HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells

Mazzio, Elizabeth; Soliman, Karam F.A.

doi:10.21873/cgp.20016

Cited by 15 publications

(8 citation statements)

References 48 publications

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“…The largely used corn, for example, in the form of corn oil induces a differential profile of the expression of tens of miRNAs related to carcinogenesis in the micro dissected liver of rats [136]. Moreover, the kaempferol, contained in grapes, green tea, and potatoes; the resveratrol of grapes, red wine, blueberries, and peanuts; the sinapinic acid in wine and vinegar; the diallyl disulfide of garlic; and the zerumbone of ginger have recently been considered as "natural HDAC inhibitors" [137] and show an in vitro anti-mitotic effect by regulating miRNAs involved in tumor suppression [138]. Hence, a further motivation to better study these dietary epigenetic regulators, some of them absent in MD, regarding their target specificity to gain potential anticancer dietary epi-adjuvants.…”

Section: American Foodsmentioning

confidence: 99%

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

et al. 2020

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The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the “Environment-Livings-Environment” relationship and an excellent patchwork of interconnected biological actions working toward human health.

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Section: American Foodsmentioning

confidence: 99%

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

et al. 2020

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“…However, Sannigrahi et al observed significantly decreased expression of hsa‐miR‐658 in an HPV‐positive HNC cohort and in TCGA tissue samples (Sannigrahi et al., 2018). Mazzio found that the overexpression of hsa‐miR‐23b‐5p could destroy some important oncogenes, including but not limited to NFkB , KRAS , MYC and AK2 (Mazzio & Soliman, 2017). Chang et al suggested that increased expression of mature hsa‐let‐7i‐5p could be predictive of improved breast cancer survival (Chang, Wang, Chapin, & Huang, 2016).…”

Section: Discussionmentioning

confidence: 99%

Preliminary investigation of the function of hsa_circ_0049356 in nonobstructive azoospermia patients

Liu

Wen

et al. 2020

Andrologia

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Nonobstructive azoospermia (NOA), which is considered the most severe form of male infertility, has placed a heavy burden on families and society. As vital regulators of transcriptional and post‐transcriptional levels, Noncoding RNAs (ncRNAs) are closely related to all the pathophysiological processes involved in infertility in males, especially spermatogenesis. Our study explored the expression levels of circ_0049356 in both the whole blood and seminal plasma samples of idiopathic NOA patients via quantitative real‐time PCR. Furthermore, the relative expression of its host gene (CARM1) was also determined using the same methods. In addition, as circRNAs have been demonstrated to regulate gene expression as miRNAs sponge, we predicted a total of five miRNAs and 101 mRNAs as putative downstream targets and constructed a circRNA‐miRNA‐mRNA network. Based on the predictions, Gene Ontology and KEGG pathway analyses were performed for further bioinformatics analysis to explore the potential function and investigate the circ_0049356‐miRNA‐mRNA interactions. Our results show target mRNAs that have been predicted to regulate guanyl‐nucleotide exchange factor activity to mediate the GTP/GDP exchange, and downstream targets possibly involved in the regulation of the actin cytoskeleton, which play a significant role in cytoskeleton rearrangement of germ cells during spermatogenesis.

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“…A complex comprised of miRNAs and a protein known as RISC (RNA induced silencing complex) bind to the target mRNA and degrade it, causing gene silencing (103). miRNAs play crucial roles in the development, apoptosis, cell differentiation and proliferation under normal conditions (104). There is experimental evidence to indicate that a considerable number of miRNAs can play oncogenic or tumour-suppressive roles (105).…”

Section: Epigenetic Modifications In Human Cancermentioning

confidence: 99%

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

et al. 2022

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Among the different types of mango species, Mangifera indica (MI) and Mangifera zeylanica (MZ) are well known for their therapeutic potential. MI is a pharmacologically and phytochemically diverse plant. Extracts prepared from different parts (bark, leaves, roots, seeds, flowers and fruits) of MI and major mango phytochemicals have been reported to exert a range of pharmacological effects. MZ is a plant endemic to Sri Lanka. The bark of MZ has been used in the Sri Lankan traditional medicine for the treatment of various ailments and conditions, including cancer. Recently, substantial efforts have been made to provide a scientific validation for its traditional use in the treatment of cancer. The present review article describes the pharmacological activities, including anti-inflammatory, antioxidant, anticancer, anti-microbial, anti-diabetic and anti-obesity properties of MI. Furthermore, the anticancer potential of MZ bark extracts and information on compounds isolated from MZ and their bio-activities are also described. The effects of major Mangifera compounds on epigenetic modifications have been widely studied. Therefore, the ability of Mangifera compounds to function as epigenetic drugs in the context of cancer drug discovery has become a promising area of investigation. However, an assessment of the clinical efficacy, and potential adverse and toxic effects of mango extracts is essential prior to their use in clinical practice.

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HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells

Abstract: Abstract. Background , with several miRNAs overlapping in the upward direction by both GSE and TSA (e.g. hsa-miR23b-5p, hsa-miR-27b-5p, hsa-miR-1180-3p, hsa-miR-6880-5p and hsa-mir-943

Cited by 15 publications

References 48 publications

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

Preliminary investigation of the function of hsa_circ_0049356 in nonobstructive azoospermia patients

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

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