Human adjuvant disease: remission of silicone induced autoimmune disease after explanation of breast augmentation.

Kaiser, W; Biesenbach, Georg; Stuby, U; Grafinger, P; Zazgórnik, J

doi:10.1136/ard.49.11.937

Cited by 66 publications

(18 citation statements)

References 18 publications

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“…5). The distinction between two groups of the same population gave a difference statistically significant, at P = .0001 between unexposed and silicone-exposed lymphocytes from augmented patients (11,583 incorporation of silicone-exposed Ly of reconstructed patients (rec-sil) was not different from unexposed lymphocytes (con), while silicone-exposed Ly of augmented patients (aug-sil) showed a significantly different incorporation (P = .01).…”

Section: Uptake Of 3h-tdr After Exposure Of Ly To Silicone Formentioning

confidence: 73%

Assessment of viability and proliferation of in vivo silicone‐primed lymphocytes after in vitro re‐exposure to silicone

Ciapetti

Granchi

Stea

et al. 1995

J. Biomed. Mater. Res.

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The functional response of peripheral blood lymphocytes isolated from 22 patients with silicone gel-filled breast implants was assessed after in vitro re-exposure to silicone. Using cell culture test methods to quantify proliferation and viability and/or activation of lymphocyte microcultures, i.e., the uptake of tritiated thymidine (3H-TdR uptake test) and the reduction of formazan salts (MTT assay), interesting data were obtained. Peripheral blood lymphocytes purified from patients wearing silicone gel-filled breast implants react in vitro to silicone showing a statistically significant increase of both proliferation and viability, while healthy subjects do not respond on in vitro exposure to silicone. Differences resulted even more statistically significant when patients were divided into two groups depending on the type of surgery they underwent: patients with breast augmentation for aesthetic reasons seem to have an increased responsiveness in vitro to silicone compared to patients who experienced a reconstructive surgery of the breast. Although they are still preliminary, being referred to a limited population, these results suggest that the lymphocytes of patients with silicone gel-filled breast implants could be sensitized in vivo toward silicone; the re-exposure of these cells to silicone leads to a higher functional response which could be looked for by using quantitative in vitro test methods.

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Section: Uptake Of 3h-tdr After Exposure Of Ly To Silicone Formentioning

confidence: 73%

Assessment of viability and proliferation of in vivo silicone‐primed lymphocytes after in vitro re‐exposure to silicone

Ciapetti

Granchi

Stea

et al. 1995

J. Biomed. Mater. Res.

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show abstract

“…(4) The presence of serologic abnormalities such as autoantibodies [15,17]. (5) The symptoms improved after the removal of the foreign material [10]. (6) No infection or malignancy existed in the operated region.…”

Section: Discussionmentioning

confidence: 98%

Silicone granulomas: 30 years after injection of fluid silicone for breast and inner thigh augmentation – a possible case of human adjuvant disease improved after massive siliconomas removal

et al. 1998

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“…Silicone has been suspected of promoting an immuno logical adjuvant effect in people receiving breast implants [14], The mechanism by which silicone may produce an ad- 406 Teuber/Howell/Yoshida/Gershwin Sarcoid Remission juvant effect is not currently known. However, silicone gel was recently shown to enhance both the humoral and the delayed-type hypersensitivity response of rats to bovine se rum albumin [15,16].…”

Section: Discussionmentioning

confidence: 99%

Remission of Sarcoidosis following Removal of Silicone Gel Breast Implants

Teuber

Howell²,

Yoshida

et al. 1994

Int Arch Allergy Immunol

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We report herein a patient with debilitating multisystem sarcoidosis. Interestingly, dermal lesions and enlarged lymph nodes resolved and her clinical condition dramatically improved following removal of silicone gel breast implants. Of note, the capsular tissue surrounding the breast implant demonstrated a granulomatous foreign-body response. The potential harmful effects of silicone may include an acceleration of an already existing hypersensitivity response.

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Human adjuvant disease: remission of silicone induced autoimmune disease after explanation of breast augmentation.

Abstract: We present a 42 year old woman with autoimmune phenomena following breast augmentation, and remission after explantation.

Cited by 66 publications

References 18 publications

Assessment of viability and proliferation of in vivo silicone‐primed lymphocytes after in vitro re‐exposure to silicone

Assessment of viability and proliferation of in vivo silicone‐primed lymphocytes after in vitro re‐exposure to silicone

Silicone granulomas: 30 years after injection of fluid silicone for breast and inner thigh augmentation – a possible case of human adjuvant disease improved after massive siliconomas removal

Remission of Sarcoidosis following Removal of Silicone Gel Breast Implants

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