Human Bocavirus Detection in Nasopharyngeal Aspirates of Children Without Clinical Symptoms of Respiratory Infection

García-García, Maria Luz; Calvo, Cristina; Pozo, Francisco; Pérez-Breña, Pilar; Quevedo, Sergio; Bracamonte, Teresa; Casas, Inmaculada

doi:10.1097/inf.0b013e3181626d2a

Cited by 73 publications

(71 citation statements)

References 9 publications

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“…In addition, a second group of asymptomatic children of different ages but in coincident epidemic seasons was studied. The group of children with HRV was substantially smaller than the group of children with respiratory disease ( 15 ). …”

Section: Discussionmentioning

confidence: 76%

Role of Rhinovirus C in Apparently Life-Threatening Events in Infants, Spain

Calvo¹,

García²,

Pozo³

et al. 2009

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 76%

Role of Rhinovirus C in Apparently Life-Threatening Events in Infants, Spain

Calvo¹,

García²,

Pozo³

et al. 2009

Emerg. Infect. Dis.

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“…It was subsequently detected in serum (16)(17), fecal (18)(19) and urine samples (20). HBoV detection was significantly higher in patients with symptoms of respiratory tract infections or gastroenteritis than in asymptomatic individuals (14,16,(21)(22)(23). Findings of a recent study suggest that acute infection of HBoV causes systemic infection, induces immune responses and is often associated with coinfection (24).…”

Section: Introductionmentioning

confidence: 94%

High prevelance of human parvovirus infection in patients with malignant tumors

Dong

Jiang

et al. 2012

Oncology Letters

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Abstract.It is well known that the immunity of patients with malignant tumors decreases significantly. An increased parvovirus B19 (B19) infection rate has been observed in immunocompromised hosts. However, only a small amount of literature regarding the risk of human parvovirus infection in patients with malignant tumors is available. To evaluate the correlation of human parvovirus infection with malignant tumors, 288 serum samples from patients with malignant tumors were screened for B19 DNA by nested-PCR. The serum samples, 156 of which were from known clinicopathological cancer patients, were subjected to analysis of the seropositive rate of human bocavirus (HBoV), hepatitis B virus (HBV) and transfusion transmitted virus (TTV) by PCR. A total of 800 normal population sera and 941 aspirate samples from children with respiratory tract infections were used as controls for the detection of B19 and HBoV, respectively. Pairwise comparison between cancerous serum and control samples, and the correlation between parvovirus infection and clinicopathological variables, including gender and cancer type, were evaluated using the χ2 test, Fisher's exact test or the t-test. P<0.05 was considered to indicate a statistically significant difference. The overall prevalence of B19 DNA in cancer patients was 50.69% (146/288), which was significantly higher than that of the healthy controls with 4.5% (36/800) (χ2 test, P<0.0001). Similar results were obtained for HBoV with a 39.74% (62/156) prevalence in cancer patients. However, the infection prevalence of HBV and TTV in the cancer patients was 5.13 (8/156) and 6.41% (10/156), respectively (P<0.0001), which was much less than that of B19 and HBoV. These results revealed that a high risk of B19 and HBoV infection occurred in cancer patients, and a potential correlation exists between parvovirus infection and occurrence of malignant tumors.

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“…Desde su descubrimiento se han descrito cuatro grupos o "clades" (HBoV 1-4), asociados con infecciones respiratorias y gastrointestinales en países de todo el mundo [2][3][4] . Diversos estudios han reportado la presencia de HBoV en el tracto respiratorio, utilizando técnicas de biología molecular, con frecuencias que varían entre 1,5 y 19% entre niños con IRA [5][6][7][8][9][10][11][12][13][14][15] , y entre 0 y 43% en muestras respiratorias de pacientes asintomáticos 7,14,[16][17][18][19][20] . Por otra parte, se ha descrito co-infección con otros agentes virales, principalmente virus respiratorio sincicial (VRS) y adenovirus, entre 9 y 90% 13,16 .…”

Section: Introductionunclassified

“…Un gran número de pacientes se presentan con cargas virales bajas 14,23,29,30 , y ha sido demostrada su excreción hasta por 6 meses 20,21 , lo cual sugiere persistencia del virus por períodos prolongados. Además, varios estudios han reportado alta prevalencia de HBoV en pacientes asintomáticos, entre 5 y 43% [18][19][20] , altas tasas de co-infección con otros virus, y su presencia en deposiciones [31][32][33][34] , suero 9,14 y orina 13 , lo cual sugiere una infección sistémica.…”

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Bocavirus humano en Chile: características clínicas y epidemiológicas en niños con infecciones respiratorias

et al. 2011

Rev. chil. infectol.

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Background: Human bocavirus (HBoV) is a newly discovered parvovirus found in children with acute respiratory tract infections (ARTI). Objectives: To describe the epidemiological and clinical profi le of children < 5 years old consulting for ARTI, comparing cases of HBoV monoinfection and coinfection with other known respiratory viruses. Furthermore, we aimed to estimate the prevalence of viral shedding in asymptomatic children and perform phylogenetic analysis. Patients and Methods: We investigated the presence of HBoV in nasopharyngeal secretions from children consulting for ARTI and among asymptomatic controls, between 2007 and 2008, by polymerase chain reaction. Results: HBoV was detected in 79 (21.8%) of 362 nasopharyngeal swabs obtained from children with ARTI. In 60/79 (76%), coinfection with other respiratory viruses was confi rmed. Most common symptoms were cough, fever and rhinorrhea. Children infected only with HBoV showed signifi cantly lower frequencies of respiratory distress, oxygen requirements and hospital admission than those with coinfection. HBoV was detected in 6/16 (37.5%) samples from asymptomatic children. The phylogenetic analysis of viruses from Chilean patients revealed that circulating HBoV was closely related to original strains. Conclusions: HBoV was found either in symptomatic and asymptomatic children. The severity of the disease was greater when HBoV was associated to other respiratory viruses.

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Human Bocavirus Detection in Nasopharyngeal Aspirates of Children Without Clinical Symptoms of Respiratory Infection

Cited by 73 publications

References 9 publications

Role of Rhinovirus C in Apparently Life-Threatening Events in Infants, Spain

Role of Rhinovirus C in Apparently Life-Threatening Events in Infants, Spain

High prevelance of human parvovirus infection in patients with malignant tumors

Bocavirus humano en Chile: características clínicas y epidemiológicas en niños con infecciones respiratorias

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