Huge Fetal Sacrococcygeal Teratoma with a Completely Formed Eye and Intratumoral DNA Ploidy Heterogeneity

Sergi, Consolato; Ehemann, Volker; Beedgen, B.; Linderkamp, Otwin; Otto, Herwart F.

doi:10.1007/s100249900089

Cited by 26 publications

(22 citation statements)

References 35 publications

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“…The ovoid homogeneous lamellar structures recognized in the central nervous tissue were considered to be a crystalline lens. There was a human case of a sacrococcygeal teratoma with a completely formed eye in 29 weeks-infants, but there have been no papers reporting crystalline lens in canine teratomas [23]. However, it is sufficiently possible to being differentiated for optic that the optic structures can be differentiated from the tumor cells when considered their multipotential nature.…”

mentioning

confidence: 99%

Ovarian Teratoma with a Formed Lens and Nonsuppurative Inflammation in an Old Dog

Yamaguchi

Sato

Shibuya

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. A 9-year, 7-month-old female German shepherd weighing 26.6 kg was admitted to the hospital for pica and diarrhea. A large mass was found in the right ovary and removed, and cross section of the mass revealed a multilobular tumor consisting of several cystic cavities which contained tufts of dark hair in thick creamy-white sebaceous fluid. Histologically, the tumor consisted of adipose tissue, central nervous tissue, crystalline lens, cartilage and bone. In the central nervous tissue, lens and lesions like nonsuppurati ve inflammation comprizing of accumulation of glial cells and lymphocytic perivascular cuffing were observed. The tumor was diagnosed as a mature cystic teratoma.

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confidence: 99%

Ovarian Teratoma with a Formed Lens and Nonsuppurative Inflammation in an Old Dog

Yamaguchi

Sato

Shibuya

et al. 2004

The Journal of Veterinary Medical Science

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“…Teratomas with a retina-like structure have been reported and some of the cases showed a complete or partial eye structure (9). A retrospective search in our medical center revealed that 2 out of 7 cases of sacrococcygeal teratoma of newborns had retina-like structures; one is the present case and the other showed an incompletely stratified retinal structure associated with retinal markers.…”

Section: Discussionmentioning

confidence: 58%

Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

et al. 2012

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Abstract. Teratoma is a tumor that forms triploblastic tissues and the common sites of occurrence are sacrococcygeal lesions and the ovaries. The majority of cases are curable with surgical resection and the prognosis depends on the extent and histological scoring of the tumor. In the present study, we report a case of sacrococcygeal teratoma of a newborn showing features of a retina-like structure. A 29-year-old woman gave birth prematurely to an infant girl with sacrococcygeal teratoma. Surgical resection was performed 10 days after delivery. The tumor contained immature components as well as a retina-like structure. Several investigations, including immunohistochemical analysis, confirmed the similarities between the normal mouse retina and the retina-like structure of the tumor. The vascular arrangement and polarity surrounding the retina-like structure are unique and this is thought to be significant in the induction of structural differentiation. Our findings may provide insights into the matter of teratogenic activity in stem cell therapies for clinical applications.

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“…For example, one article states that aggregates ''resemble normal embryonic development much closer than previously thought,'' exhibiting ''an unexpected degree of self-organization'' [97]. Yet stem cell aggregates do not resemble organisms so much as they resemble tumors, which can also show a surprising degree of self-organization, producing well-formed teeth [98] and, even in one case, a remarkably normal eye [99].…”

Section: Behaving Like Part Of An Embryo or Merely Looking Like An Emmentioning

confidence: 95%

Totipotency: What It Is and What It Is Not

Condic

2014

Stem Cells and Development

118

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There is surprising confusion surrounding the concept of biological totipotency, both within the scientific community and in society at large. Increasingly, ethical objections to scientific research have both practical and political implications. Ethical controversy surrounding an area of research can have a chilling effect on investors and industry, which in turn slows the development of novel medical therapies. In this context, clarifying precisely what is meant by ''totipotency'' and how it is experimentally determined will both avoid unnecessary controversy and potentially reduce inappropriate barriers to research. Here, the concept of totipotency is discussed, and the confusions surrounding this term in the scientific and nonscientific literature are considered. A new term, ''plenipotent,'' is proposed to resolve this confusion. The requirement for specific, oocyte-derived cytoplasm as a component of totipotency is outlined. Finally, the implications of twinning for our understanding of totipotency are discussed. HighlightsInaccurate use of the term ''totipotent'' by scientists creates unnecessary ethical controversy. Public concern over producing embryos by reprogramming reflects confusion over totipotency. Twinning by blastocyst splitting does not provide scientific evidence for totipotency.What Is Totipotency?

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Huge Fetal Sacrococcygeal Teratoma with a Completely Formed Eye and Intratumoral DNA Ploidy Heterogeneity

Cited by 26 publications

References 35 publications

Ovarian Teratoma with a Formed Lens and Nonsuppurative Inflammation in an Old Dog

Ovarian Teratoma with a Formed Lens and Nonsuppurative Inflammation in an Old Dog

Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

Totipotency: What It Is and What It Is Not

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