement of the CPu in pain perception, and the CPu might be an important subcortical structure participating in nociceptive modulation [5,23]. Arginine vasopressin was found to induce ACh release from the rat CPu to participate in pain modulation [24].…”

Section: Discussionmentioning

confidence: 98%

“…The neurons in the CPu can recognize noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus, and may contribute toward the behavioral response to minimize bodily harm [4]. Functional MRI studies have shown changes in the blood oxygen level-dependent CPu signal in participants following noxious stimulation of muscle and bone [5]. Furthermore, CPu stimulation has been shown to increase the pain threshold and strengthen the analgesic effect of electroacupuncture [6].…”

Section: Introductionmentioning

confidence: 97%

Acetylcholine plays an antinociceptive role by modulating pain-induced discharges of pain-related neurons in the caudate putamen of rats

Yang²,

Ma³

et al. 2014

NeuroReport

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The caudate putamen (CPu) has been suggested to be involved in nociceptive modulation. Some neurotransmitters, including acetylcholine (ACh), participate in pain modulation in the central nervous system. However, the active mechanism of ACh on the pain-related neurons in the CPu remains unclear. This study aimed to investigate the effects of the cholinergic agonists ACh and pilocarpine and the muscarinic ACh receptor antagonist atropine on the pain-induced response of pain-related neurons in the CPu of Wistar rats. Trains of electrical impulses applied to the sciatic nerve of rat were used as the noxious stimulus. The electrical activities of pain-excited neurons (PENs) or pain-inhibited neurons (PINs) in the CPu were recorded by a glass microelectrode. Our results showed that an intra-CPu injection of 4 μg/2 μl ACh or pilocarpine decreased and increased the pain-induced discharge frequency in the PENs and PINs, respectively. Intra-CPu administration of 1 μg/2 μl atropine produced the opposite effect on these neurons. These findings indicate that ACh may play an analgesic role by affecting the electric activities of PENs and PINs, and the muscarinic pathway may be involved in the modulation of pain perception in the CPu.

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“…Two previous fMRI studies conducted in Japan by Uematsu et al [3] and Maeda et al [4] on normal healthy subjects help to provide data on where increased activation levels in the brain are expected in response to a painful stimulus. Both experiments used a hand held digital algometer (Pressure Algometer NPA-1, Shinko, Japan) with a 10mm diameter hemispherical probe.…”

Section: Introductionmentioning

confidence: 99%

An MR safe algometer to study phantom and residual limb pain

Hui¹,

Hughes²,

Wu³

et al. 2012

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Researchers are interested in understanding phantom limb pain (PLP) and residual limb pain (RLP) in amputees and the neural mechanisms leading to it. fMRI can provide information on the intensity and the location of activated centers in the brain that control PLP and RLP. MR safe algometers are important to this work. This paper described the new pneumatically actuated algometer and the evaluation methods for MR safety. Our results indicate that the custom device is an improved MR safe algometer capable of autonomously producing reproducible pressure profiles.

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Human brain activity associated with painful mechanical stimulation to muscle and bone

Cited by 18 publications

References 22 publications

Towards a neurophysiological signature for fibromyalgia

Towards a neurophysiological signature for fibromyalgia

Acetylcholine plays an antinociceptive role by modulating pain-induced discharges of pain-related neurons in the caudate putamen of rats

An MR safe algometer to study phantom and residual limb pain

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