https://researchopenworld.com/effect-of-propolis-nanoparticles-on-early-stage-wound-healing-in-a-diabetic-noncontractile-wound-model/#

doi:10.31038/nams.2019212

Cited by 2 publications

(2 citation statements)

References 25 publications

(31 reference statements)

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“…Clinical trial data suggest that although aspirin exhibits moderate anti-glycation effects when compared with propolis, 21.5% of diabetic patients may experience resistance to its effects, potentially resulting in cardiovascular complications. Another report also stated that the ethanol extract of nanopropolis from Southern Brazil provided a therapeutic effect for topical wound healing caused by diabetes mellitus by showing a better percentage of wound closure (54.5%), whose mechanism was supported by nanopropolis from Southern Brazil in inducing acceleration of the proliferation phase, collagen deposition, angiogenesis, thereby forming new skin tissue regeneration [ 100 ]. Finally, nanopropolis formulated with powder effectively treated diabetes by reducing blood sugar levels and regenerating damaged β cells in streptozotocin-induced diabetic mice [ 132 ].…”

Section: Pharmacological Actions Of Nanopropolis In Various Diseases ...mentioning

confidence: 99%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Background and purpose: Scientific research is crucial to develop therapies for various disease severity levels, as modern drugs cause side effects and are difficult to predict. Researchers are exploring herbal alternatives with fewer side effects, particularly propolis, which has been validated through in vitro, in vivo, and clinical studies. This will focus on scientific evidence and its supporting technology for developing new bioactive compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of herbal medicines, which often have poor bioavailability due to their high molecular weight and solubility in water, particularly in oral medicines. This technology can enhance propolis's effects through multi-target therapy and reduce side effects. Experimental approach: All publications related to each section of this review were discovered using the search engines Google Scholar, Scopus, and Pubmed. This was only available for publication between 2013 and 2023. The selected publications were used as references in this review after being thoroughly studied. Key results: Evaluation of propolis active compounds, the classification of propolis nano formulations, design concepts, and mechanisms of action of propolis nano formulation. Additionally, the challenges and prospects for how these insights can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a list of nanoformulation propolis has been reported. This review concludes the difficulties encountered in developing large-scale nanoformulations. To commercialize them, improvements in nano carrier synthesis, standardized evaluation methodology within the framework of strategy process improvement, and Good Manufacturing Practices would be required.

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Section: Pharmacological Actions Of Nanopropolis In Various Diseases ...mentioning

confidence: 99%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

View full text Add to dashboard Cite

show abstract

“…Pharmaceutics 2021, 13, 2021 2 of 14 Despite the advantages of propolis, however, its low aqueous solubility is a major drawback for formulation development and functional research. Many studies have been conducted using poloxamers to improve the solubility of propolis [22][23][24]. Poloxamers are polypropylene oxide (PEO)-polyethylene oxide (PPO)-polypropylene oxide (PEO) triple block copolymers with the thermoreversible gelling property.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activities of Propolis in Poloxamer Based Topical Gels

Ban

Chung

et al. 2021

Pharmaceutics

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Propolis contains a group of compounds with various activities. However, their low solubility is a drawback for the development of pharmaceutical formulations. In this study, poloxamers as a solubilizer and gelling agent were evaluated to develop a topical antimicrobial formulation of propolis. The effects of poloxamer type and concentration on the propolis solubility, release rate, and antimicrobial activities were investigated. Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) were the representative bacteria and fungi, respectively. At 5%, poloxamer 407 (P407) and poloxamer 188 (P188) enhanced the propolis solubility by 2.86 and 2.06 folds, respectively; at 10%, they were 2.81 and 2.59 folds, respectively. The micelle size in the P188 formulation increased in the presence of propolis, whereas there was no change in the P407 formulation. Release rates of propolis decreased with the P188 concentration increase, which was attributed to viscosity increase. Both P188 and P407 formulations showed antimicrobial activity against S. aureus in a time-kill kinetics assay. However, only the P188 formulation reduced the cell’s numbers significantly against C. albicans, compared to the control. We speculate that P188 mixed micelles were more effective in releasing free active compounds to exhibit anti-microbial activity compared to the P407 micelles encapsulating the hydrophobic compounds in their cores. Propolis in P188 formulation is proposed as a potential topical antimicrobial agent based on its activity against both S. aureus and C. albicans.

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https://researchopenworld.com/effect-of-propolis-nanoparticles-on-early-stage-wound-healing-in-a-diabetic-noncontractile-wound-model/#

Cited by 2 publications

References 25 publications

New insights of propolis nanoformulation and its therapeutic potential in human diseases

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Antimicrobial Activities of Propolis in Poloxamer Based Topical Gels

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