Huangqi Guizhi Wuwu decoction for diabetic peripheral neuropathy

Abstract

Background: Diabetic peripheral neuropathy (DPN) is one of the most common causes of disability in diabetic population, and its pathogenesis is related to a variety of factors. There is currently no effective treatment for such chronic disease. Traditional Chinese medicine has a long clinical history for the prevention and treatment of diabetes and chronic complications, and it also shows certain advantages in the treatment of DPN. Many clinical studies have confirmed that Chinese medicine Huangqi Guizhi Wuwu decoction (HGWD) can reduce the clinical symptoms and improve neuronal function of patients with DPN. So we intend to conduct a systematic review further clarified the effectiveness and safety of HGWD for DPN. Methods: We will search each database from the built-in until June 2019. The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science, while the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Simultaneously we will retrieval clinical registration tests and grey literatures. This study only screen the clinical randomized controlled trials (RCTs) about HGWD for DPN to assess its efficacy and safety. The 2 researchers worked independently on literature selection, data extraction, and quality assessment. The dichotomous data is represented by relative risk (RR), and the continuous is expressed by mean difference (MD) or standard mean difference (SMD), eventually the data is synthesized using a fixed effect model (FEM) or a random effect model (REM) depending on whether or not heterogeneity exists. The clinical efficacy, median sensory nerve conduction velocity, median motor nerve conduction velocity, peroneal sensory nerve conduction velocity, and peroneal motor nerve conduction velocity were evaluated as the main outcomes. Fasting blood glucose, 2 hours postprandial blood glucose, hemorheology, and adverse reactions were secondary outcomes. Finally, meta-analysis was conducted by RevMan software version 5.3. Results: This study will synthesize and provide high-quality evidence based on the data of the currently published HGWD for the treatment of DPN, especially in terms of clinical efficacy, neurological function, blood glucose, hemorheology, and safety. Conclusion: This systematic review aims to provide new options for HGWD treatment of DPN in terms of its efficacy and safety. PROSPERO registration number: PROSPERO 2019 CRD42019132031.

Herbal Formula Huangqi Guizhi Wuwu Decoction Attenuates Paclitaxel-related Neurotoxicity via Inhibition of Inflammation and Oxidative Stress

“…This prescription has long been used to control pain and numbness in stroke sequelae, peripheral nerve injury, and other diseases. Recent studies and our work suggest that HGWD is therapeutically effective for diabetic and oxaliplatin-induced peripheral neuropathy [12,13]. HGWD improved neurological function, increased blood circulation and alleviated oxaliplatininduced mechanical and cold hypersensitivity, suggesting that HGWD may offer potential opportunities to CIPN treatment.…”

“…Herbal formula HGWD has been used to treat numbness, vibration sensation, cold sensation, and limb ache since the Eastern Han Dynasty, which is considered a potential complementary therapy providing neuronal protection in chemotherapy [16]. Recently, HGWD has been proven to be effective in treating oxaliplatin-and diabetic peripheral neuropathy in animal models and clinical studies [12,13]. However, the effect of HGWD on PIPN with its pharmacological mechanism remains unclear, Thus, in this study, we tested whether HGWD alleviates PIPN and explore the underlying pharmacological mechanism.…”

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

“…Recent clinical evidence-based studies have shown that HGWWD has a positive therapeutic effect on various cardiovascular and cerebrovascular diseases. For example, HGWWD can improve cerebral blood flow in stroke patients and alleviate the subjective symptoms of diabetic peripheral neuropathy (Baiqing, 2015;Pang et al, 2016). Similarly, a recent study reported that HGWWD effectively treated lower extremity macroangiopathy in diabetic patients (Hu et al, 2018).…”

Efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy

“…[ 20 ] The mechanism of traditional Chinese medicine in treating DPN is protecting pancreatic cells, improving blood glucose and lipids, and delaying the disease's progression by antioxidant therapy. [ 21 , 22 ] Studies show that using three traditional Chinese medicine injections, including Danhong injection, Ginkgo leaf injection, and Danshen Chuanxiongqin injection, are better than using mecobalamin only in the adjuvant treatment of DPN. [ 23 ] The main components are tanshinone, Salviol, ginkgo biloba extract of Safflower, etc.…”