Stroke is the second cause of death in the world. As many as 15.4% of all deaths in Indonesia are caused by strokes. The prevalence of stroke increases from year to year and will cause problems in the health sector. One of the factors can exacerbate stroke, including sleep disturbances. The aim of this article is to examine the relationship between sleep disturbances and the effect of cytokines on ischemic stroke outcome. Ischemic stroke due to atherosclerosis in the presence of hypoxia in neuron will result in the release of cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) from neurons and glial cells. Cytokines also influence sleep patterns such as nerve growth factor (NGF) inducing non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM). Sleep disorders, especially sleep apnea, have a greater risk of stroke or risk of death for any cause. The process that occurs in acute ischemic stroke causes an inflammatory response, this inflammatory process is like a double-edged sword because on the one hand it causes more extensive damage, but on the other hand it can act help repair. Increased production of cytokines such as interleukin-10 (IL-10), IL-6, and C-reactive protein (CRP) will lead to poor outcomein stroke patients.