Hu Antigen Specificities of ANNA-I Autoantibodies in Paraneoplastic Neurological Disease

King, Peter H.; Redden, David T.; Palmgren, J.S; Nabors, L. Burt; Lennon, Vanda A.

doi:10.1006/jaut.1999.0337

Cited by 65 publications

(41 citation statements)

References 25 publications

(51 reference statements)

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“…Another Hu-family member, HuB, is expressed in both neurons and sex organs ( [108] and references therein). All four of the Hu-family proteins are target antigens in antibody-associated paraneoplastic encephalomyelitis sensory neuropathy (Hu syndrome) (reviewed in [109]). Like HuR, ELAV and the other Hu-family proteins all contain three RRMs.…”

Section: Hu-family Proteins Promote Cellular Differentiationmentioning

confidence: 99%

HuR and mRNA stability

Brennan¹,

Steitz²

2001

CMLS, Cell. Mol. Life Sci.

971

978

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An important mechanism of posttranscriptional gene regulation in mammalian cells is the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in their 3' untranslated regions. HuR, a ubiquitously expressed member of the Hu family of RNA-binding proteins related to Drosophila ELAV, selectively binds AREs and stabilizes ARE-containing mRNAs when overexpressed in cultured cells. This review discusses mRNA decay as a general form of gene regulation, decay signaled by AREs, and the role of HuR and its Hu-family relatives in antagonizing this mRNA degradation pathway. The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change.

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Section: Hu-family Proteins Promote Cellular Differentiationmentioning

confidence: 99%

HuR and mRNA stability

Brennan¹,

Steitz²

2001

CMLS, Cell. Mol. Life Sci.

971

978

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show abstract

“…The UNC-OSU group evaluated the prevalence of anti-ENS autoimmune antibodies and the antigens recognized by the antibodies in patients diagnosed with idiopathic IBS. The approach was based on one used productively for evaluation of anti-enteric neuronal antibodies in patients with gastrointestinal disorders associated with a paraneoplastic syndrome [37][38][39][40][41][42].…”

Section: Autoimmune Neuropathymentioning

confidence: 99%

Enteric Nervous System: Neuropathic Gastrointestinal Motility

Wood

2016

Dig Dis Sci

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“…Inflammatory neuropathies are characterized by a dense inflammatory infiltrate characterized by CD3 positive (composed of both CD4 and CD8) lymphocytes almost invariably confined to the myenteric plexus (hence the term of lymphocytic myenteric ganglionitis) [7][8][9]19] . The close apposition of CD3 lymphocytes to myenteric neurons provides the basis to neuro-immune interactions targeting and affecting ganglion cell structure and survival [20,21] .…”

Section: Enteric Neuropathies and Enteroglial Cell Abnormalitiesmentioning

confidence: 99%

“…anti-Hu anti-neuronal antibodies) also suggests the role of the immune system in neuronal dysfunction [19] . Previous results indicated that these autoantibodies alter ascending reflex pathway of peristalsis in in vitro preparations [22] and elicit neuronal hyperexcitability as demonstrated by Ca 2+ -imaging technique [23] .…”

Section: Enteric Neuropathies and Enteroglial Cell Abnormalitiesmentioning

confidence: 99%