Human Anti-Chickenpox Immunoglobulin in the Prevention of Chickenpox

Evans, Eric; Pollock, T.M.; Cradock-Watson, J. E.; Ridehalgh, Margaret K. S.

doi:10.1016/s0140-6736(80)90897-1

Cited by 51 publications

(21 citation statements)

References 3 publications

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“…49 It should be considered for individuals who fulfil all three of the criteria listed in Table 3. 50 VZIG may be offered up to 10 days after exposure, but is ideally administered within 7 days of contact with an infective case of chickenpox or exposed shingles.…”

Section: Prevention Of Chickenpox Following Exposurementioning

confidence: 99%

Chickenpox in adults – Clinical management

Tunbridge

Breuer²,

Jeffery

2008

Journal of Infection

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Section: Prevention Of Chickenpox Following Exposurementioning

confidence: 99%

Chickenpox in adults – Clinical management

Tunbridge

Breuer²,

Jeffery

2008

Journal of Infection

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“…The duration of protection that is provided after VZIG administration is unknown but is likely to broadly equate to the half-life of other immunoglobulins of 3-4 weeks [49]. Approximately half of susceptible household contacts will develop chickenpox despite receiving VZIG [50]. This group will generally have attenuated disease but should still be considered for antiviral therapy if a chickenpox like illness develops.…”

Section: Management Of Varicella Exposurementioning

confidence: 99%

Managing varicella zoster virus contact and infection in patients on anti-rheumatic therapy

et al. 2017

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Chickenpox and shingles can be more severe and occasionally life threatening in immunosuppressed patients. As such, some groups warrant a more detailed history, serological testing and consideration of prophylaxis following contact with the virus. Active disease may also require more aggressive treatment with antivirals. Guidance for the use of Varicella Zoster Immunoglobulin (VZIG) has recently been updated by Public Health England with important implications for rheumatology patients.

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“…VZIG has been shown to modify varicella infections resulting in milder disease, sometimes preventing infections altogether 7–9. The evidence suggests that the effect of VZIG is maximised by giving it within 72 h of exposure 10.…”

Section: Varicella Zoster Immunoglobulinmentioning

confidence: 99%

“…Roughly 15% of those given VZIG who do not develop symptoms of chickenpox will have had a subclinical infection and seroconversion 8. Therefore, it is advisable that patients should be retested for VZ antibody if subsequent re-exposure occurs.…”

Section: Varicella Zoster Immunoglobulinmentioning

confidence: 99%