Human airway epithelial cell pH regulatory proteins in cystic fibrosis: Differential expression in nasal and bronchial airway cells
Michael D Davis,
Benjamin Gaston,
Laura Smith
et al.
Abstract:Background. Decreased apical bicarbonate transport into the airway surface liquid (ASL) has been associated with decreased ASL pH in some studies. Low ASL pH can have adverse respiratory effects. However, the human CF epithelium can also normalize ASL pH. We hypothesized that pH regulatory proteins other than the CF transmembrane regulator (CFTR) would be upregulated in the CF epithelium.
Methods. We grew primary human nasal and bronchial epithelial cells from healthy controls and CF subjects at air-liquid in… Show more
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