Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5

Liu, Qingping; Yang, Yizhe; Wu, Mengqi; Wang, Mengruo; Yang, Peihao; Zheng, Jie; Du, Zhe; Pang, Yaxian; Bao, Lei; Niu, Yujie; Zhang, Rong

doi:10.1016/j.jhazmat.2023.133190

Journal of Hazardous Materials

2024

DOI: 10.1016/j.jhazmat.2023.133190

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Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5

Qingping Liu,

Yizhe Yang,

Mengqi Wu

et al.

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2024

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Chronic diesel exhaust exposure induced pulmonary vascular remodeling a potential trajectory for traffic related pulmonary hypertension

Mu,

Li,

Niu

et al. 2024

Respir Res

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Background As one of the most common traffic-related pollutants, diesel exhaust (DE) confers high risk for cardiovascular and respiratory diseases. However, its impact on pulmonary vessels is still unclear. Methods To explore the effects of DE exposure on pulmonary vascular remodeling, our study analyzed the number and volume of small pulmonary vessels in the diesel engine testers (the DET group) from Luoyang Diesel Engine Factory and the controls (the non-DET group) from the local water company, using spirometry and carbon content in airway macrophage (CCAM) in sputum. And then we constructed a rat model of chronic DE exposure, in which 12 rats were divided into the DE group (6 rats with 16-week DE exposure) and the control group (6 rats with 16-week clean air exposure). During right heart catheterization, right ventricular systolic pressure (RVSP) was assessed by manometry. Macrophage migration inhibitory factor (MIF) in lung tissues and bronchoalveolar lavage fluid (BALF) were measured by qRT-PCR and ELISA, respectively. Histopathological analysis for cardiovascular remodeling was also performed. Results In DET cohort, the number and volume of small pulmonary vessels in CT were positively correlated with CCAM in sputum ( P <0.05). Rat model revealed that chronic DE-exposed rats had elevated RVSP, along with increased wall thickness of pulmonary small vessels and right the ventricle. What’s more, the MIF levels in BALF and lung tissues were higher in DE-exposed rats than the controls. Conclusion Apart from airway remodeling, DE also induces pulmonary vascular remodeling, which will lead to cardiopulmonary dysfunction. Supplementary Information The online version contains supplementary material available at 10.1186/s12931-024-02976-y.

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Chronic diesel exhaust exposure induced pulmonary vascular remodeling a potential trajectory for traffic related pulmonary hypertension

Mu,

Li,

Niu

et al. 2024

Respir Res

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Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5

Cited by 1 publication

References 68 publications

Chronic diesel exhaust exposure induced pulmonary vascular remodeling a potential trajectory for traffic related pulmonary hypertension

Chronic diesel exhaust exposure induced pulmonary vascular remodeling a potential trajectory for traffic related pulmonary hypertension

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