Human Atlas of the Cardiac Fiber Architecture: Study on a Healthy Population

Lombaert, Hervé; Peyrat, Jean-Marc; Croisille, Pierre; Rapacchi, Stanislas; Fanton, Laurent; Cheriet, Foued; Clarysse, Patrick; Magnin, Isabelle E.; Delingette, Hervé; Ayache, Nicholas

doi:10.1109/tmi.2012.2192743

Cited by 192 publications

(183 citation statements)

References 43 publications

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“…In order to characterise the cardiac myocardial fibre architecture, diffusion tensor MRI (DT-MRI) is used for imaging ex vivo human hearts (Lombaert et al, 2012).…”

Section: Related Workmentioning

confidence: 99%

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

Bai

Shi

Marvao

et al. 2015

Medical Image Analysis

122

114

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“…In order to characterise the cardiac myocardial fibre architecture, diffusion tensor MRI (DT-MRI) is used for imaging ex vivo human hearts (Lombaert et al, 2012).…”

Section: Related Workmentioning

confidence: 99%

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

Bai

Shi

Marvao

et al. 2015

Medical Image Analysis

122

114

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“…Atlas-based group analysis in turn utilizes atlases as common coordinate systems for performing descriptive statistics within or between image groups. Image atlases have been used for the brain and heart in both humans 34 and animals, 35 but to the best of our knowledge, they have not yet been applied to quantitative studies of the embryonic mouse heart.…”

Section: D Vs 3d Morphological Analysismentioning

confidence: 99%

Micro-Computed Tomography for the Quantitative 3-Dimensional Assessment of the Compact Myocardium in the Mouse Embryo

Merchant

Kosaka

Yost

et al. 2016

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp ently 2 dimensional (D), whereas the heart is a 3D structure, 3D morphology could represent an additional valid source of information for ventricular non-compaction in transgenic mice. Although it is possible to use computation techniques including image registration and distortion correction to reconstruct the 3D cardiac morphology from stacked 2D sections, 26 the processes are technically demanding, laborious and time-consuming. Moreover, the 3D reconstructions still rely on 2D sections, whose destructive nature precludes their use for in vivo or in situ assessment.Non-invasive, non-destructive 3D imaging of myocardial compaction in the embryonic mouse heart is faced with two technical challenges. First, an imaging modality with the appropriate combination of tissue penetration, contrast and spatial resolution needs to be identified. The spatial resolution of magnetic resonance imaging (MRI) and computed tomography (CT) has reached microscopic scales (1 s and 10 s of he mammalian embryonic cardiac ventricles are composed of an outer layer of compact myocardium and an inner layer of trabecular myocardium. 1,2 During development, compact myocardium increases in thickness while trabeculations almost completely disappear. The persistence of a thin compact myocardium with deep intertrabecular recesses is termed ventricular non-compaction in mice, and left ventricular non-compaction (LVNC) in humans. 3-6 LVNC is a relatively common and severe genetic cardiomyopathy, 7-10 in which approximately 50% of patients show biventricular involvement. 4,11,12 Often, transgenic mice have been utilized to study LVNC. 13,14 Detailed and accurate quantification of compaction in these mice is essential to define the phenotype.Morphological analyses of the compact myocardium have been traditionally performed through histological techniques involving image analysis of cardiac sections stained with hematoxylin and eosin (H&E). Background: Ventricular non-compaction is characterized by a thin layer of compact ventricular myocardium and it is an important abnormality in the mouse heart. It is reminiscent of left ventricular non-compaction, a fairly common human congenital cardiomyopathy. Non-compaction in transgenic mice has been classically evaluated by measuring the thickness of the compact myocardium through histological techniques involving image analysis of 2-dimensional (D) sections. Given the 3D nature of the heart, the aim of this study was to determine whether a technique for the non-destructive, 3D assessment of the mouse embryonic compact myocardium could be developed.

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“…Ex vivo hearts are particularly challenging to register as they present a high variability in fixture poses due to flabby ventricular walls. The human ex vivo DTMRI dataset [20,16,15] provides good candidates to evaluate our algorithms. We use four hearts (b = 0 images of size 64 3 ) that were excluded in the construction of the human atlas [15] due to their hypertrophy and highly deformed shapes (see Fig.…”

Section: Resultsmentioning

confidence: 99%

Groupwise Spectral Log-Demons Framework for Atlas Construction

Lombaert

Grady

Pennec

et al. 2013

Medical Computer Vision. Recognition Techniques and Applications in Medical Imaging

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Abstract. We introduce a new framework to construct atlases from images with very large and complex deformations. The atlas is build in parallel with groupwise registrations by extending the symmetric Log-Demons algorithm. We describe and evaluate two forms of our framework: the Groupwise LogDemons (GL-Demons) is faster but is limited to local nonrigid deformations, and the Groupwise Spectral Log-Demons (GSL-Demons) is slower but, due to isometry-invariant representations of images, can construct atlases of organs with high shape variability. We demonstrate our framework by constructing atlases from hearts with high shape variability.

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Human Atlas of the Cardiac Fiber Architecture: Study on a Healthy Population

Cited by 192 publications

References 43 publications

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

Micro-Computed Tomography for the Quantitative 3-Dimensional Assessment of the Compact Myocardium in the Mouse Embryo

Groupwise Spectral Log-Demons Framework for Atlas Construction

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