Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

Fry, Alicia M.; Lu, Xiaoyan; Chittaganpitch, Malinee; Peret, Teresa C. T.; Fischer, Julie E.; Dowell, Scott F.; Anderson, Larry J.; Erdman, Dean D.; Olsen, Sonja J.

doi:10.1086/512163

Cited by 268 publications

(343 citation statements)

References 22 publications

(34 reference statements)

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“…However, the present study indicated that Ct values are informative only for some agents. HBoV has in other studies been co-detected with other viruses in up to 80% of samples [Allander et al, 2007;Fry et al, 2007]. In the present study, 60% of HBoV findings were co-infections.…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses

Tiveljung-Lindell

Rotzén-Östlund

Gupta

et al. 2008

Journal of Medical Virology

106

107

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Acute respiratory tract infections are caused by a large number of viruses. Diagnostic methods have until recently been available only for a limited number of these viruses. With the objective to achieve sensitive assays for all respiratory viruses, a rational workflow in the laboratory, and a short turn-around time, a real-time PCR diagnostic platform for daily rapid detection of 15 respiratory viruses was developed. The system was evaluated on 585 stored nasopharyngeal aspirates from hospitalized children. Previous analysis by immunofluorescence and virus isolation identified viruses in 37% of the samples while the new PCR diagnostic panel detected 57% virus positive samples. The new platform was introduced in the laboratory in October 2007 and has then fully replaced the standard immunofluorescence assay for rapid detection of viruses and virus isolation.

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Section: Discussionsupporting

confidence: 62%

“…There is also gathering evidence for a pathogenic role of human bocavirus (HBoV), mainly when the virus is present at a high viral load [Allander et al, 2007;Fry et al, 2007;Kantola et al, 2008].…”

Section: Introductionmentioning

confidence: 99%

Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses

Tiveljung-Lindell

Rotzén-Östlund

Gupta

et al. 2008

Journal of Medical Virology

106

107

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show abstract

“…En nuestro estudio, los diagnósticos de egreso más frecuentes fueron neumonía, bronquitis y bronquiolitis, coincidiendo con resultados de un estudio en Córdoba, donde encontraron que 79% de los pacientes positivos para HBoV presentaban IRA baja como diagnóstico 23 . Lo mismo ocurre en trabajos publicados de China 7,11 , Brasil 10 y Tailandia, que hallaron HBoV en aspirados nasofaríngeos de pacientes con neumonía 31 . Los episodios de sibilancia también fueron un diagnostico frecuente en nuestro estudio (15,6%), hecho ya reportado, al igual que la asociación de HBoV con los episodios de exacerbación del asma 13,32 .…”

Section: Artículo Originalunclassified

Detección de bocavirus humano en la población infantil de Tucumán y Santa Fe, Argentina

Vera-Garate

Rudi

Gómez

et al. 2016

Rev. chil. infectol.

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“…HBoV1 shows high infection rates globally, and has been associated with acute respiratory disease in infants and young children (Kesebir et al, 2006;Allander et al, 2007;Fry et al, 2007;Jartti et al, 2012;Paloniemi et al, 2014;Martin et al, 2015). Three additional types of human bocavirus, HBoV2, -3 and -4, were discovered in (Arthur et al, 2009Kapoor et al, 2009Kapoor et al, , 2010.…”

Section: Introductionmentioning

confidence: 99%

“…PCR is the most common method used to detect acute infections of HBoV1 (Bastien et al, 2006;Kesebir et al, 2006;Allander et al, 2007;Fry et al, 2007;Schildgen et al, 2008). However, HBoV1 DNA has been shown to remain detectable by PCR in respiratory samples for several months after primary infection (Brieu et al, 2008;Blessing et al, 2009;Lehtoranta et al, 2012;Martin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Original antigenic sin with human bocaviruses 1–4

Kantola

Hedman

et al. 2015

Journal of General Virology

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Human bocavirus (HBoV) 1 is a widespread parvovirus causing acute respiratory disease in young children. In contrast, HBoV2 occurs in the gastrointestinal tract and is potentially associated with gastroenteritis, whilst HBoV3 and -4 infections are less frequent and have not yet been linked with human disease. Due to HBoV1 DNA persistence in the nasopharynx, serology has been advocated as a better alternative for diagnosing acute infections. In constitutionally healthy children, we previously noted that pre-existing HBoV2 immunity in a subsequent HBoV1 infection typically resulted in low or non-existent HBoV1-specific antibody responses. A phenomenon describing such immunological events among related viruses has been known since the 1950s as 'original antigenic sin' (OAS). The aim of this study was to characterize this putative OAS phenomenon in a more controlled setting. Follow-up sera of 10 rabbit pairs, inoculated twice with HBoV1-4 virus-like particles (VLPs) or control antigens, in various combinations, were analysed with HBoV1-4 IgG enzyme immunoassays with and without depletion of heterotypic HBoV antibodies. There were no significant IgG boosts after the second inoculation in either the heterologously or the homologously HBoV-inoculated rabbits, but a clear increase in cross-reactivity was seen with time. We could, however, distinguish a distinct OAS pattern from plain cross-reactivity: half of the heterologously inoculated rabbits showed IgG patterns representative of the OAS hypothesis, in line with our prior results with naturally infected children. HBoVs are the first parvoviruses to show the possible existence of OAS. Our findings provide new information on HBoV1-4 immunity and emphasize the complexity of human bocavirus diagnosis.

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Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

Abstract: HBoV infection was epidemiologically associated with pneumonia among young children in rural Thailand, but infection and illness may be dependent on coinfection with other viruses.

Cited by 268 publications

References 22 publications

Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses

Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses

Detección de bocavirus humano en la población infantil de Tucumán y Santa Fe, Argentina

Original antigenic sin with human bocaviruses 1–4

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