Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress

Cao, Yanjun; Fu, Yulong; Yu, Miao; Yue, Peibin; Ge, Chang‐Hui; Xu, Wenjian; Yao, Zhan; Li, Chang‐Yan; Li, Wei; Wang, Xiaohui

doi:10.1016/j.freeradbiomed.2009.07.017

Cited by 47 publications

(54 citation statements)

References 43 publications

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“…Interestingly, several reports have suggested that ALR plays a role in protection against apoptosis. Its overexpression inhibits the induction of apoptosis by H 2 O 2 in SH-SY5Y cells [14], and by radiation in HepG2 cells [15]. Recently, ALR has also been identified as a critical regulator of hematopoietic stem cells (HSC) proliferation [16].…”

Section: Germ Cell Preparation and Flow Cytometrymentioning

confidence: 99%

Mice overexpression of <i>human augmenter of liver regeneration</i> (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility

Cao

et al. 2012

Endocr J

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Section: Germ Cell Preparation and Flow Cytometrymentioning

confidence: 99%

Mice overexpression of <i>human augmenter of liver regeneration</i> (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility

Cao

et al. 2012

Endocr J

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“…8), demonstrating the antioxidative effect of HSS. Although the mechanism of free radical scavenging by HSS remains unclear, the promotion of antioxidative enzyme activity such as by glutathione peroxidase (GPx) (Cao et al, 2009) and the abundance of thiol and disulfide bonds within the HSS crystal structure may account for this process.…”

mentioning

confidence: 99%

Adenoviral Gene Transfer of Hepatic Stimulator Substance Confers Resistance Against Hepatic Ischemia–Reperfusion Injury by Improving Mitochondrial Function

Jiang

2013

Human Gene Therapy

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Hepatic stimulator substance (HSS) has been suggested to protect liver cells from various toxins. However, the precise role of HSS in hepatic ischemia-reperfusion (I/R) injury remains unknown. This study aims to elucidate whether overexpression of HSS could attenuate hepatic ischemia-reperfusion injury and its possible mechanisms. Both in vivo hepatic I/R injury in mice and in vitro hypoxia-reoxygenation (H/R) in a cell model were used to evaluate the effect of HSS protection after adenoviral gene transfer. Moreover, a possible mitochondrial mechanism of HSS protection was investigated. Efficient transfer of the HSS gene into liver inhibited hepatic I/R injury in mice, as evidenced by improvement in liver function tests, the preservation of hepatic morphology, and a reduction in hepatocyte apoptosis. HSS overexpression also inhibited H/R-induced cell death, as detected by cell viability and cell apoptosis assays. The underlying mechanism of this hepatic protection might involve the attenuation of mitochondrial dysfunction and mitochondrial-dependent cell apoptosis, as shown by the good preservation of mitochondrial ultrastructure, mitochondrial membrane potential, and the inhibition of cytochrome c leakage and caspase activity. Moreover, the suppression of H/R-induced mitochondrial ROS production and the maintenance of mitochondrial respiratory chain complex activities may participate in this mechanism. This new function of HSS expands the possibility of its application for the prevention of I/R injury, such as hepatic resection and liver transplantation in clinical practice.

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“…Full-text review eliminated one article that was an editorial and did not contain original data. Ultimately, 12 articles were included in the present review (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Study characteristics are summarized in Table I.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of included studies observe ALR to be upregulated in malignant cells. In frozen and paraffin-embedded HCC tissue, ALR expression is consistently altered when compared to normal para-tumoral tissue and/or healthy controls (10,11,13,20,21). The majority of studies suggest ALR mRNA and protein levels to be higher in HCC tissue relative to normal tissue.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

“…In vitro, ALR is consistently associated with a protective effect on cancer cell survival and ANTICANCER RESEARCH 37: 3379-3383 (2017) 3380 Silencing of ALR consistently demonstrated an antitumoral effect in HCC. Upon ALR silencing, overall growth and survival of HCC cells was inhibited, while a minimal effect was noted in normal hepatocyte cells (10,19). In a murine HCC xenograft model, silencing of ALR and treatment with anti-ALR monoclonal antibodies both similarly inhibited tumor growth (19).…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

See 1 more Smart Citation

Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review

Nguyen

Dabir

2017

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Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress

Cited by 47 publications

References 43 publications

Mice overexpression of <i>human augmenter of liver regeneration</i> (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility

Mice overexpression of <i>human augmenter of liver regeneration</i> (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility

Adenoviral Gene Transfer of Hepatic Stimulator Substance Confers Resistance Against Hepatic Ischemia–Reperfusion Injury by Improving Mitochondrial Function

Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review

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