Human basophil/mast cell releasability. XI. Heterogeneity of the effects of contrast media on mediator release

Stellato, Cristiana; Crescenzo, Gennaro de; Patella, Vincenzo; Mastronardi, P; Mazzarella, B; Marone, Gianni

doi:10.1016/s0091-6749(96)80162-x

Cited by 102 publications

(105 citation statements)

References 42 publications

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“…8,9 Salbutamol, beclomethasone and sodium chromoglycate are used routinely in the management of bronchospasm. Therefore, we postulated that aerosol inhalation of these drugs would prevent fentanyl-induced cough.…”

Section: Objectif : Le Fentanyl Un Opioïde Synthétique Est Très Utimentioning

confidence: 99%

Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced byiv fentanyl

Agarwal

Azim

Ambesh

et al. 2003

Can J Anesth/J Can Anesth

102

122

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P Pu ur rp po os se e: : Fentanyl, a synthetic opioid, is a popular choice amongst anesthesiologists in the operating room. Preinduction iv fentanyl bolus is associated with coughing in 28-45% of patients. Coughing due to fentanyl is not always benign and at times may be explosive requiring immediate intervention. We have studied the role of aerosol inhalation of salbutamol, beclomethasone and sodium chromoglycate in preventing fentanyl induced coughing and have compared their efficacy.M Me et th ho od ds s: : Two hundred patients aged 18-60 yr, undergoing elective laparoscopic cholecystectomy were randomized into four groups of 50 each. Group I served as control, while Groups II, III and IV received an aerosol inhalation of salbutamol, beclomethasone or sodium chromoglycate 15 min prior to entering the operating room. Following iv fentanyl (2 µg·kg -1 ) the incidence of cough was recorded and graded as mild (1-2), moderate (3-5) and severe (> 5) depending on the number of coughs observed. Results were analyzed using 'z' and Fischer's Exact test. A P value of # 0.05 was considered significant. R Re es su ul lt ts s: : The incidence of cough was 28% in the control group, 6%, 0% and 4% in the salbutamol, beclomethasone and sodium chromoglycate groups respectively. Occurrence of cough was significantly low (P # 0.05) in the treatment groups, however the difference amongst the groups was not significant (P $ 0.05).

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Section: Objectif : Le Fentanyl Un Opioïde Synthétique Est Très Utimentioning

confidence: 99%

Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced byiv fentanyl

Agarwal

Azim

Ambesh

et al. 2003

Can J Anesth/J Can Anesth

102

122

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“…20 Interestingly, the various opioids differ in their capacity to release histamine, which suggests that the mechanism is not immunologic. 21 In the pruritic dermatoses, opioids and endorphins have not been conclusively implicated in the production of itch. However, opioid antagonists, such as naloxone, naltrexone, ondansetron, and rifampicin, effectively control opioid-induced pruritus.…”

Section: Opioids and Endorphinsmentioning

confidence: 99%

Pruritic dermatoses: overview of etiology and therapy

Charlesworth¹,

Beltrani

2002

The American Journal of Medicine

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This review begins with a brief survey of the neurophysiology and neuroanatomy of pruritus, and goes on to describe the etiology of the major allergic and nonallergic pruritic disorders. The etiology of pruritus often suggests the appropriate treatment. For example, urticaria, which is primarily mediated by histamine, is amenable to treatment with H 1 antihistamines. Second-generation, nonsedating antihistamines appear to be more effective than sedating antihistamines, perhaps because of better compliance. Other systemic pharmacologic options may be useful in nonhistamine-mediated disorders, for example, immunomodulators for inflammation-induced pruritus or opiate antagonists for atopic dermatitis. Nonpharmacologic measures, such as proper skin care, and physical modalities, such as phototherapy or acupuncture, may also be helpful. Am J Med. 2002;113(9A):25S-33S.

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“…Moreover, for many years, codeine has been a positive control for skin prick testing (SPT) (11) and SPT has been argued to be of no value in opiate sensitivity (12). In contrast, opioids such as morphine and diamorphine (heroin) and buprenorphine seem not to trigger histamine release from human basophils (13,14). Alternatively, pholcodine-specific IgE antibodies have been demonstrated in not less than 6% of blood donors from Norway (15) where the antitussive was over-the-counter available until 2007.…”

mentioning

confidence: 99%

IgE‐mediated allergy to pholcodine and cross‐reactivity to neuromuscular blocking agents: Lessons from flow cytometry

Leysen

Witte

Sabato

et al. 2013

Cytometry Part B Clinical

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Background: Immunoglubulin E antibody-mediated allergic reactions to opioids are rare and difficult to document correctly.Objective: Assessment of the basophil activation test in the diagnosis of IgE-mediated allergy to the antitussive pholcodine and associated sensitizations to neuromuscular blocking agents (NMBA).Methods: Three patients with a suspected IgE-mediated allergy to pholcodine were investigated using skin tests, quantification of specific IgE, and flow cytometric activation of basophils.Results and conclusion: Flow cytometric activation of basophils, with simultaneous analysis of CD63 appearance and median histamine content per cell, is the only technique capable to correctly document pholcodine allergy. The negative predictive value of basophil activation tests might help to elucidate on the controversial putative cross-reactivity between pholcodine and NMBA. V C 2013 International Clinical

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Human basophil/mast cell releasability. XI. Heterogeneity of the effects of contrast media on mediator release

Cited by 102 publications

References 42 publications

Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced byiv fentanyl

Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced byiv fentanyl

Pruritic dermatoses: overview of etiology and therapy

IgE‐mediated allergy to pholcodine and cross‐reactivity to neuromuscular blocking agents: Lessons from flow cytometry

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