Hubungan antara Faktor Klinikohistopatologi dan Kualitas Hidup Pasien Kanker Endometrium Pasca Operasi di RSUP Dr.Sardjito Yogyakarta Menggunakan Modul Kuesioner EORTC QLQ-C30 dan EN 24

Abstract

Background: According to data from the "Endometrial Cancer Report" by the World Cancer Research Fund and the American Institute for Cancer Research (WCRFI), endometrial cancer is the sixth most common malignancy in the world and is the largest cancer in female organs, after cervical cancer. This incidence is increasing every year, it is predicted to increase about 5% of new cases each year. The main prognostic factors of endometrial cancer are determined by the histological type, stage, degree, differentiation of the tumor, invasive myometrial level and increase in lympho-vascular invasion. In addition to determining the histopathological factors, the prognosis is also determined from the clinical patient. Several studies have shown certain clinical factors also improve the condition and prognosis of the disease. Prognosis of this disease with the quality of life of patients becomes an interesting topic to discuss. Besides that quality of life is also a measure of therapeutic success. The better the prognosis of a disease, the better the quality of life, the higher the success rate of therapy (Greimel, 2010).Objective: To know correlation between clinicohistopathological and quality of life in patients with endometrial cancer after undergoing surgery at Sardjito Hospital, Yogyakarta.Method: The research is analytic with cross sectional approach. Patients with endometrial cancer who have undergone total hysterectomy and bisalpingoophorectomy surgery are assessed for their quality of life through interviews and filling out questionnaires in the EORTC QLQ-C 30 and QLQ-EN 24 modules.Results and Discussion: This study, most people with endometrial cancer aged 55-65 years were 34 people (42%) and diagnosed after menopause with a range of age >55 years as many as 43 people (53.1%). This study cannot prove the hypothesis that age, parity, body mass index, type of histopathology and KGB involvement have a relationship with the quality of life of cancer patients (p >0.05). But in contrast to the stage of early cancer (OR 3.17, p=0.044 (CI 95% 1.03-9.75)) and good and moderate differentiation (OR 4.471, p=0.023 (CI 95% 1.23-16.24)) have a significant relationship with quality of life.Conclusion: Clinicohistopathological factors (cancer stage and tumor differentiation) have a correlation with the quality of life at patients with postoperative endometrial cancer in Sardjito Hospital Keywords: Endometrial cancer; clinicohistopathological factors; quality of life

Gambaran Faktor Risiko Kanker Endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022

“…di RSUP Dr. Sardjito Yogyakarta dengan status paritas multipara sebanyak 31 kasus (38,30%). 12 Akan tetapi, hasil penelitian ini berbeda dengan artikel jurnal yang ditulis oleh Chen, dkk., yaitu kasus kanker endometrium banyak dialami wanita dengan 1 kelahiran hidup atau primipara sebanyak 53,4% pasien serta diikuti oleh status paritas multipara dengan 2 kelahiran hidup (27,7%) dan ≥3 kelahiran hidup (13,3%). 13 Hubungan status paritas dengan kejadian kanker endometrium yaitu faktor kadar hormon estrogen yang rendah dan kadar hormon progesteron yang tinggi selama kehamilan berkaitan dengan efek perlindungan oleh fungsi hormon progesteron untuk menghambat proliferasi sel dan sebagai stimulator diferensiasi sel di endometrium.…”

“…mengatakan bahwa pasien kanker endometrium lebih banyak yang tidak mengalami obesitas yaitu sebanyak 64 kasus (79,0%). 12 Perbedaan usia menarche dapat memengaruhi terjadinya kanker endometrium. Menurut Fuhrman, dkk., wanita yang mengalami menarche lebih cepat dapat menyebabkan terjadinya paparan estrogen terhadap endometrium yang lebih lama sehingga meningkatkan aktivitas mitosis, replikasi DNA, dan mutasi somatik sel endometrium yang bisa menyebabkan keganasan.…”