Hub gene of disulfidptosis-related immune checkpoints in breast cancer

Wang, Ye; Deng, Yuan-Run; Xie, Hui; Cao, Sujuan

doi:10.1007/s12032-023-02073-y

Cited by 8 publications

(7 citation statements)

References 37 publications

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“…This presents a novel therapeutic strategy for cancer treatment. While the exact molecular mechanisms of disulfidptosis in tumors require further investigation, a tumor prognosis model based on it has been outlined [ [37] , [38] , [39] ].…”

Section: Discussionmentioning

confidence: 99%

The development of prognostic gene markers associated with disulfidptosis in gastric cancer and their application in predicting drug response

Liu,

2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

The development of prognostic gene markers associated with disulfidptosis in gastric cancer and their application in predicting drug response

Liu,

2024

Heliyon

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“…Additionally, the inhibitors of ferroptosis, apoptosis, necroptosis and autophagy could not reverse this particular cell death [6]. Currently, disul dptosis has been studied in BRCA through the use of bioinformatics approaches [9,11,12]. However, this study innovatively gathers disul dptosis and ferroptosis genes to comprehensively describe how disul dptosis and ferroptosis related-genes patterns are clinically signi cant and how they may be related to TME features.…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular characteristics associated with disulfidptosis and ferroptosis-related genes in breast cancer, along with immune cell infiltration Analysis and Development of a prognostic risk model

Pei,

Wang,

Zhao

et al. 2023

Preprint

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Background Breast cancer (BRCA) is a common and highly heterogeneous malignancy with a relative poor prognosis. Disulfidptosis is a newly discovered mode of cell death induced by disulfide stress. Like ferroptosis, disulfidptosis is a novel form of programmed cell death. The goal of this research was to explore new biomarkers associated with disulfidptosis and ferroptosis that can guide the treatment of BRCA. Methods We collected expression and clinical information about BRCA patients from public database. We comprehensively characterized the relationship between disulfidptosis and ferroptosis-related genes and the molecular characteristics as well as immune cell infiltration of tumor tissue. Next, a risk model was identified based on COX regression model with least absolute shrinkage and selection operator regression (LASSO) algorithm. Besides, we evaluated the prognostic value and treatment sensitivity of various subtypes. Results Specific molecular characteristics and model possessed a promising predictive potential. Immune infiltration and treatment sensitivity analysis all showed differences between groups. Conclusions Our molecular subtypes and risk model, with strong immune prediction and prognostic prediction capabilities, are committed to guiding BRCA treatment.

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“…The expression of disulfidptosis related gene CTSE is increased in BC tissues, which promotes the proliferation and metastasis of BC cells [ 58 ]. In addition, the disulfidptosis score can predict the prognosis of cervical cancer [ 59 ], breast cancer [ 60 ], lung adenocarcinoma [ 61 ], thyroid cancer [ 62 ] and renal cell carcinoma [ 63 ].…”

Section: Molecular Mechanisms Of Different Cell Death Pathwaysmentioning

confidence: 99%

Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

Zhou,

Liu,

Wan

et al. 2024

J Hematol Oncol

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Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.

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Hub gene of disulfidptosis-related immune checkpoints in breast cancer

Cited by 8 publications

References 37 publications

The development of prognostic gene markers associated with disulfidptosis in gastric cancer and their application in predicting drug response

The development of prognostic gene markers associated with disulfidptosis in gastric cancer and their application in predicting drug response

Identification of molecular characteristics associated with disulfidptosis and ferroptosis-related genes in breast cancer, along with immune cell infiltration Analysis and Development of a prognostic risk model

Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

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