Human apoCIII transgenic mice with epicardial adipose tissue inflammation and PRESERVATION of the cardiac plexus

Jimenes, Diogo Rodrigues; Teixeira, Nilton Rodrigues; Pereira, Andréia Vieira; Berti, Jairo Augusto; Barbosa, Carmem Patrícia; Sant’Ana, Débora de Mello Gonçales

doi:10.1016/j.exger.2021.111261

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Although there were no body weight differences among the experimental groups, the relative mass of adipose tissue in relation to body weight was higher in the CIII animals. The increase in relative fat mass was accompanied by the presence of larger adipocytes, which is consistent with previous data in this animal model obtained from epicardial adipose tissue ( 24 ), and MICT reduced adipocyte area. Our data is in agreement with previous studies observing that this type of physical exercise leads to adipose tissue remodeling, reducing adipocyte size without necessarily causing weight loss ( 25 ).…”

Section: Discussionsupporting

confidence: 92%

Moderate-intensity continuous training reduces triglyceridemia and improves oxygen consumption in dyslipidemic apoCIII transgenic mice

Teixeira Junior,

Jimenes,

Schultz

et al. 2024

Braz J Med Biol Res

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This study aimed to investigate metabolism modulation and dyslipidemia in genetic dyslipidemic mice through physical exercise. Thirty-four male C57Bl/6 mice aged 15 months were divided into non-transgenic (NTG) and transgenic overexpressing apoCIII (CIII) groups. After treadmill adaptation, the trained groups (NTG Ex and CIII Ex) underwent an effort test to determine running performance and assess oxygen consumption (V̇O 2 ), before and after the training protocol. The exercised groups went through an 8-week moderate-intensity continuous training (MICT) program, consisting of 40 min of treadmill running at 60% of the peak velocity achieved in the test, three times per week. At the end of the training, animals were euthanized, and tissue samples were collected for ex vivo analysis. ApoCIII overexpression led to hypertriglyceridemia (P<0.0001) and higher concentrations of total plasma cholesterol (P<0.05), low-density lipoprotein (LDL) cholesterol (P<0.01), and very low-density lipoprotein (VLDL) cholesterol (P<0.0001) in the animals. Furthermore, the transgenic mice exhibited increased adipose mass (P<0.05) and higher V̇O 2peak compared to their NTG controls (P<0.0001). Following the exercise protocol, MICT decreased triglyceridemia and cholesterol levels in dyslipidemic animals (P<0.05), and reduced adipocyte size (P<0.05), increased muscular glycogen (P<0.001), and improved V̇O 2 in all trained animals (P<0.0001). These findings contribute to our understanding of the effects of moderate and continuous exercise training, a feasible non-pharmacological intervention, on the metabolic profile of genetically dyslipidemic subjects.

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Section: Discussionsupporting

confidence: 92%

Moderate-intensity continuous training reduces triglyceridemia and improves oxygen consumption in dyslipidemic apoCIII transgenic mice

Teixeira Junior,

Jimenes,

Schultz

et al. 2024

Braz J Med Biol Res

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“…The efficient physical exercise in avoiding the gain of body grease can occur as a consequence of increasing of the lipolysis and β-oxidation of fatty acids, making the organism to use the fat stocks as energetic substrate, mainly in the muscular cells. Furthermore, studies show that after the practice of physical exercises, it is induced the increasing of lipolysis in the adipocytes 9,10 .…”

Section: Methodsmentioning

confidence: 99%

High Intensity Interval Training Does Not Change the Area in the Adipocytes of the Epicardium of Fat Rats

Cândido¹,

Vale²,

Jimenes³

et al. 2023

arqmudi

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The obesity due to high caloric ingestion is related to the accumulation of body fat andpredisposes cardiovascular diseases. Recent studies about the High Intensity Interval Training(HIIT) evidence benefits of its practice in patients that maybe carrying this disease, mainlybecause of the reduction of comorbidities associated with obesity. This present study has theobjective of evaluating the HIIT effects on the adipocytes’ changes of the epicardium adiposetissue in fat animals induced by the consumption of high-fat diet. It was used male rats ofWistar lineage fed daily with HFD and trained by HIIT three times a week for 8 consecutiveweeks. The animals were weighted during the training sections and, after its euthanasia, wererealized histological analyses of the epicardium adipose tissue. The results showed that HFDincreased the body weight of the animals and the side view of the adipocytes. However, theHIIT did not change the area of the adipocytes of the epicardial adipose tissue, even thoughthe diet had been a hypertrophy factor of this tissue. Then, we can conclude that HIITcontributes to avoid the body weight gain but was not capable of reducing the area of theadipocytes of the epicardium adipose tissue.

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Human apoCIII transgenic mice with epicardial adipose tissue inflammation and PRESERVATION of the cardiac plexus

Cited by 2 publications

References 36 publications

Moderate-intensity continuous training reduces triglyceridemia and improves oxygen consumption in dyslipidemic apoCIII transgenic mice

Moderate-intensity continuous training reduces triglyceridemia and improves oxygen consumption in dyslipidemic apoCIII transgenic mice

High Intensity Interval Training Does Not Change the Area in the Adipocytes of the Epicardium of Fat Rats

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