Human and murine hematopoietic stem cell aging is associated with functional impairments and intrinsic megakaryocytic/erythroid bias

Nilsson, Arne A.; Soneji, Shamit; Adolfsson, Sofia; Bryder, David; Pronk, Cornelis Jan

doi:10.1016/j.exphem.2016.06.205

Cited by 4 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aged mice display elevated platelet counts [1][2][3] and myeloid cells [4], with concomitant decreased red blood cells (RBC) [1,3] and haemoglobin (Hb) [1,3]. In aged BM, there is an increase in the frequency of committed megakaryocyte progenitors (MkPs) [1,2,5,6] and granulocyte-monocyte progenitor (GMP) [2,6] and a decline in the frequency of common lymphoid progenitor (CLP) [6,7] and colony forming unit-erythroid (CFU-E) [2,6]. Elderly humans frequently suffer from anemia, with a~25% prevalence of anemia found in people over 85 years [8].…”

Section: Age-associated Changes In Hscs 1the Functioning Of Hematopoietic Stem Cells Declines With Agementioning

confidence: 99%

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Yang

Haan

2021

Cells

View full text Add to dashboard Cite

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.

show abstract

Section: Age-associated Changes In Hscs 1the Functioning Of Hematopoietic Stem Cells Declines With Agementioning

confidence: 99%

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Yang

Haan

2021

Cells

View full text Add to dashboard Cite

show abstract

“…Bias tersebut juga disebabkan karena penuaan menyebabkan peningkatan ekspresi gen spesifik mieloid dan sebaliknya, penurunan ekspresi gen spesifik limfoid. 37 Diketahui juga baru-baru ini bahwa diagnosis gangguan mieloproliferatif tidak hanya meningkatkan kerentanan terhadap COVID-19, tetapi juga memperburuk klinis dan meningkatkan risiko kematian. 38 Makrofag alveolar sebagai APC utama pada paru-paru mengalami penurunan fungsi seiring dengan bertambahnya usia, terutama fungsinya untuk fagositosis dan menghambat kerusakan paru akibat infeksi virus.…”

Section: Imunopatogenesis Covid-19unclassified

Immunosenescence and the Susceptibility of the Elderly to Coronavirus Disease 2019 (COVID-19)

2020

View full text Add to dashboard Cite

A new disease caused by a newly-found coronavirus, known as Coronavirus Disease 2019 (COVID-19), has been declared as a pandemic by World Health Organization (WHO). This new disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak started in late December of 2019 and it did not take a long time until it spread to more than 200 countries in the world with over 4 million confirmed cases to date. The number keeps skyrocketing as day passes, followed by the increasing number of fatalities. Among all of the infected patients, elderly is one of the vulnerable populations. Studies reported that the risk of infection is doubled in older people. This infection-susceptible characteristic may be due to the weak immune system, therefore they lack the capabilities to fight the infection. The deterioration of immune system in elderly is known as immunosenescence. The aim of this literature review is to understand the effect of immunosenescence in the immunopathogenesis and susceptibility of elderly who are exposed to COVID-19 infection. (J Respir Indo. 2020; 40(3): 182-91)

show abstract

“…They interact with thymic endothelial cells, allowing their differentiation into early thymic progenitors ( 12 , 13 ). With age, both murine and human hematopoietic stem cells are biased towards the production of non-lymphoid cells ( 14 , 15 ) contributing to a decrease in circulating TSP populations ( 16 ). Furthermore, the intrinsic ability of TSPs to differentiate toward T-cell lineage decreases with time ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation

Gaudeaux

Moirangthem

Bauquet³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of preference for numerous malignant and non-malignant hemopathies. The outcome of this approach is significantly hampered by not only graft-versus-host disease (GvHD), but also infections and relapses that may occur because of persistent T-cell immunodeficiency following transplantation. Reconstitution of a functional T-cell repertoire can take more than 1 year. Thus, the major challenge in the management of allogeneic HSCT relies on the possibility of shortening the window of immune deficiency through the acceleration of T-cell recovery, with diverse, self-tolerant, and naïve T cells resulting from de novo thymopoiesis from the donor cells. In this context, adoptive transfer of cell populations that can give rise to mature T cells faster than HSCs while maintaining a safety profile compatible with clinical use is of major interest. In this review, we summarize current advances in the characterization of thymus seeding progenitors, and their ex vivo generated counterparts, T-cell progenitors. Transplantation of the latter has been identified as a worthwhile approach to shorten the period of immune deficiency in patients following allogeneic HSCT, and to fulfill the clinical objective of reducing morbimortality due to infections and relapses. We further discuss current opportunities for T-cell progenitor-based therapy manufacturing, including iPSC cell sources and off-the-shelf strategies. These opportunities will be analyzed in the light of results from ongoing clinical studies involving T-cell progenitors.

show abstract

Human and murine hematopoietic stem cell aging is associated with functional impairments and intrinsic megakaryocytic/erythroid bias

Cited by 4 publications

References 48 publications

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Immunosenescence and the Susceptibility of the Elderly to Coronavirus Disease 2019 (COVID-19)

T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation

Contact Info

Product

Resources

About