Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients

Savaş, Sumru; Tayfur, Eda; Saraç, Fulden; Akbaş, Sibel; Acarer, Ahmet; Gündüz, Cumhur; Akkuş, Dilek; Akçiçek, Fehmi

doi:10.1007/s13410-020-00832-5

Int J Diabetes Dev Ctries

2020

DOI: 10.1007/s13410-020-00832-5

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Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients

Sumru Savaş

Eda Tayfur

Fulden Saraç

et al.

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2024

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Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

Varma,

Luo,

Bostrom

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONVervets are non‐human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics.METHODSAmyloid immunoreactivity in the frontal cortex and temporal cortex/hippocampal regions from archived vervet brain samples ranging from young adulthood to old age was quantified. We also obtained cognitive scores, plasma samples, and cerebrospinal fluid (CSF) samples in additional animals. Plasma and CSF proteins were quantified with platforms utilizing human antibodies.RESULTSWe found age‐related increases in Aβ deposition in both brain regions. Bioinformatic analyses assessed associations between biomarkers and age, sex, cognition, and CSF Aβ levels, revealing changes in proteins related to immune‐related inflammation, metabolism, and cellular processes.DISCUSSIONVervets are an effective model of aging and early‐stage Alzheimer's disease, and we provide translational biomarker data that both align with previous results in humans and provide a basis for future investigations.Highlights We found changes in immune and metabolic plasma biomarkers associated with age and cognition. Cerebrospinal fluid (CSF) biomarkers revealed changes in cell signaling indicative of adaptative processes. TNFRSF19 (TROY) and Artemin co‐localize with Alzheimer's disease pathology. Vervets are a relevant model for translational studies of early‐stage Alzheimer's disease.

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Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

Varma,

Luo,

Bostrom

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

show abstract

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Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients

Cited by 1 publication

References 43 publications

Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

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