Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Louro, Henriqueta; Heinälä, Milla; Bessems, Jos; Buekers, Jurgen; Vermeire, Theo; Woutersen, Marjolijn; Engelen, Jacqueline van; Borges, Teresa; Rousselle, Christophe; Ougier, Eva; Alvito, Paula; Martins, Carla; Assunção, Ricardo; Silva, Maria João; Pronk, Anjoeka; Schaddelee-Scholten, B.; González, Marı́a del Carmen; Alba, Mercedes de; Castaño, Argelia; Viegas, Susana; Humar-Juric, T.; Kononenko, L. V.; Lampen, Alfonso; Vinggaard, Anne Marie; Schoeters, Greet; Kolossa-Gehring, Marike; Santonen, Tiina

doi:10.1016/j.ijheh.2019.05.009

Cited by 124 publications

(81 citation statements)

References 13 publications

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“…When standardized guidelines become available for measuring many chemicals simultaneously and high throughput analyses exist, then identification of new dose-response relationships may be possible, linking chemical body burden to specific health outcomes. Certainly, BM may contribute significantly to further developing quantitative risk assessments [7].…”

Section: Additional Information That Biomonitoring Provides When Assementioning

confidence: 99%

“…In occupational health interventions, BM can assist in the evaluation and demonstration of the effectiveness of policy actions, measures already taken at a company level to reduce exposure and the detection of emerging and well-known contaminants. Additionally, and since BM considers aggregated exposures (exposure to the same substance from different sources and by different exposure routes), it provides a comprehensive exposure picture compared to ambient monitoring (e.g., air monitoring, surfaces contamination measurement, skin contamination) [2,7].…”

Section: Introductionmentioning

confidence: 99%

“…BM of occupational exposure to chemicals is a longstanding practice in occupational health risk assessment and occupational health practice [7]. However, there are wide differences in its use between different countries, as identified in a recent European Commission (EC) survey aimed at understanding BM usage in Europe [13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context—Challenges and Way Forward

Viegas,

Zare Jeddi,

B. Hopf

et al. 2020

IJERPH

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Recent advances in analytical chemistry have allowed a greater possibility of using quantitative approaches for measuring human exposure to chemicals. One of these approaches is biomonitoring (BM), which provides unequivocal evidence that both exposure and uptake of a chemical have taken place. BM has been a longstanding practice in occupational health for several reasons. BM integrates exposure from all routes. It can help identify unintentional and unexpected exposures and assess the effectiveness of existing risk-management measures. BM also provides relevant information to support policy development by delivering better evidence of workers’ exposure to chemical substances, even within the framework of the present regulations. Thus, BM can allow for both the evaluation of the impact of regulation and identification of further needs for new or improved regulation. However, despite all these well-recognized advantages, BM is currently an underused exposure assessment tool. This paper provides an overview of the key aspects to be considered when using BM in the context of occupational health interventions. Additionally, this paper describes the potential of BM as an exposure assessment tool, distinguishing the role of BM in exposure assessment and health surveillance and clarifies ethical and communication aspects to guarantee that general data protection regulations are followed. In addition, actions and research needs are identified (particularly with reference to the European situation), which aim to encourage the increased use of BM as an exposure assessment tool.

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Section: Additional Information That Biomonitoring Provides When Assementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context—Challenges and Way Forward

Viegas,

Zare Jeddi,

B. Hopf

et al. 2020

IJERPH

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“…The study concluded suggesting enhancement of data by encouraging volunteers to provide ancillary data sets. Louro et al (2019) presented the results of a survey conducted among national regulatory risk assessors. The survey was aimed at collecting information from assessors and to understand their practices of risk assessment.…”

Section: Regulatory Agency Guidance Standard and Policymentioning

confidence: 99%

Ecological and human health risk assessment

Choudri

Al‐Nasiri

Charabi

et al. 2020

Water Environment Research

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The literature review presented in this paper includes the ecological and human health risk assessment in the form of receptors in the environment. The main objective of this review to highlight a summary of the many studies undertaken in the year 2019. The first part of the review covers the papers published on the health risk assessment related to human and ecological health. This article focuses on methods and tools utilized for the analysis of scientific studies and the data. The review provides main issues such as interpretation of data, uncertainty, and policies related to the management of risks. The ecological and human health risk assessment is divided into two main sections. Each of these sections presents in broad the risk assessment process namely pollution studies, remediation, and tools required for the management of natural resources and the environment.

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“…Such preclinical alterations may function both as indicators of early effects before J o u r n a l P r e -p r o o f clinical manifestations may occur and as indirect markers of exposure, although with a low specificity for ENMs (Schulte et al 2019). Several reports suggested the usefulness of biological monitoring to survey populations exposed to chemical hazards (Boogaard et al 2011;Louro et al 2019), in particular to emerging hazards with unknown toxicity, such as ENMs (Bergamaschi et al 2015;Schulte et al 2018;Schulte et al 2016). Biomarkers of early adverse effects appears relevant to anticipate and indicate some negative health effects consequences that might accompany increasing production and use of ENMs in unprotected areas.…”

Section: Introductionmentioning

confidence: 99%

Reference ranges of oxidative stress biomarkers selected for non-invasive biological surveillance of nanotechnology workers: Study protocol and meta-analysis results for 8-OHdG in exhaled breath condensate

et al. 2020

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Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Cited by 124 publications

References 13 publications

Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context—Challenges and Way Forward

Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context—Challenges and Way Forward

Ecological and human health risk assessment

Reference ranges of oxidative stress biomarkers selected for non-invasive biological surveillance of nanotechnology workers: Study protocol and meta-analysis results for 8-OHdG in exhaled breath condensate

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