Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3
Patricia Huebbe,
Stephanie Bilke,
Johanna Rueter
et al.
Abstract:Recent genome- and exome-wide association studies suggest that the human
APOE ε4
allele protects against non-alcoholic fatty liver disease (NAFLD), while
ε3
promotes hepatic steatosis and steatohepatitis. The present study aimed at examining the
APOE
genotype-dependent development of fatty liver disease and its underlying mechanisms in a targeted replacement mouse model. Male mice expressing the human APOE3 or APOE4 protein isoforms on a C57B… Show more
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