Human biomonitoring of phthalate exposure in Austrian children and adults and cumulative risk assessment

Hartmann, Christina; Uhl, Maria; Weiß, Stefan; Koch, Holger M.; Scharf, Sigrid; König, Jürgen

doi:10.1016/j.ijheh.2015.04.002

Cited by 101 publications

(52 citation statements)

References 55 publications

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“…First, DEHP oxidative metabolites are of higher stability and sensitivity in determination, whereas MEHP has a shorter serum half-life than the other metabolites [40]. The detection rates of four DEHP oxidative metabolites (MEOHP, MECPP, MEHHP, MCMHP) in our samples were similar to the relevant studies published from 2007 to 2016, which were all above 90% [39,41,42,43,44,45]. Second, it has been reported that MEHHP and MEOHP was more active in animals than MEHP [46].…”

Section: Discussionsupporting

confidence: 78%

Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults

Dong

Zhao

Zhang

et al. 2017

IJERPH

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Phthalate exposure was reported to be associated with diabetes mellitus (DM) and cardiovascular disease (CVD). Yet, reported associations and the potential sex differences are inconsistent. We conducted a cross-sectional study involving 2330 participants in the Fall of 2012. Urinary metabolites of 10 phthalates were measured. The status of having DM and CVD-related outcomes were self-reported. In the overall study population, the logistic regression analyses showed that the urinary levels of mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate(MEHHP) and mono-2-ethyl-5-carboxypentylphthalate (MECPP) were positively associated with DM. Higher urinary levels of monomethyl phthalate (MMP) and mono-2-carboxymethyl-hexyl phthalate (MCMHP) were associated with increased odds of hyperlipidemia, while mono-2-ethylhexylphthalate (MEHP) was significantly inverse-associated with hyperlipidemia. We did not observe significant associations for other CVD-related outcomes with phthalate metabolites. When stratifying by sex, MEHHP, MEOHP, MECPP, MCMHP and the micromolar sums of the oxidative metabolites of DEHP (ΣDEHPox) were all significantly related to DM in males, but not in females. No significant sex differences were found in CVD-related outcomes, except the sporadic associations between phthalates and hyperlipidemia. These findings highlight the importance of investigating the sex-specific relationship between phthalates exposure and DM.

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Section: Discussionsupporting

confidence: 78%

Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults

Dong

Zhao

Zhang

et al. 2017

IJERPH

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“…In Kaohsiung, Wu et al, measured higher DEHP daily intake levels (median: 11.8 μg/kg bw/day) in children aged 1–10 years and recruited immediately as the phthalate episode occurred [27]. In Australia, daily DEHP intake was reportedly higher in children at the age of 6–15 years old than those in our study [28]. However, lower DEHP exposure levels were reported in Greek children aged 2 years old [29] and in German children 5–6 years old [30].…”

Section: Discussionmentioning

confidence: 45%

Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan

Wen

Chen

et al. 2017

PLoS ONE

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BackgroundIn May 2011, a major incident involving phthalates-contaminated foodstuffs occurred in Taiwan. Di-(2-ethylhexyl) phthalate (DEHP) was added to foodstuffs, mainly juice, jelly, tea, sports drink, and dietary supplements. Concerns arose that normal pubertal development, especially reproductive hormone regulation in children, could be disrupted by DEHP exposure.ObjectiveTo investigate the association between phthalate exposure and reproductive hormone levels among children following potential exposure to phthalate-tainted foodstuffs.MethodsA total of 239 children aged <12 years old were recruited from 3 hospitals in north, central, and south Taiwan after the episode. Structured questionnaires were used to collect the frequency and quantity of exposures to 5 categories of phthalate-contaminated foodstuffs to assess phthalate exposure in children. Urine samples were collected for the measurement of phthalate metabolites. The estimated daily intake of DEHP exposure at the time of the contamination incident occurred was calculated using both questionnaire data and urinary DEHP metabolite concentrations. Multiple regression analyses were applied to assess associations between phthalate exposure and reproductive hormone levels in children.ResultsAfter excluding children with missing data regarding exposure levels and hormone concentrations and girls with menstruation, 222 children were included in the statistical analyses. After adjustment for age and birth weight, girls with above median levels of urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and sum of mono-(2-ethylhexyl) phthalate concentrations had higher odds of above median follicle-stimulating hormone concentrations. Girls with above median estimated average daily DEHP exposures following the contamination episode also had higher odds of sex hormone-binding globulin above median levels.ConclusionsPhthalate exposure was associated with alterations of reproductive hormone levels in girls.

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“…Dewalque et al [37], Hartmann et al [38], and Wang et al [39] provided examples of current CRAs of phthalate exposure in geographically distinct populations; Dewalque et al [37] and Hartmann et al [38] addressed phthalate mixtures in the Belgian and Austrian general populations respectively, while Wang et al [39] focused on children in three areas in China, finding that children living in manufacturing intensive areas are at a highest risk of phthalate exposure. Pelallo-Martinez et al [40], also focusing on children in industrial areas, used urinary biomarkers to assess exposure to a mixture of lead, benzene, toluene, and polyaromatic hydrocarbons (PAHs), and find that variation in the levels of PAHs in the mixture modifies the genotoxic and hematological effects of exposure.…”

Section: Results—human Healthmentioning

confidence: 99%

An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)

Fox

Brewer

Martin

2017

IJERPH

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Cumulative risk assessments (CRAs) address combined risks from exposures to multiple chemical and nonchemical stressors and may focus on vulnerable communities or populations. Significant contributions have been made to the development of concepts, methods, and applications for CRA over the past decade. Work in both human health and ecological cumulative risk has advanced in two different contexts. The first context is the effects of chemical mixtures that share common modes of action, or that cause common adverse outcomes. In this context two primary models are used for predicting mixture effects, dose addition or response addition. The second context is evaluating the combined effects of chemical and nonchemical (e.g., radiation, biological, nutritional, economic, psychological, habitat alteration, land-use change, global climate change, and natural disasters) stressors. CRA can be adapted to address risk in many contexts, and this adaptability is reflected in the range in disciplinary perspectives in the published literature. This article presents the results of a literature search and discusses a range of selected work with the intention to give a broad overview of relevant topics and provide a starting point for researchers interested in CRA applications.

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Human biomonitoring of phthalate exposure in Austrian children and adults and cumulative risk assessment

Cited by 101 publications

References 55 publications

Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults

Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults

Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan

An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)

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