Human Bocavirus in Children Hospitalized for Acute Gastroenteritis: A Case‐Control Study

Cheng, Wei-xia; Yu, Jin; Duan, Zhaojun; Xu, Ziqian; Qi, Hongmei; Zhang, Qing; Yu, Jie-mei; Zhu, Lin; Jin, Miao; Liu, Na; Cui, Shu-xian; Li, Huiying; Fang, Zhao-Yin

doi:10.1086/589244

Cited by 83 publications

(72 citation statements)

References 34 publications

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“…Human bocaviruses were the most commonly detected viruses and were found in all but two of the analyzed states (Wisconsin and Louisiana) ( Table 1). HBoV1 has a very broad geographical distribution when respiratory samples are analyzed but is less commonly detected in stool samples (3,6,13,27,29,30,50,53,54,59). In this study, HBoV1 was detected in only one city in Florida, while HBoV2 and HBoV3 were detected in sewage samples from all bocavirus-positive cities (Fig.…”

Section: Discussionmentioning

confidence: 60%

“…HBoV was first identified in 2005 in respiratory tract samples from Sweden (4) and was later found, although less frequently, in stool samples from children with gastroenteritis in South and North America, Europe, Africa, Asia, and Australia (6,13,27,30,54,59). A related species, human bocavirus 2 (HBoV2), was recently identified in approximately 5% of stool samples from South Asian children, both healthy and with non-polio-associated AFP, and in about 0.4% of clinical stool samples from United Kingdom residents (two children and one adult) (31).…”

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confidence: 99%

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Frequent Detection of Highly Diverse Variants of Cardiovirus , Cosavirus , Bocavirus , and Circovirus in Sewage Samples Collected in the United States

et al. 2009

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Untreated sewage samples from 12 cities in the United States were screened for the presence of recently characterized RNA and DNA viruses found at high prevalence in the stool specimens of South Asian children. Genetic variants of human cosaviruses and cardioviruses in the Picornaviridae family and of DNA circoviruses and human bocaviruses were detected, expanding the known genetic diversity and geographic range of these newly identified viruses. All four virus groups were detected in sewage samples of less than a milliliter from multiple U.S. cities. PCR screening of particle-protected viral nucleic acid in sewage samples could therefore rapidly establish the presence and determine the diversity of four newly described enteric viruses in large urban populations. More frequent and deeper sampling of viral nucleic acids in sewage samples could be used to monitor changes in the prevalence and genetic composition of these and other novel enteric viruses.

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Section: Discussionmentioning

confidence: 60%

mentioning

confidence: 99%

Frequent Detection of Highly Diverse Variants of Cardiovirus , Cosavirus , Bocavirus , and Circovirus in Sewage Samples Collected in the United States

et al. 2009

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“…Coinfection with other intestinal pathogens was found in 21 to 58% of these cases. Recently, the results of large uncontrolled and controlled studies by Yu et al (20) and Cheng et al (5) did not support a causative role for HBoV as a gastroenteritis agent in children hospitalized with diarrhea, despite frequent fecal HBoV detection. Thus, HBoV is frequently detected in feces but its association with gastrointestinal infection is less clear.…”

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confidence: 98%

Human Bocavirus in an Immunocompromised Child Presenting with Severe Diarrhea

et al. 2009

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Human bocavirus (HBoV) is frequently detected in young children with respiratory symptoms. However, the prevalence and pathogenicity of HBoV in immunocompromised patients are largely unknown. This report describes a case of life-threatening hypovolemic shock due to diarrhea associated with disseminated HBoV infection in an immunocompromised child. CASE REPORTA 9-year-old boy with erythropoietic protoporphyria was admitted to the University Medical Center Groningen, Groningen, The Netherlands. He had undergone orthotopic liver transplantation and allogeneic hematopoietic stem cell transplantation 9 and 4 months prior to admission, respectively. He presented with fever, nausea, vomiting, and diarrhea of 1-day duration. Clinical examination showed a moderately sick boy with a temperature of 39.5°C, tachycardia (pulse rate, 150 beats per min), normal blood pressure, and normal hydration status. Pulmonary examination detected a minor cough and minor rales upon auscultation. Examination of the abdomen revealed hyperperistalsis, no tenderness, and palpable edges of the liver and spleen. Laboratory results showed an elevated C-reactive protein level (51 mg liter Ϫ1 ; normal, Յ10 mg liter Ϫ1 ) and erythrocyte sedimentation rate (106 mm h Ϫ1 ; normal, Յ25 mm h Ϫ1 ) and a normal leukocyte count. The patient had severe therapy-induced lymphopenia (20 CD3 ϩ T cells l Ϫ1 ; normal range, 700 to 4,200 l Ϫ1 ). Liver chemistry test results were stable but elevated due to biliary complications after liver transplantation. Bacterial blood cultures and fecal cultures for Campylobacter, Salmonella, and Shigella spp. and Escherichia coli O157 were negative. PCR analyses of feces for noroviruses (genogroups I and II), adenovirus, parechovirus, enterovirus, and cytomegalovirus and antigen detection assays of feces for rotavirus and astrovirus were all negative. In contrast, feces results were positive for human bocavirus (HBoV) by PCR (threshold cycle [C T ] value in week 49 of 2007, 17) (Fig.

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“…The main biological features of viruses associated with acute gastroenteritis in humans are shown in Table 1. Other viruses, such as Aichi virus, parechovirus, and bocavirus have been recently described in patients with diarrhea, but their association with AGE has not yet been established clearly [7,[11][12][13][14][15]. Although rotavirus is reported to be the most common pathogen in children worldwide, the role of other enteric viruses is relatively less understood [1,16].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of viral gastroenteritis: limits and potential of currently available procedures

Sidoti

Rittá

Costa

et al. 2015

J Infect Dev Ctries

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The diagnostic approaches to viral gastroenteritis have evolved substantially over the past decades because of the advances in detection methods, the emergence of new pathogens, and the increase in diarrhea hospitalizations attributed to viruses, especially in young children in non-industrialized countries. Overall, these factors have lead to a relevant improvement of types and operating characteristics of diagnostic methods (including sensitivity and specificity), as well as turnaround time. In this review, clinical and laboratory approaches to the diagnosis of viruses causing gastroenteritis are presented; in particular, specimen collection and detection methods are reviewed and discussed, taking into account performance and limitations.

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Human Bocavirus in Children Hospitalized for Acute Gastroenteritis: A Case‐Control Study

Abstract: A single genetic lineage of HBoV was revealed in persons in China. Despite its high prevalence in stool samples, our study does not support a causative role of HBoV in gastroenteritis.

Cited by 83 publications

References 34 publications

Frequent Detection of Highly Diverse Variants of Cardiovirus , Cosavirus , Bocavirus , and Circovirus in Sewage Samples Collected in the United States

Frequent Detection of Highly Diverse Variants of Cardiovirus , Cosavirus , Bocavirus , and Circovirus in Sewage Samples Collected in the United States

Human Bocavirus in an Immunocompromised Child Presenting with Severe Diarrhea

Diagnosis of viral gastroenteritis: limits and potential of currently available procedures

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