Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism

Attané, Camille; Estève, David; Chaoui, Karima; Iacovoni, Jason S.; Corre, Jill; Moutahir, M; Valet, Philippe; Burlet‐Schiltz, Odile; Reina, Nicolas; Müller, Cathérine

doi:10.1016/j.celrep.2019.12.089

Cited by 82 publications

(108 citation statements)

References 58 publications

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“…Thus, the effect of fasting on BM adipocytes needs to be dissected in detail. For example, a recent paper by Attané et al described that BM adipocytes display distinct metabolic characteristics with an absence of lipolytic activity and a shift toward a cholesterol-oriented metabolism [15]. How this impacts on the interaction between BM adipocytes and leukemia needs to be investigated.…”

Section: Open Questions and Future Directions Of Scientific Researchmentioning

confidence: 99%

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Zinngrebe¹,

Debatin²,

Fischer‐Posovszky³

2020

Leukemia

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The bone marrow is home to well-balanced normal hematopoiesis, but also the stage of leukemia’s crime. Marrow adipose tissue (MAT) is a unique and versatile component of the bone marrow niche. While the importance of MAT for bone health has long been recognized, its complex role in hematopoiesis has only recently gained attention. In this review article we summarize recent conceptual advances in the field of MAT research and how these developments impact our understanding of MAT regulation of hematopoiesis. Elucidating routes of interaction and regulation between MAT and cells of the hematopoietic system are essential to pinpoint vulnerable processes resulting in malignant transformation. The concept of white adipose tissue contributing to cancer development and progression on the cellular, metabolic, and systemic level is generally accepted. The role of MAT in malignant hematopoiesis, however, is controversial. MAT is very sensitive to changes in the patient’s metabolic status hampering a clear definition of its role in different clinical situations. Here, we discuss future directions for leukemia research in the context of metabolism-induced modifications of MAT and other adipose tissues and how this might impact on leukemia cell survival, proliferation, and antileukemic therapy.

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Section: Open Questions and Future Directions Of Scientific Researchmentioning

confidence: 99%

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Zinngrebe¹,

Debatin²,

Fischer‐Posovszky³

2020

Leukemia

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“…While large, insulin-resistant adipocytes, which are more sensitive to lipolysis, characterize VAT with a rich vasculature and innervation, containing higher levels of macrophages, T cells, and natural killer cells, SAT is characterized by small insulin-sensitive adipocytes, lower vascularity, innervation, and immune cell infiltration (Ibrahim, 2010). Compared with the other AT depots, BMAT displays distinctive features as a more heterogeneous depot containing adipocytes of divergent phenotypes (Hardouin et al, 2016) that display a specific cholesterol-orientated lipid metabolism devoid of lipolytic activity (Attané et al, 2020).…”

Section: Adipose Tissue Niche Constituentsmentioning

confidence: 99%

“…On the one hand, marrow adipocyte develops from bone marrow mesenchymal stromal cells (BM-MSCs), where their precursors share the features of osteoblasts, expressing leptin receptors (Zhou et al, 2014), osterix (Mizoguchi et al, 2014), and nestin, as described in animal models (Horowitz et al, 2017). On the other hand, human BM-MSCs in vitro did not recapitulate marrow adipogenesis or the functional properties of BMAT, such as reduced lipolysis (compared with SAT) and a cholesterol-based metabolism (Scheller et al, 2016;Attané et al, 2020). The phenotype of the BMAT progenitors is still unknown, while a recent study based on large-scale scRNAsequencing data indicated the existence of nonproliferative marrow APs in mice, which are responsible for BMAT formation (Zhong et al, 2020).…”

Section: Adipose Tissue Niche Constituentsmentioning

confidence: 99%

Adipogenesis in Different Body Depots and Tumor Development

Trivanović¹,

Petrinović

Djordjević

et al. 2020

Front. Cell Dev. Biol.

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Adipose tissue (AT) forms depots at different anatomical locations throughout the body, being in subcutaneous and visceral regions, as well as the bone marrow. These ATs differ in the adipocyte functional profile, their insulin sensitivity, adipokines' production, lipolysis, and response to pathologic conditions. Despite the recent advances in lineage tracing, which have demonstrated that individual adipose depots are composed of adipocytes derived from distinct progenitor populations, the cellular and molecular dissection of the adipose clonogenic stem cell niche is still a great challenge. Additional complexity in AT regulation is associated with tumor-induced changes that affect adipocyte phenotype. As an integrative unit of cell differentiation, AT microenvironment regulates various phenotype outcomes of differentiating adipogenic lineages, which consequently may contribute to the neoplastic phenotype manifestations. Particularly interesting is the capacity of AT to impose and support the aberrant potency of stem cells that accompanies tumor development. In this review, we summarize the current findings on the communication between adipocytes and their progenitors with tumor cells, pointing out to the coexistence of healthy and neoplastic stem cell niches developed during tumor evolution. We also discuss tumor-induced adaptations in mature adipocytes and the involvement of alternative differentiation programs.

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“…Of interest, a recent study characterized a unique population of human bone marrow adipocytes[ 30 ], discovering a profound downregulation of MGL expression which was shown to underlie the metabolic differences in the phenotype/lipid metabolism, also justifying bone marrow adipocytes’ resistance to caloric restrictions[ 30 ]. Further studies showed that when Mgl -/- animals were challenged with high fat diet feeding, great amounts of 2-AG were detected in the brain, although affecting neither food consumption nor body weight, therefore evidencing cannabinoid receptors desensitizing effects[ 23 ].…”

Section: Pre-clinical Studies On Monoacylglycerol Lipase Deletion/inhmentioning

confidence: 99%

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

Tardelli¹

2020

WJG

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Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, which eventually progress to cirrhosis and hepatocellular carcinoma. Monoacylglycerol lipase is the last enzymatic step in the hydrolysis of triglycerides, generating glycerol and fatty acids (FAs), which are signaling precursors in physiology and disease. Notably, monoacylglycerol lipase (MGL) also hydrolyzes 2-arachidonoylglycerol, which is a potent ligand within the endocannabinoid system, into arachidonic acid - a precursor for prostaglandin synthesis; thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from FA metabolism to inflammation, pain and appetite. MGL inhibition has been shown protective in limiting several liver diseases as FAs may drive hepatocyte injury, fibrogenesis and de- activate immune cells, however the complexity of MGL network system still needs further and deeper understanding. The present review will focus on MGL function and FA partitioning in the horizons of liver disease.

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Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism

Cited by 82 publications

References 58 publications

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Adipogenesis in Different Body Depots and Tumor Development

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

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