Human Amnion Epithelial Cell Transplantation Abrogates Lung Fibrosis and Augments Repair

Abstract

hAECs offer promise as a cellular therapy for alveolar restitution and to reduce lung inflammation and fibrosis.

Therapeutic Effect of Human Amniotic Membrane–Derived Cells on Experimental Arthritis and Other Inflammatory Disorders

“…This could be due to the previously described epithelial-to-mesenchymal cell transition that amniotic epithelial cells undergo after various passages in culture (37). Both in vitro and in vivo studies have demonstrated that cells from either the epithelial or mesenchymal layers exert immunomodulatory properties and ameliorate disease with inflammatory bases, including lung and liver fibrosis and EAE (15,19,(38)(39)(40)(41). Interestingly, an important percentage of the HAMCs used in our study expressed CD106 (vascular cell adhesion molecule 1), which identifies a subpopulation of mesenchymal stem cells with unique immunoregulatory properties in various tissues, especially in the placenta (42).…”

Effects of inhalation and intravenous administration of allogeneic mesenchymal bone marrow stromal cells in a bleomycin-induced model of pulmonary fibrosis in rabbits

“…Трансплантация легких у таких больных проводится редко -с одной стороны, в силу сравни-тельно невысокой выживаемости после операции, а с другой -в связи с поздним началом заболевания (большинство больных старше 60 лет). Одним из перспективных подходов к лечению фиброзных за-болеваний легких рассматривается трансплантация различных видов стволовых клеток (чаще мезенхи-мальных), которые за счет паракринных эффектов способны предотвратить или замедлить развитие фиброза в экспериментальных моделях [2][3][4].…”

Stem cell therapy for idiopathic pulmonary fibrosis: How far are we from the bench to the bedside?

“…These capabilities are assumed as their mechanisms which reverse experimental pulmonary fibrosis in animals [52]. The anti-inflammatory and anti-fibrotic capabilities are also presented in amnion epithelial cells, placenta-derived cells, umbilical cord mesenchymal stem cells and adiposederived stem cells (ADSCs) [53][54][55][56][57][58][59]. Interestingly, ESC engraftment also ameliorates experimental pulmonary fibrosis, although clinical research using ESCs is forbidden at the current time [60,61].…”