Human African Trypanosomiasis

Bottieau, Emmanuel; Clerinx, Jan

doi:10.1016/j.idc.2018.10.003

Cited by 45 publications

(13 citation statements)

References 75 publications

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“…These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity.The mostactiveadduct with the best selectivity in this study wasfound to be the phenylacetoxy hydrazone 1b Vector-borne kinetoplastid diseases, such as Chagas disease (CD), [1] leishmaniasis, and human African trypanosomiasis (HAT), [2] threaten almost ab illion people worldwide. These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity.The mostactiveadduct with the best selectivity in this study wasfound to be the phenylacetoxy hydrazone 1b Vector-borne kinetoplastid diseases, such as Chagas disease (CD), [1] leishmaniasis, and human African trypanosomiasis (HAT), [2] threaten almost ab illion people worldwide.…”

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confidence: 86%

“…Vector-borne kinetoplastid diseases, such as Chagas disease (CD), [1] leishmaniasis, and human African trypanosomiasis (HAT), [2] threaten almost ab illion people worldwide. [3] The availabled rugs against these neglected tropical diseases (NTDs) are characterizedb yt oxicity, limited efficacy,a nd increasingr esistance.…”

Section: In Memory Of Professor Georgebf Oscolosmentioning

confidence: 99%

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Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity

et al. 2019

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The synthesis and pharmacological evaluation of C1‐substituted adamantane hydrazones, their C2‐substituted isomers, and C1‐substituted adamantane furanoic carboxamides is described. These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity. The most active adduct with the best selectivity in this study was found to be the phenylacetoxy hydrazone 1 b (2‐[4‐(tricyclo[3.3.1.13,7]dec‐1‐yl)phenyl]‐N′‐[(5‐nitrofuran‐2‐yl)methylene]acetohydrazide; EC50=11±0.9 nm, SITb=770).

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confidence: 86%

Section: In Memory Of Professor Georgebf Oscolosmentioning

confidence: 99%

Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity

et al. 2019

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“…Human African trypanosomiasis (HAT), also known as sleeping sickness, is transmitted by the tsetse fly (Diptera: genus Glossina) and is found exclusively in intertropical Africa. The disease can be caused by two Trypanosoma brucei subspecies: Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense; each one is transmitted by a different Glossina subspecies [72]. T. brucei gambiense is the most prevalent subspecies; it is anthoponotic and endemic in central and western Africa whereas T. brucei rhodesiense is zoonotic and endemic in the south and east of Africa, sporadically affecting humans [73].…”

Section: Human African Trypanosomiasis (Sleeping Sickness)mentioning

confidence: 99%

Loop-Mediated Isothermal Amplification as Point-of-Care Diagnosis for Neglected Parasitic Infections

Avendaño

Patarroyo

2020

IJMS

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The World Health Organisation (WHO) has placed twenty diseases into a group known as neglected tropical diseases (NTDs), twelve of them being parasitic diseases: Chagas’ disease, cysticercosis/taeniasis, echinococcosis, food-borne trematodiasis, human African trypanosomiasis (sleeping sickness), leishmaniasis, lymphatic filariasis, onchocerciasis (river blindness), schistosomiasis, soil-transmitted helminthiasis (ascariasis, hookworm, trichuriasis), guinea-worm and scabies. Such diseases affect millions of people in developing countries where one of the main problems concerning the control of these diseases is diagnosis-based due to the most affected areas usually being far from laboratories having suitable infrastructure and/or being equipped with sophisticated equipment. Advances have been made during the last two decades regarding standardising and introducing techniques enabling diagnoses to be made in remote places, i.e., the loop-mediated isothermal amplification (LAMP) technique. This technique’s advantages include being able to perform it using simple equipment, diagnosis made directly in the field, low cost of each test and the technique’s high specificity. Using this technique could thus contribute toward neglected parasite infection (NPI) control and eradication programmes. This review describes the advances made to date regarding LAMP tests, as it has been found that even though several studies have been conducted concerning most NPI, information is scarce for others.

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“…Trypanosomiasis in the central and western regions of Africa is a slow-progressing form caused by T. brucei gambiense . Both trypanosomes invade the brain, causing mental deterioration, coma and death if left untreated [ 4 , 5 ]. There is also Surra, which is a trypanosomiasis caused by T. evansi, that affects wild and domestic animals mainly in Africa, Asia and South America, causing serious economic losses due to mortality and morbidity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Trypanocidal Essential Oils: A Review

et al. 2020

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Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.

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Human African Trypanosomiasis

Cited by 45 publications

References 75 publications

Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity

Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity

Loop-Mediated Isothermal Amplification as Point-of-Care Diagnosis for Neglected Parasitic Infections

Trypanocidal Essential Oils: A Review

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