2005
DOI: 10.1128/iai.73.8.4607-4613.2005
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Human Antibody against Shiga Toxin 2 Administered to Piglets after the Onset of Diarrhea Due to Escherichia coli O157:H7 Prevents Fatal Systemic Complications

Abstract: Infection of children with Shiga toxin (Stx)-producing Escherichia coli (STEC) can lead to hemolytic-uremic syndrome (HUS) in 5 to 10% of patients. Stx2, one of two toxins liberated by the bacterium, is directly linked with HUS. We have previously shown that Stx-specific human monoclonal antibodies protect STEC-infected animals from fatal systemic complications. The present study defines the protective antibody dose in relation to the time of treatment after the onset of diarrhea in infected gnotobiotic piglet… Show more

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Cited by 75 publications
(100 citation statements)
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“…In addition, we observed that the OIA method was more sensitive than the EIA (14). In addition, therapies such as humanized monoclonal antibodies that can be passively administered to protect against Shiga toxins are in development (5,13). Once these therapies are available, at-risk patients who have been identified by rapid toxin detection methods can be treated promptly, since the efficacy of such interventions is likely to be proportional to the speed with which therapy is administered.…”
Section: Discussionmentioning
confidence: 96%
“…In addition, we observed that the OIA method was more sensitive than the EIA (14). In addition, therapies such as humanized monoclonal antibodies that can be passively administered to protect against Shiga toxins are in development (5,13). Once these therapies are available, at-risk patients who have been identified by rapid toxin detection methods can be treated promptly, since the efficacy of such interventions is likely to be proportional to the speed with which therapy is administered.…”
Section: Discussionmentioning
confidence: 96%
“…In this contribution different approaches have aimed to neutralize Stx by the use of pharmacological compounds (26), specific antibodies (27,28), or recombinant bacteria expressing globotriaosylceramide-3 (29). Herein, we present NO, a critical mediator of the host mucosal innate immune response, as a potent inhibitor of Stx2 synthesis by EHEC.…”
Section: Discussionmentioning
confidence: 99%
“…Research in this field is still ongoing, but to date, the results have been disappointing [111] . Another option for the future is to treat patients during the diarrheal phase with monoclonal antibodies against Shiga toxin [112] . In December 2005, the United States Food and Drug Administration (FDA) approved orphan drug status for 2 chimerical anti-Stx antibodies.…”
Section: Peculiar Consideration For Treatment Of Hus D+mentioning
confidence: 99%