Human babesiosis: clinical cases in the european part of the Russian Federation

Tokmalaev, A K; Chentsov, V B; Малов, В А; Maleyev, V V; Кожевникова, Г М; Polovinkina, N A; Golub, V P; Konnov, V V; Kharlamova, Т. V.

doi:10.26442/00403660.2019.11.000405

Cited by 4 publications

(2 citation statements)

References 33 publications

(39 reference statements)

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“…несмотря на то, что бабезиозы являются распространенными протозоозами диких и домашних животных, простейшие рода Babesia (например, В. microti) могут представлять опасность для человека. известно, что патогенные для человека бабезии передаются преимущественно клещами рода Ixodes (I. ricinus, I. persulcatus) [15]. однако общность резервуарных хозяев в зоне симпатрии иксодовых клещей определяет роль D. reticulatus в качестве возможного вектора для данного патогена, что, в частности, подтверждается результатами нашего исследования.…”

Section: результаты и обсуждениеunclassified

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Voronkova,

Romanenko,

Simakova

et al. 2023

Problemy Osobo Opasnykh Infektsii

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The aim of the study was to characterize mono- and mixed infection with causative agents of vector-borne infections in Dermacentor reticulatus ticks inhabiting one of the anthropourgic foci of the Tomsk Region. Materials and methods. D. reticulatus ticks were collected from vegetation “on the flag” in the forest park zones of the southern part of Tomsk in August and September, 2020–2021. To isolate nucleic acids from homogenates of mites and subsequent PCR diagnostics, kits of the RealBest series (“Vector-Best”, Novosibirsk) were used. 184 individual samples of nucleic acids were examined for the presence of molecular-genetic markers of tick-borne encephalitis virus (TBEV), pathogenic borrelia, babesia, rickettsia, anaplasma, and ehrlichia. Results and discussion. The spectrum of pathogens detected through PCR assay of ticks collected in one of the anthropurgic foci of the Tomsk Region in 2020 and 2021 includes TBEV, pathogenic borrelia, rickettsia, and babesia. The highest rate of D. reticulatus infection has been established in relation to candidate pathogens of tick-borne rickettsioses (Rickettsia sp.) and babesioses (Babesia sp.). The overall frequency of co-infection in D. reticulatus was 12.88 %. Seven different associations of pathogens infecting D. reticulatus have been identified. The majority (88.24 %) of the detected cases of mixed infection were rickettsia associations. Double infection has been registered in 94 % of the total number of mixed variants. Markers of four tick-borne infection pathogens simultaneously (Rickettsia species DNA, Babesia species DNA, Borrelia burgdorferi s.l. DNA and TBEV RNA) have been found in one sample. Changes in areal of the D. reticulatus against the background of an increase in their numbers, determines the need to analyze the epidemiological significance of the ticks of this species in combined foci of tick-borne infections, especially in the zone of sympatry with ixodic ticks of other species.

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Section: результаты и обсуждениеunclassified

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Voronkova,

Romanenko,

Simakova

et al. 2023

Problemy Osobo Opasnykh Infektsii

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“…Two cases reported as B. bovis infections were diagnosed on the basis of their appearance under the microscope only, rendering their identity questionable [ 1 , 100 ]. Even after 1998, at least 26 more cases were published as human babesiosis, despite diagnostic deficiencies or with lack of clarity, including 2 case reports of B. microti from Russia [ 101 ], 1 case from Spain [ 102 ] and 10 cases of unknown Babesia spp. from Montenegro [ 103 ], which were only diagnosed microscopically.…”

Section: Epidemiologymentioning

confidence: 99%

Human Babesiosis in Europe

et al. 2021

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Babesiosis is attracting increasing attention as a worldwide emerging zoonosis. The first case of human babesiosis in Europe was described in the late 1950s and since then more than 60 cases have been reported in Europe. While the disease is relatively rare in Europe, it is significant because the majority of cases present as life-threatening fulminant infections, mainly in immunocompromised patients. Although appearing clinically similar to human babesiosis elsewhere, particularly in the USA, most European forms of the disease are distinct entities, especially concerning epidemiology, human susceptibility to infection and clinical management. This paper describes the history of the disease and reviews all published cases that have occurred in Europe with regard to the identity and genetic characteristics of the etiological agents, pathogenesis, aspects of epidemiology including the eco-epidemiology of the vectors, the clinical courses of infection, diagnostic tools and clinical management and treatment.

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Babesiosis in humans (lecture)

2023

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Бабезиоз -природно-очаговое инфекционное заболевание, вызываемое простейшими рода Babesia, передающееся трансмиссивным путем и характеризующееся лихорадкой, интоксикацией, прогрессирующей гемолитической анемией и часто тяжелым течением у пациентов с иммунодефицитными состояниями. Клиническая картина бабезиоза неспецифична. Заболевание следует заподозрить у пациентов с необъяснимой лихорадкой, которые находились в эндемичных районах в течение 2 месяцев или получили переливание крови в течение 6 месяцев. Диагностика бабезиоза сложна; зависит от квалификации врача и от количества паразитов в крови. Целью работы является обобщение имеющихся сведений об этиологии, эпидемиологии, патогенезе, клинике, диагностике, этиотропной терапии и профилактике бабезиоза у человека. Проведен обзор отечественной и зарубежной литературы за последние 30 лет, в том числе Интернет-ресурсов.

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Human babesiosis: clinical cases in the european part of the Russian Federation

Cited by 4 publications

References 33 publications

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Human Babesiosis in Europe

Babesiosis in humans (lecture)

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