Human aquaporins: Regulators of transcellular water flow

Day, Rebecca E.; Kitchen, Philip; Owen, D.; Bland, Charlotte E.; Marshall, Lindsay J.; Conner, Alex C.; Bill, Roslyn M.; Conner, Matthew T.

doi:10.1016/j.bbagen.2013.09.033

Cited by 247 publications

(217 citation statements)

References 160 publications

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“…It is therefore possible that similar links are also important in stickleback kidneys. For example, given that aquaporins are associated with both tubule cell volume regulation and water reabsorption (Day et al, 2014), the pattern of increased expression in high salinity (Fig. 3A) could potentially be correlated with changes in tubule structure found in our study (Fig.…”

Section: Gene Expressionmentioning

confidence: 75%

Kidney morphology and candidate gene expression shows plasticity in sticklebacks adapted to divergent osmotic environments

Hasan

DeFaveri

Kuure

et al. 2017

Journal of Experimental Biology

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Novel physiological challenges in different environments can promote the evolution of divergent phenotypes, either through plastic or genetic changes. Environmental salinity serves as a key barrier to the distribution of nearly all aquatic organisms, and species diversification is likely to be enabled by adaptation to alternative osmotic environments. The threespine stickleback (Gasterosteus aculeatus) is a euryhaline species with populations found both in marine and freshwater environments. It has evolved both highly plastic and locally adapted phenotypes due to salinity-derived selection, but the physiological and genetic basis of adaptation to salinity is not fully understood. We integrated comparative cellular morphology of the kidney, a key organ for osmoregulation, and candidate gene expression to explore the underpinnings of evolved variation in osmotic plasticity within two populations of sticklebacks from distinct salinity zones in the Baltic Sea: the high salinity Kattegat, representative of the ancestral marine habitat; and the low salinity Bay of Bothnia. A common-garden experiment revealed that kidney morphology in the ancestral high-salinity population had a highly plastic response to salinity conditions whereas this plastic response was reduced in the low-salinity population. Candidate gene expression in kidney tissue revealed a similar pattern of populationspecific differences, with a higher degree of plasticity in the native high-salinity population. Together these results suggest that renal cellular morphology has become canalized to low salinity, and that these structural differences may have functional implications for osmoregulation.

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Section: Gene Expressionmentioning

confidence: 75%

Kidney morphology and candidate gene expression shows plasticity in sticklebacks adapted to divergent osmotic environments

Hasan

DeFaveri

Kuure

et al. 2017

Journal of Experimental Biology

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“…Regulatory cell volume decrease (RVD) is mediated by potassium chloride and taurine efflux and regulatory cell volume increase (RVI) by sodium influx [154]. AQPs play a role in mediating the osmotic water movement in cell volume regulation [155], but there is some evidence that their role may go beyond acting as a passive water pore.…”

Section: Cell Volume Regulation By Aqpsmentioning

confidence: 99%

“…AQP4 is a water-selective AQP primarily expressed in glial cells (astrocytes and retinal Müller cells) of the central nervous system and the basolateral membranes of kidney collecting duct cells [155]. AQP4 exists in two major isoforms (although there is emerging evidence of further isoforms [184]).…”

Section: Aqp4mentioning

confidence: 99%

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

Kitchen

Day

Salman

et al. 2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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128

115

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BACKGROUND: Aquaporin (AQP) water channels are best known as passive transporters of water that are vital for water homeostasis. SCOPE OF REVIEW:AQP knockout studies in whole animals and cultured cells, along with naturally occurring human mutations suggest that the transport of neutral solutes through AQPs has important physiological roles. Emerging biophysical evidence suggests that AQPs may also facilitate gas (CO2) and cation transport. AQPs may be involved in cell signalling for volume regulation and controlling the subcellular localization of other proteins by forming macromolecular complexes. This review examines the evidence for these diverse functions of AQPs as well their physiological relevance. MAJOR CONCLUSIONS:As well as being crucial for water homeostasis, AQPs are involved in physiologically important transport of molecules other than water, regulation of surface expression of other membrane proteins, cell adhesion, and signalling in cell volume regulation. GENERAL SIGNIFICANCE:Elucidating the full range of functional roles of AQPs beyond the passive conduction of water will improve our understanding of mammalian physiology in health and disease. The functional variety of AQPs makes them an exciting drug target and could provide routes to a range of novel therapies.3

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“…30 AQPs are crucial for the regulation of cell volume, playing a role in mediating osmotic water flow, 31 and recent research has provided further evidence for a general mechanism for cell volume regulation by which AQPs may function as a component of a sensing complex required to activate RVD/RVI.…”

Section: Aqps and Cell Volumementioning

confidence: 99%

Role of aquaporins in cell proliferation: What else beyond water permeability?

2016

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In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement of these proteins in numerous cellular processes seemingly unrelated, at least some of them in a direct way, to their canonical function of water permeation. Here, we have presented a broad range of evidence demonstrating that these proteins have a role in cell proliferation by various different mechanisms, namely, by allowing fast cell volume regulation during cell division; by affecting progression of cell cycle and helping maintain the balance between proliferation and apoptosis, and by crosstalk with other cell membrane proteins or transcription factors that, in turn, modulate progression of the cell cycle or regulate biosynthesis pathways of cell structural components. In the end, however, after discussing all these data that strongly support a role for AQPs in the cell proliferation process, it remains impossible to conclude that all these other functions attributed to AQPs occur completely independently of their water permeability, and there is a need for new experiments designed specifically to address this interesting issue.

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Human aquaporins: Regulators of transcellular water flow

Cited by 247 publications

References 160 publications

Kidney morphology and candidate gene expression shows plasticity in sticklebacks adapted to divergent osmotic environments

Kidney morphology and candidate gene expression shows plasticity in sticklebacks adapted to divergent osmotic environments

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

Role of aquaporins in cell proliferation: What else beyond water permeability?

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