2015
DOI: 10.1016/j.jep.2015.07.036
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Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid

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Cited by 76 publications
(75 citation statements)
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“…ASA decreased the phosphorylation of p38 and ERK, but it did not affect the phosphorylation of JNK ( Figure 5A). We are interested in the role of p38 in ASA inhibiting autophagy because of its importance in fibrosis [12,13] . The p38 inhibitor SB203580 increased LC3-II levels in basal and ASA-treated CFs ( Figure 5B), which suggested that p38 regulated autophagy.…”
Section: Asa Alleviates Cf Proliferation By Inhibiting Autophagymentioning
confidence: 99%
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“…ASA decreased the phosphorylation of p38 and ERK, but it did not affect the phosphorylation of JNK ( Figure 5A). We are interested in the role of p38 in ASA inhibiting autophagy because of its importance in fibrosis [12,13] . The p38 inhibitor SB203580 increased LC3-II levels in basal and ASA-treated CFs ( Figure 5B), which suggested that p38 regulated autophagy.…”
Section: Asa Alleviates Cf Proliferation By Inhibiting Autophagymentioning
confidence: 99%
“…In addition, p38 activation is involved in the fibrosis of various organs. Inhibition of p38 can attenuate renal fibrosis, and the activation of p38 can promote liver fibrosis [12,13] , although whether p38 participates in the ASAinduced anti-fibrosis process and its relationship with autophagy remain unknown.…”
Section: Introductionmentioning
confidence: 99%
“…Cumulative evidence suggests that these managements can preserve renal function and prevent or slow the progression of DN (15)(16)(17). Isorhamnetin (ISO) is a plant flavonoid abundant in herbal medicinal plants, such as Hippophae rhamnoides L. In recent Involvement of the NF-κB signaling pathway in the renoprotective effects of isorhamnetin in a type 2 diabetic rat model studies, ISO exhibited strong antioxidant and anti-inflammatory properties.…”
Section: Introductionmentioning
confidence: 99%
“…Reactive oxygen species (ROS), caused by oxidative stress, play a major part in DN. Regulation focused on oxidative stress and ROS can ameliorate urinary albumin and renal dysfunction including blood urea nitrogen and uric acid in DN rats (Mao et al, 2015). In addition, reduction of oxidative stress attenuates glomerulus hypertrophy and expansion of the mesangial area, swell and effacement of foot process (Cai et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…The nuclear factor erythroid-2-related factor 2 (Nrf2) has been shown to be the important mechanism to alleviate oxidative stress (Ma, 2013). Nrf2 is a transcription factor that regulates the expression of various cytoprotective enzymes.…”
Section: Introductionmentioning
confidence: 99%