Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning

Schwerk, Anne; Altschüler, Jennifer; Roch, Manfred; Gossen, Manfred; Winter, Christine; Berg, Jürgen; Kurtz, Armin; Steiner, Barbara

doi:10.1016/j.jcyt.2014.09.005

Cited by 40 publications

(44 citation statements)

References 69 publications

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“…Similar results were found in our previously published short-term study, which showed higher neurogenesis in the SVZ of AD-MSC treated rats versus only 6-OHDA lesioned rats [29]. Similar results were found in our previously published short-term study, which showed higher neurogenesis in the SVZ of AD-MSC treated rats versus only 6-OHDA lesioned rats [29].…”

Section: Discussionsupporting

confidence: 91%

“…Furthermore, adipose-derived MSC (AD-MSC) show higher proliferative capacity, later senescence and a higher level of neurotrophin secretion than bone-marrow-derived MSC [23][24][25]. Furthermore, another short-term study from our lab showed increased neurogenesis upon AD-MSC transplantation in comparison to Parkinsonian rats without AD-MSC treatment [29]. Furthermore, another short-term study from our lab showed increased neurogenesis upon AD-MSC transplantation in comparison to Parkinsonian rats without AD-MSC treatment [29].…”

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confidence: 92%

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Adipose-Derived Human Mesenchymal Stem Cells Induce Long-Term Neurogenic and Anti-Inflammatory Effects and Improve Cognitive but not Motor Performance in a Rat Model of Parkinson's Disease

et al. 2015

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Section: Discussionsupporting

confidence: 91%

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confidence: 92%

Adipose-Derived Human Mesenchymal Stem Cells Induce Long-Term Neurogenic and Anti-Inflammatory Effects and Improve Cognitive but not Motor Performance in a Rat Model of Parkinson's Disease

et al. 2015

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“…16 Similar effects were reported with adipose tissueederived and umbilical cordederived MSCs with or without prior differentiation. [162][163][164][165][166][167][168][169] For example, in a study using autologous transplant into the substantia nigra, McCoy et al 164 reported improvement of motor function, reduced microglial activation, and decreased loss of tyrosine hydroxylase immunoreactivity, associated with local production of trophic factors. Intrastriatal administration was furthermore reported to enhance neurogenesis in the subventricular zone and to induce neuroblast migration to the striatum.…”

Section: Parkinson Diseasementioning

confidence: 99%

Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases

Staff

Jones

Singer

2019

Mayo Clinic Proceedings

118

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Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of medical conditions. Over the past decade, there has been considerable excitement about using MSCs to treat neurodegenerative diseases, which are diseases that are typically fatal and without other robust therapies. In this review, we discuss the proposed MSC mechanisms of action in neurodegenerative diseases, which include growth factor secretion, exosome secretion, and attenuation of neuroinflammation. We then provide a summary of preclinical and early clinical work on MSC therapies in amyotrophic lateral sclerosis, multiple system atrophy, Parkinson disease, and Alzheimer disease. Continued rigorous and controlled studies of MSC therapies will be critical in order to establish efficacy and protect patients from possible untoward effects. ª 2019 Mayo Foundation for Medical Education and Research n Mayo Clin Proc. 2019;94(5):892-905

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“…Autologous ASCs were transplanted into the SN of rats, 1 week after the medial forebrain bundle was fully lesioned by injections of 6‐OHDA (Schwerk et al, ). As early as 3 days after transplantation, an increased SVZ neurogenesis was detected, as compared to non‐transplanted rats.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases

Furno

Mannino

Giuffrida

2017

Journal Cellular Physiology

132

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Mesenchymal stem cells (MSCs) can differentiate into not only cells of mesodermal lineages, but also into endodermal and ectodermal derived elements, including neurons and glial cells. For this reason, MSCs have been extensively investigated to develop cell-based therapeutic strategies, especially in pathologies whose pharmacological treatments give poor results, if any. As in the case of irreversible neurological disorders characterized by progressive neuronal death, in which behavioral and cognitive functions of patients inexorably decline as the disease progresses. In this review, we focus on the possible functional role exerted by MSCs in the treatment of some disabling neurodegenerative disorders such as Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease, and Parkinson's Disease. Investigations have been mainly performed in vitro and in animal models by using MSCs generally originated from umbilical cord, bone marrow, or adipose tissue. Positive results obtained have prompted several clinical trials, the number of which is progressively increasing worldwide. To date, many of them have been primarily addressed to verify the safety of the procedures but some improvements have already been reported, fortunately. Although the exact mechanisms of MSC-induced beneficial activities are not entirely defined, they include neurogenesis and angiogenesis stimulation, antiapoptotic, immunomodulatory, and anti-inflammatory actions. Most effects would be exerted through their paracrine expression of neurotrophic factors and cytokines, mainly delivered at damaged regions, given the innate propensity of MSCs to home to injured sites. Hopefully, in the near future more efficacious cell-replacement therapies will be developed to substantially restore disease-disrupted brain circuitry.

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Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning

Cited by 40 publications

References 69 publications

Adipose-Derived Human Mesenchymal Stem Cells Induce Long-Term Neurogenic and Anti-Inflammatory Effects and Improve Cognitive but not Motor Performance in a Rat Model of Parkinson's Disease

Adipose-Derived Human Mesenchymal Stem Cells Induce Long-Term Neurogenic and Anti-Inflammatory Effects and Improve Cognitive but not Motor Performance in a Rat Model of Parkinson's Disease

Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases

Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases

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