Human antigen R affects the migration and invasion of human lung cancer A549 cells and regulates E-cadherin suppressor Snail

Shan, Shufang; Bao, Qixue; Ma, Guochen; Yao, Yuqin; Xiong, Jingyuan; You, Jing

doi:10.14715/cmb/2022.68.6.2

Cited by 6 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Snail inhibits the gene expression of E-cadherin, acting as an upstream molecule. In investigations of tumor invasion, researchers commonly view Ecadherin and Snail as a cohesive unit due to their vital involvement in tumor growth [26,27]. E-cadherin and Snail are frequently studied in relation to tumor developmentIn AM research [28], high levels of Ecadherin and Snail proteins have also been detected.…”

Section: Discussionmentioning

confidence: 99%

Notch signaling pathway promotes invasion of ameloblastoma by regulating E-cadherin via cyclinD1

Gabiyatu,

Li,

Amuersana

et al. 2023

Preprint

View full text Add to dashboard Cite

This study aims to investigate the impact of the Notch signaling pathway on the invasion of Ameloblastoma (AM) and its influence on the expression of cyclinD1 protein. AM cells and dental follicle (DF) cells were cultured in vitro. The proliferation activity of two cells were measured using the CCK8. The invasive ability of cells were assessed using the Transwell chamber. A comparison was made between the proliferation and invasion abilities of two cells. The protein expression of cyclinD1, E-cadherin, and Snail was detected using Western Blot. The Notch signaling pathway was blocked using the Notch inhibitor FLI-06.The comparison of proliferation and invasion abilities between two cells were higher than control group cells.The difference was statistically significant (P＜0.05). The Notch inhibitor on the invasive ability of AM cells is significantly lower than control group. The difference was statistically significant (P＜0.05). After intervention with FLI-06, the protein expression of CDK 1, cyclinD1, and Snail in AM cells showed a significant downregulation, while the protein expression of E-cadherin showed a significant upregulation.The Notch signaling pathway plays a crucial role Notch signaling pathway promotes invasion ofAM by regulating E-cadherin via cyclinD1.

show abstract

Section: Discussionmentioning

confidence: 99%

Notch signaling pathway promotes invasion of ameloblastoma by regulating E-cadherin via cyclinD1

Gabiyatu,

Li,

Amuersana

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Typically, NSCLC has been identified and classified into three different categories: large-cell cancer, adenocarcinoma, and squamous cell carcinoma (3). Although many strategies have been developed to treat NSCLC, including surgery, chemotherapy, radiotherapy and immunotherapy like PD-1/PD-L1 antibodies, the death rate from NSCLC remains high, and the major cause is that the tumor has metastasized before diagnosis (4). Therefore, further elucidation of the mechanisms of NSCLC progression and metastasis and as well as identification of new potential targets for intervention are critical for the treatment of this cancer.…”

Section: Introductionmentioning

confidence: 99%

KIFC1 aggravates non-small-cell lung cancer cell proliferation and metastasis via provoking TGF-β/SMAD signal

Yafang Liu,

Wei Ye,

Xiaohui Miao

et al. 2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p

et al. 2023

View full text Add to dashboard Cite

Human antigen R affects the migration and invasion of human lung cancer A549 cells and regulates E-cadherin suppressor Snail

Cited by 6 publications

References 41 publications

Notch signaling pathway promotes invasion of ameloblastoma by regulating E-cadherin via cyclinD1

Notch signaling pathway promotes invasion of ameloblastoma by regulating E-cadherin via cyclinD1

KIFC1 aggravates non-small-cell lung cancer cell proliferation and metastasis via provoking TGF-β/SMAD signal

Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p

Contact Info

Product

Resources

About