Human Adipose Tissue-Derived Mesenchymal Stem Cells Abrogate Plasmablast Formation and Induce Regulatory B Cells Independently of T Helper Cells

Franquesa, Marcella; Mensah, F.; Huizinga, Ruth; Strini, Tanja; Boon, Louis; Lombardo, Eleuterio; DelaRosa, Olga; Laman, Jon D.; Grinyó, Josep M.; Weimar, Willem; Betjes, Michiel G. H.; Baan, Carla C.; Hoogduijn, Martin J.

doi:10.1002/stem.1881

Cited by 184 publications

(178 citation statements)

References 55 publications

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“…In fact, while ADSCs can inhibit the proliferation of B cells, they can induce regulatory B cells (Franquesa et al, 2015) and induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA (Engela et al, 2013). ADSCs can also successfully inhibit the allergic airway inflammation via immuno-modulation from a Th2 to a Th1-biased response in the mouse model (Cho and Roh, 2010).…”

Section: Discussionmentioning

confidence: 99%

Expanded autologous adipose derived stem cell transplantation for type 2 diabetes mellitus

Pham

et al. 2016

Biomed Res Ther

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Introduction: Type 2 diabetes mellitus (T2D) is the most common form of diabetes mellitus, accounting for 90% of diabetes mellitus in patients. At the present time, although T2D can be treated by various drugs and therapies using insulin replacement, reports have shown that complications including microvascular, macrovascular complications and therapy resistance can occur in patients on long term treatment. Stem cell therapy is regarded as a promising therapy for diabetes mellitus, including T2D. The aim of this study was to evaluate the safety and therapeutic effect of expanded autologous adipose derived stem cell (ADSC) transplantation for T2D treatment; the pilot study included 3 patients who were followed for 3 months. Methods: The ADSCs were isolated from stromal vascular fractions, harvested from the belly of the patient,and expanded for 21 days per previously published studies. Before transplantation, ADSCs were evaluated for endotoxin, mycoplasma contamination, and karyotype.All patients were transfused with ADSCs at 1-2x10 6 cells/kg of body weight.Patients were evaluated for criteria related to transplantation safety and therapeutic effects; these included fever, blood glucose level before transplantation of ADSCs, and blood glucose level after transplantation (at 1, 2 and 3 months). Results: The results showed that all samples of ADSCs exhibited the MSC phenotype with stable karyotype (2n=46), there was no contamination of mycoplasma, and endotoxin levels were low (<0.25 EU/mL). No adverse effects were detected after 3 months of transplantation. Decreases of blood glucose levels were recorded in all patients. Conclusion: The findings from this initial study show that expanded autologous ADSCs may be a promising treatment for T2D.

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Section: Discussionmentioning

confidence: 99%

Expanded autologous adipose derived stem cell transplantation for type 2 diabetes mellitus

Pham

et al. 2016

Biomed Res Ther

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“…These properties are mediated by the release of soluble paracrine factors and by direct cell-tocell interactions with professional antigen presenting cells (APCs) such as dendritic cells, 79 T cells, 80,81 B cells 82 and macrophages. 83 ADSCs are able to block APCs maturation in a contactdependent manner, to induce the expression of anti-inflammatory cytokines such as IL-10 and to enhance TGF-b activity.…”

Section: Adscs Application For Wound Healing Therapymentioning

confidence: 99%

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

et al. 2015

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(2015) Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds, Organogenesis, 11:4, 183-206, DOI: 10.1080/15476278.2015 ABSTRACT. Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies.Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

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“…Other effects on B cells by MSCs include suppression of terminal differentiation [67], in vitro inhibition of antibody production [68], and downregulation of factors necessary for chemotaxis [69]. ASCs, in particular, can induce the development of a regulatory B cell population, further controlling B cell activity [70]. MSCs have been known to suppress activity of NK cells with regards to IFN-γ secretion and proliferation [51,71,72].…”

Section: Effects On B Lymphocytesmentioning

confidence: 99%

The promising role for adipose-derived mesenchymal stem cells in tissue regeneration

Arun¹,

Lee²,

Brandacher³

et al. 2016

Nanomaterials and Regenerative Medicine

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Human Adipose Tissue-Derived Mesenchymal Stem Cells Abrogate Plasmablast Formation and Induce Regulatory B Cells Independently of T Helper Cells

Cited by 184 publications

References 55 publications

Expanded autologous adipose derived stem cell transplantation for type 2 diabetes mellitus

Expanded autologous adipose derived stem cell transplantation for type 2 diabetes mellitus

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

The promising role for adipose-derived mesenchymal stem cells in tissue regeneration

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