Human Bocavirus DNA in Paranasal Sinus Mucosa

Falcone, Valeria; Ridder, Gerd Jürgen; Panning, Marcus; Bierbaum, Sibylle; Neumann‐Haefelin, Dieter; Huzly, Daniela

doi:10.3201/eid1708.101944

Cited by 17 publications

(17 citation statements)

References 10 publications

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“…HBoV1 might, however, have a more narrow tissue tropism for its persistence; in one study, high HBoV1 detection rates (up to 32%) were encountered among tonsillectomy patients suggesting that lymphatic tissue might be a persistence site . Of note, a rather high detection rate (18%) of HBoV1 has been reported also in tissue samples of chronic sinusitis .…”

Section: Persistencementioning

confidence: 97%

Human bocavirus—the first 5 years

Jartti

Hedman

Jartti

et al. 2011

Reviews in Medical Virology

240

278

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Four species of human bocavirus (HBoV) have been recently discovered and classified in the Bocavirus genus (family Parvoviridae, subfamily Parvovirinae). Although detected both in respiratory and stool samples worldwide, HBoV1 is predominantly a respiratory pathogen, whereas HBoV2, HBoV3, and HBoV4 have been found mainly in stool. A variety of signs and symptoms have been described in patients with HBoV infection including rhinitis, pharyngitis, cough, dyspnea, wheezing, pneumonia, acute otitis media, fever, nausea, vomiting, and diarrhea. Many of these potential manifestations have not been systematically explored, and they have been questioned because of high HBoV co-infection rates in symptomatic subjects and high HBoV detection rates in asymptomatic subjects. However, evidence is mounting to show that HBoV1 is an important cause of lower respiratory tract illness. The best currently available diagnostic approaches are quantitative PCR and serology. This concise review summarizes the current clinical knowledge on HBoV species.

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Section: Persistencementioning

confidence: 97%

Human bocavirus—the first 5 years

Jartti

Hedman

Jartti

et al. 2011

Reviews in Medical Virology

240

278

View full text Add to dashboard Cite

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“…Other authors evaluated the presence of picornaviruses in nasal washing and turbinate mucosa from 39 patients affected by CRSwNP and 27 healthy people and found a 21% rhinovirus positivity in patients, while no virus was found in controls [22]. A more recent study investigated CARVs in paranasal sinus mucosa and polyps by multiplex PCR and found a 18% positivity to bocavirus and <2% positivity to rhinovirus in 102 tissue samples from 88 patients [23]. In the present study, the lack of CARVs detection in any specimen (but the cytological sample) seems to argue against a potential involvement of these viruses in this clinical context.…”

Section: Discussionmentioning

confidence: 99%

Detection of Herpesviruses 1-6 and Community-Acquired Respiratory Viruses in Patients with Chronic Rhinosinusitis with Nasal Polyposis

Costa¹,

Garzaro

Boggio

et al. 2014

Intervirology

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Objective: To evaluate the prevalence of human herpesviruses (HHV) 1-6 and community-acquired respiratory viruses (CARVs) in specimens from patients with nasal polyposis undergoing functional endoscopic sinus surgery (FESS) and investigate the potential clinical role. Methods: Viral occurrence was evaluated by molecular methods in polyp, turbinate mucosa, and pre- and postoperative scraping specimens from 35 consecutive patients at different time points in relation to FESS. Results: Overall, 21 patients (60%) were positive to at least one virus in at least one specimen; in particular, 12.1% of all specimens for HHV-6 (3/35 polyps, 11/31 turbinates, 1 presurgical scraping) and 10.5% for Epstein-Barr virus (EBV) (8/35 polyps, 3/31 turbinates, 1/29 pre- and 1/29 postsurgical scraping), followed by CMV and HSV-1 (both 1.6%; 1/35 polyps, 1/29 postsurgical scraping and 2/35 polyps, respectively). EBV positivity tended to be higher in polyps, as well as HHV-6 in adjacent healthy turbinate mucosa, although no significant association was found. Only one preoperative cytological specimen was positive to parainfluenza virus-1. Conclusion: No association between the development of nasal polyps, herpesviruses and CARVs seems to exist. However, the higher EBV frequency in polyps could suggest a causative role or persistence in the inflammatory lymphoid tissue.

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“…69,70 A study showed that it can be often identified in the sinus tissue specimens of adult patients with chronic sinusitis. 71…”

Section: Human Bocavirusmentioning

confidence: 99%