Human and Mammalian Cytogenetics

Hsu, T. C.

doi:10.1007/978-1-4612-6159-9

Cited by 101 publications

(28 citation statements)

References 105 publications

(121 reference statements)

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“…Our findings were quickly confirmed in several other laboratories (8), and at the First International Conference on Nomenclature in 1960, it was decided to name abnormal chromosomes in human tumors after the city of discovery, hence the name "Philadelphia chromosome" (9). …”

Section: Cytogenetics and Molecular Genetics Of CMLsupporting

confidence: 63%

Progress with Chronic Myelogenous Leukemia: A Personal Perspective over Four Decades

Nowell̀

2002

Annu. Rev. Med.

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s Abstract Our understanding and treatment of chronic myelogenous leukemia (CML) has progressed since 1960 in parallel with work on cancer in general. CML provided the first evidence of a specific genetic change associated with a human cancer (the Philadelphia chromosome) and the clonal nature of these disorders. With improved cytogenetic and molecular techniques over subsequent decades, the specific genetic rearrangements of CML and many other tumors were defined and the complex mechanisms of carcinogenesis gradually unraveled. During this period, improved treatments for CML (chemotherapy, interferon, bone marrow transplantation) were implemented, and therapy targeted to the specific genetic change in the leukemic cells has recently been brought to promising clinical trials. Similar efforts are under way for other human cancers, and although the problem is enormously complex, there is real hope for major improvements in controlling these disorders.

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Section: Cytogenetics and Molecular Genetics Of CMLsupporting

confidence: 63%

Progress with Chronic Myelogenous Leukemia: A Personal Perspective over Four Decades

Nowell̀

2002

Annu. Rev. Med.

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“…This Wilming, et al [18] is information obtained from 2008 to 2011 and the structures of genes are presented in Table 2. An abnormal number of chromosomes, euploidy, may be lethal [19]; [20]; [21]; [22] some chromosome alterations in this study are seen in table 1 and Figure 1. Genetic counseling can be provided in multidisciplinary form with the necessary knowledge, which is important for families carrying this type of chromosome rearrangements, including patients with taurodontism.…”

Section: Discussiónmentioning

confidence: 87%

The Importance of Clinical Genotype in Patients with Klinefelter Syndrome. A Genetic Disorder Asociated to Taurodontism

Castilla¹,

Hernandez²,

Rodríguez

2015

Journal of Diseases

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Taurodontism is a clinical condition found in the molar teeth of humans whereby the body of the tooth and pulp chamber is enlarged vertically at the expense of the roots. As a result Journal of Diseases 2015 Vol.2, No.2, pp.12-22 ISSN(e): 2410 Contribution/ OriginalityThis study contributes in the existing literature the relation of a well known genetic syndrome as klinefelter, a sexual chromosome alteration (47, XXY) and pediatric patients with taurodontism, an oral situation with teeth roots that grow crookedly with very huge teeth, likened to a bull.

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“…For example, they all share the same diploid chromosome number (2n 74; Hsu & Benirschke 1969), they are all induced ovulators (San-Martin et al 1968;Musa & Abusineima 1978;El Wishy 1987) and they all have a bicornuate uterus in which the left horn is considerably larger than the right and always acts as the site of implantationö although ovulation occurs equally frequently from the left and right ovaries (Arthur et al 1985;El Wishy 1988). They also share the same di¡use, non-invasive epitheleochorial placenta (Van Lennep 1963;Steven et al 1980;Skidmore et al 1996a).…”

Section: Introductionmentioning

confidence: 99%

Hybridizing Old and New World camelids: Camelus dromedarius x Lama guanicoe

Skidmore¹,

Billah²,

Binns

et al. 1999

Proc. R. Soc. Lond. B

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Thirty female dromedary camels were inseminated on a total of 50 occasions with 2^4 ml of fresh guanaco semen diluted with an equal volume of commercially available camel semen extender. Similarly, nine female guanacos were inseminated on 34 occasions with 4^6 ml of fresh, diluted camel semen. Only two of the dromedary females conceived; one aborted a female foetus on day 260 of gestation and the other gave birth to a stillborn female calf on day 365. Six conceptions occurred in the female guanacos. Two of these conceptuses, diagnosed by ultrasound, were resorbed between days 25 and 40 of gestation, one female foetus was aborted on day 291, another female foetus was aborted on day 302, and one female calf was stillborn on day 365 of gestation. The sixth foetus, a male, was born prematurely but alive after a 328-day gestation. It had a phenotypic appearance intermediate between that of a camel and a guanaco and its hybrid parentage was con¢rmed by the DNA ¢ngerprinting of eight llama microsatellites. To our knowledge, this is the ¢rst viable hybrid ever to be produced between Old World and New World camelids, which have been reproductively isolated from one another for at least 11 million years. The preponderance of female hybrids is in accordance with Haldane's law. Histological examination of their ovaries revealed a failure of meiosis, with only an occasional abnormal oocyte surrounded by follicle cells. Although the diploid chromosone number of camels and guanacos is the same (2n 74), su¤cient genetic change has taken place to make the pairing of homologous chromosomes no longer possible.

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Human and Mammalian Cytogenetics

Cited by 101 publications

References 105 publications

Progress with Chronic Myelogenous Leukemia: A Personal Perspective over Four Decades

Progress with Chronic Myelogenous Leukemia: A Personal Perspective over Four Decades

The Importance of Clinical Genotype in Patients with Klinefelter Syndrome. A Genetic Disorder Asociated to Taurodontism

Hybridizing Old and New World camelids: Camelus dromedarius x Lama guanicoe

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