Human auto‐anti‐idiotypic antibodies to mite‐specific IgE can degranulate human basophils <i>in vitro</i>

Weyer, A.; Mao, J. Le; Etiévant, M; David, B.; Guinnepain, M.T.; Saint-Remy, Jean-Marie

doi:10.1111/j.1365-2222.1995.tb00395.x

Cited by 12 publications

(4 citation statements)

References 28 publications

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“…It has been suggested that they play a putative role in IgE synthesis regulation, via the IgE receptor (FcεRI or CD23) on B lymphocytes, or via inflammatory cells, like mast cells, eosinophils or neutrophils. 16–18 These autoantibodies also seem to have a regulatory influence on human IgE mRNA synthesis as well as interleukin‐4‐induced proliferation of human mononuclear cells. 24 However, to date, interactions between IgE antibodies and IgE autoantibodies in atopic patients are not clear.…”

Section: Discussionmentioning

confidence: 99%

Oral tolerance induced to house dust mite extract in naive and sensitized mice: evaluation of immunoglobulin G anti‐immunoglobulin E autoantibodies and IgG–IgE complexes

et al. 1998

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We investigated the effect on specific antibody response of naive and sensitized mice orally administrated with low (0.25 mg) or high (10.0 mg) doses of Dermatophagoides pteronyssinus (Dp) extract. We also examined the effect of oral administration of Dp on the production of autoantibodies to immunoglobulin G (IgG) and immunoglobulin E (IgE). Naive and sensitized mice both showed a marked down-regulation of IgE antibody production, regardless of the dose of Dp. We also detected an inhibitory effect of the total IgE levels and the allergen-specific IgG1, IgG2a and IgG2b antibody response in sensitized mice given the low dose of Dp. In contrast, high doses of Dp stimulated IgG1 antibody production in both naive and sensitized animals. In addition, the oral tolerance induction protocol stimulated anti-F(ab')2gamma and anti-Fcgamma autoantibody production. Evaluation of IgG anti-IgE autoantibodies by a direct enzyme immunoassay (EIA) revealed the presence of these autoantibodies, predominantly of the IgG1 isotype, specifically in those animals fed with the high dose. In contrast, IgG-IgE complexes, determined by EIA using immobilized anti-IgE antibodies, were detected mainly in sera of control animals. The autoantibody anti-IgE specificity was tested against IgE-TNP and IgE-DANSYL murine proteins and revealed different inhibition profiles, suggesting the action of heterogeneous subpopulations of autoantibodies. Taken together, our results show that the oral tolerance protocol with Dp was able to modulate the production of allergen-specific IgE antibodies in both naive and sensitized animals. In addition, we suggest that anti-IgE autoantibodies participate in the modulation of allergic response triggered by oral tolerance protocols.

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Section: Discussionmentioning

confidence: 99%

Oral tolerance induced to house dust mite extract in naive and sensitized mice: evaluation of immunoglobulin G anti‐immunoglobulin E autoantibodies and IgG–IgE complexes

et al. 1998

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“…The capability of human anti-idiotypic IgG purified from mite allergic patients to recognize cell bound IgE idiotypes of other donors, and to induce mediator release of basophils in the absence of allergen was demonstrated 29. Consequently, the possibility that degranulation in response to anti-ids could be a general event in allergy was proposed.…”

Section: The Functional Role Of Anti-ids In Allergymentioning

confidence: 99%

Anti-Ids in Allergy: Timeliness of a Classic Concept

Wallmann

Pali‐Schöll

Jensen‐Jarolim

2010

World Allergy Organization Journal

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Abstract:Anti-idiotypic antibodies (anti-ids) are part of natural immune responses with regulatory capacity. Their effect on an antigen-specific, so-called Ab1 antibody response, is dependent on 1) the original antigen, which they mirror, being Ab2 antibodies, and 2) their isotype. In the case of IgE-mediated allergy, natural anti-ids against allergen-specific IgE represent internal images of allergen molecules. A key biologic feature of allergens is that they can crosslink IgE, expressed by B-lymphocytes or passively bound via high affinity receptors to effector cells, which renders cellular activation. Therefore, the IgE cross linking capability of anti-ids determines whether they dampen or enhance immediate-type hypersensitivity. Correspondingly to classic antiallergen blocking IgG antibodies, anti-ids may also interact with inhibitory FcγRIIb receptors and, thereby, down-regulate TH2-type inflammation. Anti-ids and other B-cell epitope mimetics, like mimotopes and DARPins, represent antigen surrogates, which can be used for vaccination. Intriguingly, they may induce antibody responses without activating potentially proinflammatory, antiallergen T-lymphocytes. Taken together, collective evidence suggests that anti-ids, although representing immunologic classics, are a timeless concept in allergology.

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“…Thus, the Dactylis pollen affinity chromatography allowed basophil-inhibitory antibodies to be isolated in the eluate and appears to have eliminated basophilstimulating antibodies in the flow-through. According to a recent report [30], at least part of the basophilstimulating antibodies recovered in the flow-through of the Dactylis pollen affinity-column must be autoantiidiotypic antibodies to grass pollen-specific Igl Precisely, we have shown that the flow-through very probably contained autoanti-idiotypic antibodies, that prevented some of the specific IgE from binding to the Dactylis pollen column (Batard et al. Allergy, in press).…”

Section: Discussionmentioning

confidence: 62%

Isotypic analysis of grass pollen‐specific antibodies in human plasma. 4. Biological activity of allergen‐specific and autoanti‐IgE antibody fractions on basophil histamine release

Batard

Weyer

Laroze

et al. 1996

Clin Experimental Allergy

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Human auto‐anti‐idiotypic antibodies to mite‐specific IgE can degranulate human basophils in vitro

Abstract: These results indicate that spontaneously produced human anti-Ids can modulate the reactivity of human basophils.

Cited by 12 publications

References 28 publications

Oral tolerance induced to house dust mite extract in naive and sensitized mice: evaluation of immunoglobulin G anti‐immunoglobulin E autoantibodies and IgG–IgE complexes

Oral tolerance induced to house dust mite extract in naive and sensitized mice: evaluation of immunoglobulin G anti‐immunoglobulin E autoantibodies and IgG–IgE complexes

Anti-Ids in Allergy: Timeliness of a Classic Concept

Isotypic analysis of grass pollen‐specific antibodies in human plasma. 4. Biological activity of allergen‐specific and autoanti‐IgE antibody fractions on basophil histamine release

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