Human Alkhumra hemorrhagic Fever: Emergence, history and epidemiological and clinical profiles

Hershan, Almonther; Karunamoorthi, Kaliyaperumal; Al-Mekhlafi, Hesham M.

doi:10.1016/j.sjbs.2021.10.031

Cited by 8 publications

(2 citation statements)

References 56 publications

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“…The molecular characterization of AHFV has been done by many research groups. Like other Flaviviruses, AHFV genome size ranges from 10.5 to 10.7 kb and codes a polyprotein which cleaves into structural and non-structural proteins (Coat, Pre-Membrane and Envelop-Structural proteins) and non-structural protein known as NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 by viral and host proteases [1,9,10,12,18,19,24,26,29]. The 5' and 3' untranslated regions (UTRs), of the viral genome consist the coding sequence responsible for viral pathogenicity.…”

Section: Molecular Characterizationmentioning

confidence: 99%

“…The clinical manifestations range from mild to severe and includes fever, headache, retro-orbital pain, arthralgia, myalgia, anorexia, vomiting, leukopenia, thrombocytopenia, and elevated liver enzymes, creatine kinase, and lactate dehydrogenase. Additionally, gastroenteritis-like illness, rhabdomyolysis, severe muscle weakness and as well as severe neurologic and hemorrhagic symptoms have also been reported [1,22,28]. The mortality rate of AHFV infection ranged from 20-30% in Jeddah and Makkah [11,30].…”

Section: Clinical Features Mortality Of Ahfv Infection and Manifestat...mentioning

confidence: 99%

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Alkhumra Hemorrhagic Fever Virus (AHFV): Current Status and Future Prospects

Azhar

2023

Postępy Mikrobiologii - Advancements of Microbiology

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The objective of this review to summarize the current status of information about the Alkhumra hemorrhagic fever caused by Alkhumra hemorrhagic fever virus an Arboviral infection. This virus was identified in Alkhumra district of Jeddah, Saudi Arabia in 1995 from a butcher patient. The infected individual develops symptoms febrile flu-like illness, hemorrhagic manifestations and less like encephalitis. Several cases have been reported from various locations of Saudi Arabia and a few from Egypt and is further expanding in tropical and subtropical regions of Western Asia. The virus is transmitted to human by direct contact to animal, raw meat, and biproducts as well as either tick or mosquito bites. Based on the recent status, a great concern of public health was raised with the AHFV epidemics and infection. Currently, there is no effective vaccine and antiviral therapeutics against AHFV. So, there is an urgent need to design and develop an effective preventive measure using interdisciplinary approach. This review will provide the status of research work based on the latest published information about AHFV. The provided information will be highly useful to design the effective preventive measures to control the disease in the Kingdom of Saudi Arabia.

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