Human biomonitoring data analysis for metals in an Italian adolescents cohort: An exposome approach

Pino, Anna; Chiarotti, Flavia; Calamandrei, Gemma; Gotti, Alberto; Karakitsios, Spyros; Handakas, Evangelos; Bocca, Beatrice; Sarigiannis, D; Alimonti, Andrea

doi:10.1016/j.envres.2017.08.012

Cited by 34 publications

(11 citation statements)

References 47 publications

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“…A Danish study reported concentrations of 1.79μg L -1 for Sn-B (n = 10), and 0.34μg L -1 Sn-U (n = 29) 24 , performed only with women in reproductive age. Geometric means (95% confidence interval) obtained for Sn-B among Italian urban adolescents (13-15 years) were similar; values found were 0.76 (0.67-0.87) in boys and 0.75 (0.66-0.84) in girls 25 . No other studies were found comparing tin concentration in men and women; however, significant differences have been found between men and women exposed to other metals 26,27 .…”

Section: Biological Samplesmentioning

confidence: 64%

Spatial pattern of the environmental exposure to tin in the vicinity of an alloy industry in Volta Redonda, Rio de Janeiro State, Brazil

2019

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Despite being widely used in industry, the literature on tin and its effects in humans is scarce, especially regarding reference values in biological indicators such as blood and urine. Similarly, environmental limits are also rare. This study sought to assess the spatial distribution of hotspots in the environmental exposure to tin in the vicinity of an alloy industry in the south region of the state of Rio de Janeiro, Brazil. The study population consisted of 74 adults. Graphite furnace atomic absorption spectrometry determined tin in all samples. Households and points around the industry were georeferenced with the use of GPS to identify the most intense tin sites. Results of the first and second campaigns ranged from 0.022 to 0.153 and 0.003 to 0.445µg m-3 for the atmospheric air, whereas such ranges were 0.64 to 1.61 and 1.97 to 8.54µg m-2 for household dust, respectively. The mean tin concentration found in the blood of the population was 3.85 ± 1.57µg L-1. In urine the value was 3.56 ± 1.88µg L-1. The kernel map showed the highest spatial concentrations of tin in household dust in the eastern region of the industry. In the first sampling, atmospheric air samples presented the most elevated concentrations in the southwest and southeast. Although the direction of the wind was northwest, potentially high risks were concentrated in the central area in the second collection. The largest hotspots were in the north, south and southeast regions; however, urine samples showed medium to high levels in the west and east regions. Regarding blood samples, the greatest difference was the absence of hotspot areas in the west. Environmental monitoring becomes necessary to better assess the exposure to tin.

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Section: Biological Samplesmentioning

confidence: 64%

Spatial pattern of the environmental exposure to tin in the vicinity of an alloy industry in Volta Redonda, Rio de Janeiro State, Brazil

2019

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“…One article investigated genome-environment interactions using pre-identified factors from GWAS and EWAS (Patel et al, 2013a). One article carried out an outcome-wide association study to screen which environmental sources could be potentially used to derive biomarkers (Pino et al, 2017). Finally, a total of 23 articles were included in this systematic review.…”

Section: Search Resultsmentioning

confidence: 99%

Design and methodology challenges of environment-wide association studies: A systematic review

Zheng

Chen

Pearson

et al. 2020

Environmental Research

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Environment-wide association studies (EWAS) are an untargeted, agnostic, and hypothesisgenerating approach to exploring environmental factors associated with health outcomes, akin to genome-wide association studies (GWAS). While design, methodology, and replicability standards for GWAS are established, EWAS pose many challenges. We systematically reviewed published literature on EWAS to categorize scope, impact, types of analytical approaches, and open challenges in designs and methodologies. The Web of Science and PubMed databases were searched through multiple queries to identify EWAS articles between January 2010 and December 2018, and a systematic review was conducted following the Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) reporting standard. Twenty-three articles met our inclusion criteria and were included. For each study, we categorized the data sources, the definitions of study outcomes, the sets of environmental variables, and the data engineering/ analytical approaches, e.g. neighborhood definition, variable standardization, handling of multiple hypothesis testing, model selection, and validation. We identified limited exploitation of data sources, high heterogeneity in analytical approaches, and lack of replication. Despite of the promising utility of EWAS, further development of EWAS will require improved data sources, standardization of study designs, and rigorous testing of methodologies.

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“…Seventeen of the retained studies had a cross-sectional design (21%) [73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89], and twelve were experimental (15%) (i.e., three randomized trials on metabolomic profile alterations [90,91] or clinical health outcomes [92] following administration of the experimental exposure; two open label cross-over trials exploring metabolomic and clinical effects of an experimental (juice) [93,94] or environmental (airborne and grass pollen) intervention [95], and seven experimental non-randomized studies). Five studies were case-control (6%) [94,[96][97][98][99] and three case-control studies nested in cohorts (4%) [100][101][102].…”

Section: Description Of the Selected Articlesmentioning

confidence: 99%

“…Novel agnostic tools of the exposome characterization were extensively used in 16 studies (20%), where 9 exposome studies (11%) employed the EWAS approach [50,63,73,61,67,69,79,86,107]; 3(4%) studies used the GWAS approach [71,78,92] and 2 (3%) used the so-called MWAS approach [84,88]; another publication (1%) [59] reported the use of an exposome-metabolome wide association study, and another one (1%) [108] employed both an EWAS and a GWAS approach.…”

Section: Interventionsmentioning

confidence: 99%

“…Environmental factors were examined in association with gene expression profiling in four studies (5%)[65,71,78,108]. Five studies (6%) aimed to identify clusters of exposures, of which one was examined in association with obesity and another one with type II diabetes and all-cause mortality[8,54,61,86,107].In addition, twelve studies (16%) aimed to characterize the endogenous response to a variety of environmental stimuli, such as endocrine disruptors (phthalate metabolites, phenols), non-persistent chemicals (dialkyl phosphate pesticides metabolites, and cotinine), and other environmental chemicals, such as organochlorine compounds (OCs), polybrominated diphenyl ethers (PBDEs), per-and poly-fluoroalkyl…”

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confidence: 99%

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A Scoping Review on the Characteristics of Human Exposome Studies

2019

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Embraced as a breaking through methodological framework, the exposome is accompanied by novel exposure assessment methods and data processing tools or models. However, systematic mapping of the landscape of exposome studies, including their characteristics, components, tools and language has not been done so far. We conducted a scoping review to answer the question: "Which main domains of the human exposome have been included in the literature and which metrics of exposure(s)/ outcome(s) have been used?" We performed a comprehensive search of human studies containing the word "exposom*" and published up to March 8, 2019. We screened 1133 records and 82 studies were included in the analysis. Most studies took place in Europe. Data analysis showed the non-systematic use of the exposome term. Most studies had a longitudinal design (n = 30, 37%), were conducted on adults (n = 40, 51%), and had a clearly defined health outcome in methodology (n = 48, 61%). Omics tools, such as metabolomics were used in 38 studies (49%), while environment-wide association analysis was used in 9 studies (11%). Thirty-seven (48%) studies included all three exposome domains (general external, specific external and internal) while 33 (42%) studies included two. Despite the large number of environmental components that comprise each of the exposome domains, only a subset has been currently studied. An optimized consideration of the components from all exposome domains, as well as the standardization of the exposure and outcome assessment methods is warranted to advance the utility of the human exposome concept.

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Human biomonitoring data analysis for metals in an Italian adolescents cohort: An exposome approach

Cited by 34 publications

References 47 publications

Spatial pattern of the environmental exposure to tin in the vicinity of an alloy industry in Volta Redonda, Rio de Janeiro State, Brazil

Spatial pattern of the environmental exposure to tin in the vicinity of an alloy industry in Volta Redonda, Rio de Janeiro State, Brazil

Design and methodology challenges of environment-wide association studies: A systematic review

A Scoping Review on the Characteristics of Human Exposome Studies

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