2018
DOI: 10.1101/272591
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Human axial progenitors generate trunk neural crest cells

Abstract: 29The neural crest (NC) is a multipotent embryonic cell population generating distinct cell types 30 in an axial position-dependent manner. The production of NC cells from human pluripotent 31 stem cells (hPSCs) is a valuable approach to study human NC biology. However, the origin 32

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Cited by 2 publications
(2 citation statements)
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References 96 publications
(132 reference statements)
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“…Recent work on multipotent zebrafish neural crest cells suggests that at least a portion of the neural biased trunk neural crest (NC) progenitors arise from early neural biased zebrafish NMps at 5-6ss ( Lukoseviciute et al., 2021 ). A similar conclusion was reached in multiple studies of in vitro human pluripotent stem cell-derived axial progenitors, demonstrating that the generation of trunk NCs involves an obligatory NMp intermediate ( Frith et al., 2018 ; Hackland et al., 2019 ). We identified sp5l , cdh6 , znf703 and foxd3 as differentially expressed genes of the NMp cluster; all of which have important roles in neural crest specification.…”
Section: Discussionsupporting
confidence: 71%
“…Recent work on multipotent zebrafish neural crest cells suggests that at least a portion of the neural biased trunk neural crest (NC) progenitors arise from early neural biased zebrafish NMps at 5-6ss ( Lukoseviciute et al., 2021 ). A similar conclusion was reached in multiple studies of in vitro human pluripotent stem cell-derived axial progenitors, demonstrating that the generation of trunk NCs involves an obligatory NMp intermediate ( Frith et al., 2018 ; Hackland et al., 2019 ). We identified sp5l , cdh6 , znf703 and foxd3 as differentially expressed genes of the NMp cluster; all of which have important roles in neural crest specification.…”
Section: Discussionsupporting
confidence: 71%
“…Recent work on multipotent zebrafish neural crest cells suggests that at least a portion of the neural biased trunk neural crest (NC) progenitors arise from early neural biased zebrafish NMps at 5-6ss (Lukoseviciute et al, 2021). A similar conclusion was reached in multiple studies of in vitro human pluripotent stem cellderived axial progenitors, demonstrating that the generation of trunk NCs involves an obligatory NMp intermediate (Frith et al, 2018;Hackland et al, 2019). We identified sp5l, cdh6, znf703 and foxd3 as differentially expressed genes of the NMp cluster; all of which have important roles in neural crest specification.…”
Section: Discussionmentioning
confidence: 72%